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Epidemiology of the M-component immunoglobulin types of multiple myeloma

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The purpose of this population-based case-control study was to learn whether risk factors differ for the individual immunoglobulin types of multiple myeloma. In particular, we sought to determine whether IgA and IgG myeloma were related to a history of exposure to reported IgA- and IgG-stimulating conditions, respectively, or to a history of selected occupational and physicochemical exposures. The M-component immunoglobulin type was determined from immunoelectrophoresis as reported in medical records, and exposure status was obtained through in-person interviews. IgG (56 percent) and IgA (22 percent) M-components predominated. For 17 percent of cases, no peak was found on immunoelectrophoresis; they were presumed to have light-chain myeloma. Persons with these three types of myeloma did not differ with respect to distributions of age or race, but a somewhat higher proportion of light-chain cases were women (58 percent cf 45 percent of all other cases). Detailed analysis of the IgA and IgG subtypes provided little evidence that they differ with respect to prior immune stimulation or employment in several specific jobs. IgA myeloma, but not IgG myeloma, was associated modestly with a history of exposure to chest and dental X-rays. Our study provides little evidence that IgA and IgG myeloma differ with respect to the risk factors examined.

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References

  1. Merlini G, Farhangi M, Osserman EF. Monoclonal immunoglobulins with antibody activity in myeloma, macroglobulinemia and related plasma cell dyscrasias. Sem Oncol 1986; 13: 350–65.

    Google Scholar 

  2. Herrinton LJ, Weiss NS, Olshan AF. Multiple myeloma. In: Schottenfeld D, Fraumeni JF, eds. Cancer Epidemiology and Prevention, second edition. Philadelphia: WB Saunders Inc. (in press).

  3. Schafer AI, Miller JB. Association of IgA multiple myeloma with pre-existing disease. Br J Haematol 1979; 41: 19–24.

    Google Scholar 

  4. Koepsell TD, Daling JR, Weiss NS, et al. Antigenic stimulation and the occurrence of multiple myeloma. Am J Epidemiol 1987; 126: 1051–62.

    Google Scholar 

  5. Waterhouse J, Muir C, Shanmugaratnam K, Powell J, eds. Cancer Incidence in Five Continents. Lyon, France: International Agency for Research on Cancer, 1982: 148.

    Google Scholar 

  6. Morris PD, Koepsell TD, Daling JR, et al. Toxic substance exposure and multiple myeloma: a case-control study. JNCI 1986; 76: 987–94.

    Google Scholar 

  7. Williams AR, Weiss NS, Koepsell TD, Lyon JL, Swanson GM. Infectious and noninfectious exposures in the etiology of light chain myeloma: a case-control study. Cancer Res 1989; 49: 4038–41.

    Google Scholar 

  8. Oppenheim JJ, Shevach EM. Immunophysiology: the Role of Cells and Cytokines in Immunity and Inflammation. New York: Oxford University Press, 1990: 145.

    Google Scholar 

  9. Bergmann KC, Waldman RH. Stimulation of secretory antibody following oral administration of antigen. Rev Inf Dis 1988; 10: 939–50.

    Google Scholar 

  10. Koch HJ, Meyer J. Detection of antibodies to Neisseria gonarrhoeae in cervicovaginal secretion and in serum. Zeit Hautkrankheiten 1988; 15: 897–8, 905–6.

    Google Scholar 

  11. von Wulffen H, Grote HJ, Gatermann S, Löning T, Berger B, Buhl C. Immunoblot analysis of immune response to Campylobacter pylori and its clinical associations. J Clin Pathol 1988; 41: 653–9.

    Google Scholar 

  12. Crabtree JE, Taylor JD, Wyatt JI, et al. Mucosal IgA recognition of Helicobacter pylori 120 kDa protein, peptic ulceration, and gastric pathology, Lancet 1991; 338: 332–5.

    Google Scholar 

  13. Tanaka S, Suzuki T. Anti-Treponema pallidum IgM, IgA, and IgG subclass antibody responses after treatment in patients with syphilis at various stages: 1. Assessments by enzyme-linked immunosorbent assay. Genitourin Med 1990; 66: 171–7.

    Google Scholar 

  14. Ogra PL, Garofalo R. Secretory antibody reponse to viral vaccines. Prog Med Virol 1990; 37: 156–89.

    Google Scholar 

  15. Coyle PK, Sibony PA. Viral antibodies in normal tears. Invest Ophthalmol Visual Sci 1988; 29: 1552–8.

    Google Scholar 

  16. Yao QY, Rowe M, Morgan AJ, et al. Salivary and serum IgA antibodies to the Epstein-Barr virus glycoprotein gp340: Incidence and potential for virus neutralization. Int J Cancer 1991; 48: 45–50.

