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Cytogenetic abnormalities in cancer: with special emphasis on tumor heterogeneity

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Abstract

There is a considerable amount of cytogenetic data available to support the statements that (1) cancer is a genetic disease; (2) most cancers are monoclonal in origin; (3) tumor cells are more genetically unstable than normal cells; (4) the genetic instability may be inherited, acquired, or both during the lifespan of the individual tumor; (5) tumor metastasis is a nonrandom, controlled process, and clonal in origin; (6) malignant tumors are genetically heterogeneous and contain multiple subpopulations that may differ in their biological properties; (7) some tumors might be difficult to treat successfully because of their resistant nature; and (8) tumor cells may acquire resistance because of gene amplification. For these reasons it is extremely important to study the biology of malignant tumor cells in order to determine their effective treatments and control this dreadful disease.

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References

  1. Foulds L: The experimental study of tumor progression: A review. Cancer Res 14: 327–338, 1954

    Google Scholar 

  2. Foulds L: The natural history of cancer. J Chronic Dis 8: 2–37, 1958

    Google Scholar 

  3. Nowell PC: Chromosomes changes and the clonal evolution of cancer. In: German J (ed) Chromosome and Cancer. John Wiley & Sons, Inc., New York, 1974, pp 267–285

    Google Scholar 

  4. Nowell PC: The clonal evolution of tumor cell populations. Acquired genetic lability permits stepwise selection of variant sublines and underlies tumor progression. Science 194: 23–28, 1976

    Google Scholar 

  5. Nowell PC: Mechanisms of tumor progression. Cancer Res 46: 2203–2207, 1986

    Google Scholar 

  6. Klein G, Klein E: Evolution of tumors and the impact of molecular oncology. Nature 315: 190–195, 1985

    Google Scholar 

  7. Fidler IJ, Gersten DM, Hart IR: The biology of cancer invasion and metastasis. Adv Cancer Res 28: 149–250, 1978

    Google Scholar 

  8. Poste G, Fidler IJ: The pathogenesis of cancer metastasis. Nature 283: 139–146, 1980

    Google Scholar 

  9. Killion JJ, Fidler IJ: The biology of tumor metastasis. Seminar Oncol 16: 106–115, 1989

    Google Scholar 

  10. Makino S: The chromosome cytology of the ascites tumors of the rat, with special reference to the concept of the stemline cell. Int Rev Cytol 6: 25–84, 1957

    Google Scholar 

  11. Cifone M, Fidler IJ: Increasing metastatic potential is associated with increasing instability of clones isolated from murine neoplasms. Proc Natl Acad Sci 78: 6949–6952, 1981

    Google Scholar 

  12. Ling V, Chambers AF, Harris JF, Hill RP: Dynamic hetcrogeneity and metastasis. J Cellular Physiol suppl 3: 99–103, 1984

    Google Scholar 

  13. Weinberg RA: Oncogenes, antioncogenes, and the molecular bases of multistep carcinogenesis. Cancer Res 49: 3713–3721, 1989

    Google Scholar 

  14. Nowell PC, Hungerford DA: A minute chromosome in human chronic granulocytic leukemia. Science 132: 1497, 1960

    Google Scholar 

  15. Rowley JD: A new consistent chromosomal abnormality in chronic myelogenous leukemia identified by quinacrine fluorescence and Giemsa staining. Nature 243: 290–293, 1973a

    Google Scholar 

  16. Sandberg AA: The Chromosomes in Human Cancer and Leukemia. Elsevier North Holland, New York, 1980

    Google Scholar 

  17. Zech L, Haglund U, Nilsson K, Klein G: Characteristic chromosomal abnormalities in biopsies and lymphoid-cell lines from patients with Burkitt and non-Burkitt lymphomas. Int J Cancer 17: 47–56, 1976

    Google Scholar 

  18. Pathak S: Chromosome constitution of human solid tumors. Cancer Bull 35: 126–131, 1983

    Google Scholar 

  19. Trujillo JM, Cork A, Ahearn MJ, Youness EL, McCredie KB: Hematologic and cytoloci characterization of 8/21 translocation acute granulocytic leukemia. Bloo 53: 695–706, 1978

    Google Scholar 

  20. Autio K, Turunen O, Penttila O, Eramao E, de la Chapelle A, Schroder J: Human chronic lymphocytic leukemia: Karyotypes in different lymphocyte populations. Cancer Genet Cytogenet 1: 147–155, 1979

    Google Scholar 

  21. Sandberg AA: Chromosomal changes in the lymphomas. Hum Pathol 12: 531–540, 1981

    Google Scholar 

  22. Bloomfield CD, Peterson LC, Yunis JJ, Brunning RD: The Philadelphia chromosome (Ph1) in adults presenting with acute leukemia: A comparison of Ph1+ and Ph1-patients. Br J Haematol 36: 347–358, 1977

    Google Scholar 

  23. Rowley RD: Identification of a translocation with quinacrine fluorescence in a patient with acute leukemia. Ann Genet (Paris) 16: 109–112, 1973b

    Google Scholar 

  24. Mecucci C, van Orphoven A, Tricot G, Michaux JL, Delannoy A, van den Berghe H: Trisomy 4 identifies a subset of acute nonlymphocytic leukemias. Blood 67: 1328–1332, 1986

    Google Scholar 

  25. Rowley RD, Golomb HM, Vardiman J, Fukuhara S, Dougherty C, Potter D: Further evidence for a nonrandom chromosomal abnormality in acute promyelocytic leukemia. Int J Cancer 20: 869–872, 1977

    Google Scholar 

  26. Yunis JJ: The chromosomal basis of human neoplasia. Science 221: 227–236, 1983

    Google Scholar 

  27. Hagemeizer A, Hahlen K, Sizoo W, Abels J: Translocation (9; 11)(q21; q23) in three cases of acute monoblastic leukemia. Cancer Genet Cytogenet 5: 95–105, 1982

    Google Scholar 

  28. Bloomfield CD, Lindquist LL, Brunning RD, Yunis JJ, Coccia PF: The Philadelphia chromosome in acute leukemia. Virchows Arch 29: 81–91, 1978

    Google Scholar 

  29. Van den Berghe H, David G, Orshowven AB, Louwagie A, Verwilghen R, Casteels-Van Daele M, Eggermont E, Eckels R: A new chromosome anomaly in acute lymphoblastic leukemia. Hum Genet 46: 173–180, 1979

    Google Scholar 

  30. Berger R, Bernheim A, Brouet JC, Daniel MT, Flandrin G: t(8;14) translocation in a Burkitt's type of lymphoblastic leukemia (L3). Br J Haematol 43: 87–90, 1979a

    Google Scholar 

  31. Miyoshi I, Hiraki S, Kimura K, Miyomoto K, Sato J: 2/8 translocation in a Japanese Burkitt's lymphoma. Experientia 35: 742–743, 1979

    Google Scholar 

  32. Berger R, Bernheim A, Weh H-J, Flandrin G, Daniel MT, Brouet J-C, Colbert N: A new translocation in Burkitt's tumor cells. Human Genet 53: 111–112, 1979b

    Google Scholar 

  33. Limon J, Turc-Carel C, Dalcin P, Rao U, Sandberg AA: Recurrent chromosome translocations in liposarcoma. Cancer Genet Cytogenet 22: 93–94, 1986

    Google Scholar 

  34. Turc-Carel C, Lizard-Nacol S, Justrabo E, Favot M, Philip T, Tabone E: Consistent chromosomal translocation in alveolar rhabdomyosarcoma. Cancer Genet Cytogenet 19: 361–362, 1986a

    Google Scholar 

  35. Aurias A, Rimbaut C, Buffe D, Zucker JM, Mazabraud A: Translocation involving chromosome 22 in Ewings' sarcoma. A cytogenetic study of four fresh tumors. Cancer Genet Cytogenet 12: 21–25, 1984

    Google Scholar 

  36. Turc-Carel C, Dalcin P, Limon J, Li F, Sandberg AA: Translocation x:18 in synovial sarcoma. Cancer Genet Cytogenet 22: 93–94, 1986b

    Google Scholar 

  37. Bell CW, Pathak S, Grant G, Frost P: A familial translocation involving chromosomes 3 and 21: Clinical findings and implications. Cytogenet Cell Genet 50: 59–60, 1989