    Google Scholar 

  17. Friedman MG, Phillip M, Dagan R. Virus-specific IgA in serum, saliva, and tears of children with measles. Clin Exp Immunol 1989; 75: 58–63.

    Google Scholar 

  18. Staleton JT, Lange DK, LeDuc JW, Binn LN, Jansen RW, Lemon SM. The role of secretory immunity in hepatitis A virus infection. J Inf Dis 1991; 163: 7–11.

    Google Scholar 

  19. Michaelides S, Grange JM. Relationship between immunoglobulin levels, tuberculin hypersensitivity and radiological extent of disease in Greek patients with pulmonary tuberculosis. Eur Respir J 1989; 2: 727–30.

    Google Scholar 

  20. van de Graaf EA, Out TA, Kobesen A, Jansen HM. Lactoferrin and secretory IgA in the bronchoalveolar lavage fluid from patients with a stable asthma. Lung 1991; 169: 275–83.

    Google Scholar 

  21. Noda Y, Yasuoka S, Tani K, Ogura T, Ogawara M, Kitatani F. Secretory IgA(S-IgA) levels in sera from patients with difuse panbronchiolitis. Jap J Med 1989; 28: 189–95.

    Google Scholar 

  22. Trinchieri A, Braceschi L, Tiranti D, Dell'Acqua S, Mandressi A, Pisani E. Secretory immunoglobulin A and inhibitory activity of bacterial adherence to epithelial cells in urine from patients with urinary tract infections. Urolog Res 1990; 18: 305–8.

    Google Scholar 

  23. Hansen PGC, Hennessy EJ, Blake H, et al. Appearance of IgG and IgA antibodies in human bile after tetanus toxoid immunization. Clin Exp Immunol 1989; 77: 215–20.

    Google Scholar 

  24. Vuitton DA, Seills E, Cozon G, Rossel M, Bresson-Hadni S, Revillard JI. Secretory immunoglobulin A in hepatobiliary diseases. Dig Dis 1991; 9: 78–91.

    Google Scholar 

  25. Østerballe O, Lwenstein H, Norn S, et al. Immunotherapy with grass pollen major allergens. Immunological results from a prospective 3-year double blind study. Allergy 1982; 37: 491–501.

    Google Scholar 

  26. Shimizu K, Kitoh S. Increase in the number of lymphocytes secreting IgG following blood transfusion. Blood 1982; 59: 312–6.

    Google Scholar 

  27. Goldblum RM, Pelley RP, O'Donell AA, Pyron D, Heggers JP. Antibodies to silicone elastomers and reactions to ventriculoperitoneal shunts. Lancet 1992; 340: 510–13.

    Google Scholar 

  28. Ameno S, Ameno K, Fuke C, Kiryu T, Ijiri I. IgG subclass distributions of anti-horse serum antibodies and natural venom-antibodies produced in response to antivenom injection or snake bite in humans. Toxicon 1990; 28: 347–50.

    Google Scholar 

  29. Vandeligt KR, Ross SA, Matheson DS. Immunologic studies of patients with diabetes mellitus who have received long term insulin therapy: Lymphocyte reactivity to insulin is correlated with impaired immunoglobulin secretion in vitro. Clin Immunol Immunopathol 1989; 53: 422–9.

    Google Scholar 

  30. Yio XY, Jin B, Yin FZ, Li XJ. Bile secretory immunoglobulin A in biliary infection and cholelithiasis. Gastroenterol 1992; 102: 1000–8.

    Google Scholar 

  31. Klemp P, Cooper RC, Strauss FJ, Jordaan ER, Przybojewski JZ, Nel N. Anticardiolipin antibodies in ischaemic heart disease. Clin Exp Immunol 1988; 74: 254–7.

    Google Scholar 

  32. Jacob E, Durham LC, Falk MC, Williams TJ, Wheat LJ. Antibody response to teichoic acid and peptidoglycan in Staphylococcus aureaus osteomyelitis. J Clin Microbiol 1987; 25: 122–7.

    Google Scholar 

  33. Bielory L, Kemeny DM, Richards D, Lessof MH. IgG subclass antibody production in human serum sickness. J Allergy Clin Immunol 1990; 85: 573–7.

    Google Scholar 

  34. Kemeny DM, Lessof MH. Immune response to bee venom. II. Quantitation of the absolute amounts of IgE and IgG antibodies by saturation analysis. Int Arch Allergy App Immunol 1987; 83: 113–20.

    Google Scholar 

  35. Harper DR, Grose C. IgM and IgG responses to varicella-zoster virus p32/p36 complex after chickenpox and zoster, congenital and subclinical infections, and vaccination. J Infect Dis 1989; 159: 444–51.