    Google Scholar 

  38. Pathak S, Dhaliwal MK: Cytogenetic analysis of a leiomyosarcoma cell line SK-UT-JB: Normal diploid or with 21q deletion? Cancer Genet Cytogenet 41: 145–147, 1989

    Google Scholar 

  39. Wilson MG, Towner JW, Fujimoto A: Retinoblastoma and D-chromosome deletion. Am J Hum Genet 25: 57–61, 1973

    Google Scholar 

  40. Riccardi VM, Sujansky E, Smith AC, Francke U: Chromosomal imbalance in the aniridia Wilms' tumor association: 11p interstitial deletion. Pediatrics 61: 604–610, 1978

    Google Scholar 

  41. Cohen AJ, Li FP, Berg S, Marchetto DJ, Tsai S, Jacobs SE, Brown RS: Hereditary renal-cell carcinoma associated with a chromosomal translocation. New Engl J Med 301: 592–595, 1979

    Google Scholar 

  42. Pathak S, Strong LC, Ferrell RE, Trindade A: Familial renal cell carcinoma with a 3;11 chromosome translocation limited to tumor cells. Science 217: 939–941, 1982

    Google Scholar 

  43. Brodeur GM, Green AA, Hayes FA, Williams KJ, Williams DL, Tsiatis AA: Cytogenetic features of human neuroblastomas and cell lines. Cancer Res 41: 4678–4686, 1981

    Google Scholar 

  44. Whang-Peng J, Kao-Shan CS, Lee EC, Bunn PA, Carney DN, Gazdar AF, Minna JD: Specific chromosome defect associated with human small-cell lung cancer: deletion 3p (14–23). Science 215: 181–182, 1982

    Google Scholar 

  45. Pathak S, Siciliano MJ, Caillcau R, Wiseman CL, Hsu TC: A human breast adenocarcinoma with chromosome and isoenzyme markers similar to those of the HeLa line. JNCI 62: 263–271, 1979

    Google Scholar 

  46. Zankl H, Zang KD: Cytological and cytogenetical studies on brain tumors. IV. Identification of the missing G chromosome in human meningiomas as No. 22 by fluorescence technique. Humangenetik 14: 167–169, 1972

    Google Scholar 

  47. Bolger GB, Stanberg J, Kirsch IR, Hollis GF, Schwarz DF, Thomas GH: Chromosome translocation t(14,22) and oncogene (c-sis) variant in a pedigree with familial meningioma. New Engl J Med 312: 564–567, 1985

    Google Scholar 

  48. Pathak S, Drwing HL, Hsu TC: Involvement of chromosome 6 in rearrangements in human malignant melanoma cell lines. Cytogenet Cell Genet 36: 573–579, 1983

    Google Scholar 

  49. Trent JM, Rosenfeld SB, Meyskens FL: Chromosome 6q involvement in human malignant melanoma. Cancer Genet Cytogenet 9: 177–180, 1983

    Google Scholar 

  50. Becher R, Gibas Z, Sandberg AA: Chromosome 6 in malignant melanoma. Cancer Genet Cytogenet 9: 173–175, 1983

    Google Scholar 

  51. Wake N, Hreshchyshyn MM, Piver SM, Matsui S, Sandberg AA: Specific cytogenetic changes in ovarian cancer involving chromosome 6 and 14. Cancer Res 40: 4512–4518, 1980

    Google Scholar 

  52. Herrera L, Kakati S, Gibas L, Pictrzak E, Sandberg AA: Gardner syndrome in a man with an interstitial deletion of 5q. Am J Med Genet 25: 473–476, 1986

    Google Scholar 

  53. Dhaliwal MK, Pathak S, Winn RJ: Involvement of chromosome 12 in colorectal carcinoma: Evidence for specific deletion of 12p12. 39th M.D. Anderson Symposium on Fundamental Cancer Research, ‘Critical Molecular Determinants in Carcinogenesis’, September 16–19, 1986

  54. Pathak S, Kakati S: Cytogenetics of colorectal cancer. In: Augenlicht L (ed) Cell and Molecular Biology of Human Colon Cancer. CRC Press, Inc. Florida, 1989, pp 139–163

    Google Scholar 

  55. Atkin NB, Baker MC: Chromosome study of five cases of the prostate. Hum Genet 70: 359–364, 1985

    Google Scholar 

  56. Atkin NB, Baker MC: A specific chromosomal marker in seminoma and malignant teratoma of the testis? Cancer Genet Cytogenet 10: 199–204, 1983

    Google Scholar 

  57. Konopka JB, Watanabe SM, Witte ON: An alteration of the human c-abl/protein in K562 leukemia cells unmasks associated tyrosine kinase activity. Cell 37: 1035–1042, 1984

    Google Scholar 

  58. Nishikura K, Ar-Rushdi A, Erikson J, Watt R, Rovera G, Croce CM: Differential expression of the normal and of the translocated human c-myc oncogenes in B cells. Proc Natl Acad USA Sci 80: 4822–4826, 1983

    Google Scholar 

  59. Tsujimoto Y, Yunis J, Onorato-Showe L, Erikson J, Nowell PC, Crocc CM: Molecular cloning of the chromosomal breakpoint of B-cell lymphomas and leukemias with the t(11;14) chromosome translocation. Science 224: 1403–1406, 1984

    Google Scholar 

  60. Tsujimoto Y, Yunis J, Nowell PC, Croce CM: Cloning of the chromosome breakpoint of neoplastic B cells with the t(14; 18) chromosome translocation. Science 226: 1097–1099, 1984

    Google Scholar 

  61. Tsujimoto Y, Croce CM: Analysis of the structure, transcripts, and protein products of bcl-2, the gene involved in human follicular lymphoma. Proc Natl Acad Sci USA 83: 5214–5218, 1986

    Google Scholar 

  62. Huang HJ, Yee JK, Shew JY, Chen PL, Bookstein R, Friedman T, Lee YHL, Lee WH: Suppression of the neoplastic phenotype by replacement of the Rb gene in human cancer cells. Science 242: 1563–1566, 1988

    Google Scholar 

  63. Green AR: Recessive mechanisms of malignancy. Br J Cancer 58: 115–121, 1988

    Google Scholar 

  64. Knudson AG: Mutation and cancer: statistical study of retinoblastoma. Proc Natl Acad Sci USA 68: 820–823, 1971

    Google Scholar 

  65. Nowell PC: Genetic instability in cancer cells: Relationship to tumor cell heterogeneity. In: Tumor Cell Heterogeneity. Academic Press, Inc. 1982, pp 351–365

  66. Mitelman F: The chromosomes of fifty primary Rous rat sarcomas. Hereditas 69: 155–186, 1971

    Google Scholar 

  67. Rowley JD: Ph1 positive leukemia, including chronic myelogenous leukemia. Clin Haematol 9: 55–86, 1980

    Google Scholar 

  68. Wolman SR: Karyotypic progression in human tumors. Cancer Metastasis Reviews 2: 257–293, 1983

    Google Scholar 

  69. Heim S, Mandahl N, Mitelman F: Genetic convergence and divergence in tumor progression. Cancer Res 48: 5911–5916, 1988

    Google Scholar 

  70. Cabanillas F, Pathak S, Trujillo J, Manning J, McLaughlin P, Velasquez WS, Hagemeister FB, Goodacre A, Cork A, Butler JJ: Frequent non-random abnormalities of chromosomes 14q32, 18q21 and 17p11–12 in 27 consecutive previously untreated patients with large cell lymphoma. Cancer Res 48: 5557–5564, 1988

    Google Scholar 

  71. Pathak S, Goodacre A: Specific chromosome anomalies and predisposition to human breast, renal cell, and colorectal carcinoma. Cancer Genet Cytogenet 19: 29–36, 1986

    Google Scholar 

  72. Muleris M, Salmon RJ, Dutrillaux B: Chromosomal study demonstrating the clonal evolution and metastatic origin of a metachronous colorectal carcinoma. Int J Cancer 38: 167–172, 1986

    Google Scholar 

  73. German J: Genes which increase chromosome instability in somatic cells and predispose to cancer. Prog Med Genet 8: 61–101, 1972