    Google Scholar 

  36. Paroczai C, Nemeth-Csoka M. Estimation of serum anticollagen and the antibodies against chondrocyte membrane fraction: Their clinical diagnostic significiance in osteoarthritis. Clin Biochem 1988, 21: 117–21.

    Google Scholar 

  37. Entwistle CC. Antibody to vaccinia. I. Detection by immunoelectroendosmophoresis. Vox Sanguinis 1974; 27: 459–63.

    Google Scholar 

  38. Turneer M, Van Vooren JP, Nyabenda J, et al. The humoral immune response after BCG vaccination in humans: consequences for the serodiagnosis of tuberculosis. Eur Respir J 1988; 1: 589–93.

    Google Scholar 

  39. Tsuji M, McMahon G, Reen D, Puri P. New insights into the pathogenesis of appendicitis based on immunocytochemical analysis of early immune response. J Pediatr Surg 1990; 25: 449–52.

    Google Scholar 

  40. Taylor B, Fergusson DM, Mahoney GN, Hartley WA, Abbott J. Specific IgA and IgE in childhood asthma, eczema and food allergy. Clin Allergy 1982; 12: 499–505.

    Google Scholar 

  41. Demers PA, Vaughan TL, Koepsell TD, et al. A case-control study of multiple myeloma and occupation. Am J Ind Med (in press).

  42. Kleinbaum DG, Kupper LL, Morganstern H. Epidemiologic Research: Principles and Quantitative Methods. Belmont, CA: Lifetime Learning Publications, 1982.

    Google Scholar 

  43. Wisløff F, Andersen P, Andersson TR, et al. Has the incidence of multiple myeloma in old age been underestimated. The myeloma project of health region I in Norway. I. Eur J Haematol 1991; 47: 333–7.

    Google Scholar 

  44. Wisløff F, Andersen P, Andersson TR, et al. Incidence and follow-up of asymptomatic multiple myeloma. The myeloma project of health region I in Norway. II. Eur J Haematol 1991; 47: 338–41.

    Google Scholar 

  45. Jancelewicz Z, Takatsuki K, Sugai S, Pruzanski W. IgD multiple myeloma: review of 133 cases. Arch Intern Med 1975; 135: 87–93.

    Google Scholar 

  46. Osserman EF, Merlini G, Butler VP. Multiple myeloma and related plasma cell dyscrasias. JAMA 1987; 258: 2930–7.

    Google Scholar 

  47. Ichimaru M, Ishimaru T, Mikami M, Matsunaga M. Multiple myeloma among atomic bomb survivors in Hiroshima and Nagasaki, 1950–76; relationship to radiation dose absorbed by marrow. JNCI 1982; 69: 323–8.

    Google Scholar 

  48. Radl JR, Liu M, Hoogeveen CM, et al. Monoclonal gammapathies (sic) in long-term surviving Rhesus monkeys after lethal irradiation and bone marrow transplantation. Clin Immunol Immunopathol 1991; 60: 305–9.

    Google Scholar 

  49. Eriksson M, Karlsson M. Occupational and other environmental factors and multiple myeloma: a population based case-control study. Br J Ind Med 1992; 49: 95–103.

    Google Scholar 

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Authors
  1. Lisa J. Herrinton
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  2. Paul A. Demers
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  3. Thomas D. Koepsell
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  4. Noel S. Weiss
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  5. Janet R. Daling
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  6. John W. Taylor
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  7. Joseph L. Lyon
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  8. G. Marie Swanson
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  9. Raymond S. Greenberg
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Additional information

Ms Herrinton and Drs Koepsell, Weiss, and Daling are with the Department of Epidemiology, University of Washington, Seattle, WA, USA, and the Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. Dr Demers is with the Department of Environmental Health, University of Washington, Seattle, WA, USA. Dr Taylor is with Group Health Cooperative of Puget Sound, Seattle, WA, USA. Dr Lyon is with the School of Medicine, University of Utah, Salt Lake City, UT, USA. Dr Swanson is with the Cancer Center, Michigan State University, East Lansing, MI, USA. Dr Greenberg is with the School of Public Health, Emory University, Atlanta, GA, USA. Address correspondence to Ms Lisa Herrinton, Fred Hutchinson Cancer Research Center, 1124 Columbia MP-381, Seattle, WA 98104, USA. The project was supported by grants CA23350, CA39779, and CA09168 from the US National Cancer Institute.

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Herrinton, L.J., Demers, P.A., Koepsell, T.D. et al. Epidemiology of the M-component immunoglobulin types of multiple myeloma. Cancer Causes Control 4, 83–92 (1993). https://doi.org/10.1007/BF00053148

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  • DOI: https://doi.org/10.1007/BF00053148

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