    Google Scholar 

  74. German J: Chromosome-breakage syndromes; different genes, different treatments, different cancers. In: Generoso WM, Shelby MD, de Serress FJ (ed) DNA Repair and Mutagenesis in Eukaryotes. Plenum Press, New York, 1980, pp 429–439

    Google Scholar 

  75. Hecht F, McCaw BK: Chromosome instability syndrome. Prog in Cancer Res Ther 3 (Genetics of Human Cancer): 105–123, 1977

  76. Setlow RB: Repair deficient human disorders and cancer. Nature 271: 713–717, 1978

    Google Scholar 

  77. Cleaver JE: Defective repair replication of DNA in xeroderma pigmentosum. Nature 218: 652–656, 1968

    Google Scholar 

  78. Maher VM, Ouellette LM, Curren RD, McCormik JJ: Frequency of ultraviolet light induced mutation is higher in xeroderma pigmentosum variant cells. Nature 261: 593–595, 1976

    Google Scholar 

  79. Paterson MC, Smith PJ: Ataxia telangiectasia: an inherited human disorder involving hypersensitivity to ionizing radiation and related DNA-damaging chemicals. Ann Rev Genet 13: 291–318, 1979

    Google Scholar 

  80. Hsu TC, Pathak S, Samaan N, Hickey RC: Chromosome instability in patients with medullary carcinoma of the thyroid. J Am Med Assoc 246: 2046–2048, 1981

    Google Scholar 

  81. Pathak S, Hsu TC, Samaan N, Hickey RC, Giesler CF: Chromosome instability in humans: A heritable trait? Braz J Genet 3: 577–586, 1982b

    Google Scholar 

  82. Samaan NA, Hsu TC, Pathak S, Saad MF, Ordonez NG, Hickey RC: Chromosomal instability in medullary carcinoma of the thyroid. World J Surg 8: 487–492, 1984

    Google Scholar 

  83. Delhanty JDA, Davis MB, Wood J: Chromosome instability in lymphocytes, fibroblasts, and colon epithelial-like cells from patients with familial polyposis coli. Cancer Genet Cytogenet 8: 27–50, 1983

    Google Scholar 

  84. Hsu TC: Genetic susceptibility to carcinogenesis. Cancer Bull 38: 125–128, 1986

    Google Scholar 

  85. Emerit I, Michelson AM, Levy A, Camus JP, Emerit J: Chromosome-breaking agent of low molecular weight in human systemic lupus erythematosus protector effect of superoxide dismutase. Hum Genet 55: 341–344, 1980

    Google Scholar 

  86. Pathak S, Hsu TC, Samaan N, Hickey RC: Cytogenetic abnormalities in a patient with hypercalcemia and papillary thyroid carcinoma. Hum Genet 60: 291–293, 1982b

    Google Scholar 

  87. Pathak S, Dhaliwal MK, Hopwood VL: Genetic susceptibility, somatic mosaicisms, and predisposition to human cancer. Anticancer Res 9: 17–20, 1989

    Google Scholar 

  88. Seabright M: Patterns of induced abcrrations in humans with abnormal complements. Chromosomes Today 5: 293–297, 1976

    Google Scholar 

  89. McClintock B: Controlling elements and the gene. Cold Spring Harbor Symp Quant Biol 21: 197–216, 1956

    Google Scholar 

  90. Pathak S: Chromosome alterations in speciation and neoplastic transformation: A parallelism. In: Sharma T (ed) Advances in Chromosomes Research. Springer-Verlag, Narosa Publishing House, New Delhi (in press), 1989

    Google Scholar 

  91. Wurster-Hill DH, Gray CW: Giemsa banding patterns in the chromosomes of twelve species of cats (Felidae). Cytogenet Cell Genet 12: 377–397, 1973

    Google Scholar 

  92. Heppaer G: Tumor cell societies. J Natl Cancer Inst 81: 648–649, 1989

    Google Scholar 

  93. Pathak S, Wang Z, Dhaliwal MK, Sacks PC: Telomeric association: Another characteristic of cancer chromosomes? Cytogenet Cell Genet 47: 227–229, 1988

    Google Scholar 

  94. Cairns J: Mutation selection and the natural history of caneer. Nature 255: 197–200, 1975

    Google Scholar 

  95. Hesten L: Alzhemer's disease, trisomy 21, and mycloproliterative disorders: Associations suggesting a genetic diathesis. Science 196: 322–323, 1977

    Google Scholar 

  96. Chan JYH, Becker FF: Decreased fidelity of DNA polymcrase activity during N-2-fluorenylacetamide hepatocarcinogenesis. Proc Natl Acad Sci USA 76 814–818, 1979

    Google Scholar 

  97. Mukerjee D, Bowen J, Anderson DE: Simian papovavirus 40 transformation of cells from a cancer patient with XY/XXY mosaic Klinefelter's syndrome. Cancer Res 30: 1769–1772, 1970

    Google Scholar 

  98. Hogstedt B, Mitelman FP: The interrelations of micronuclei, chromosomal instability, and mutational activity in acute non-lymphocytic leukemia-A hypothesis. Hereditas 95: 165–167, 1981

    Google Scholar 

  99. Pathak S: Constitutional translocations and predisposition to T- and B-cell malignancies. Cytogenet Cell Genet 43: 223–225, 1986

    Google Scholar 

  100. Cavenee WK, Dryja TP, Phillips RA, Benedict WF, Godbout R, Gillie BL, Murphree AL, Strong LC, White RL: Expression of recessive alleles by chromosomal mechanisms in retinoblastoma. Nature 305: 779–784, 1983

    Google Scholar 

  101. Sager R: Genetic suppression of tumor formation: A new frontier in cancer research. Cancer Res 46: 1573–1580, 1986

    Google Scholar 

  102. Vogelstein B, Fearson ER, Kern SE, Hamilton SR, Preisinger AC, Nakamura Y, White R: Allclotype of colorectal carcinomas. Science 244: 207–211, 1989

    Google Scholar 

  103. Hsu TC, Zenzes MT: Mammaliar, chromosomes in vitro. XVII. Idiogram of the Chinese hamster. J Natl Cancer Inst 32: 857–869, 1964

    Google Scholar 

  104. Kato H, Yosida TH: Isolation of aneusomic clones from Chinese hamster cell line following induction of nondisjunction. Cytogenetics 10: 393–403, 1971

    Google Scholar 

  105. Stark GR, Wahl GM: Gene amplification. Ann Rev Biochem 53: 447–491, 1984

    Google Scholar 

  106. Wahl GM: The importance of circular DNA in mammalian gene amplification. Cancer Res 49: 1333–1340, 1989

    Google Scholar 

  107. Balaban-Malenbaum G, Gilbert F: Double minute chromosomes and the homogeneously staining regions in chromosomes of a human neuroblastoma cell line. Science 198: 739–741, 1977

    Google Scholar 

  108. Barker PE, Hsu TC: Are double minutes chromosomes? Exp Cell Res 113: 456–458, 1978

    Google Scholar 

  109. Giovanella BC, Stehlin JSJr. Williams LJ, Lee SS, Shepard RC: Heterotransplantation of human cancers into nude mice. Cancer 42: 2269–2281, 1978

    Google Scholar 

  110. Fidler IJ: Rationale and methods for the use of nude mice to study the biology and therapy of human cancer metastasis. Cancer Metastasis Rev 5: 29–49, 1986

    Google Scholar 

  111. Goldenberg DM, Pavia RA: Malignant potential of murine stromal cells after transplantation of human tumors indo nude mice. Science 212: 65–67, 1981

    Google Scholar 

  112. Beattie GM, Knowles AF, Jensen FC, Baird SM, Kaplan NO: Induction of sarcomas in athymic mice. Proc Natl Acad Sci USA 79: 3033–3036, 1982

    Google Scholar 

  113. Bowen JM, Cailleau R, Giovanella BC, Pathak S, Siciliano MJ: A retrovirus-producing transformed mouse cell line derived from a human breast adenocarcinoma transplanted in a nude mouse. In Vitro 19: 635–641, 1983

    Google Scholar 

  114. Heppner GH: Role of inflammatory cells in tumor progression and diversification. Tumor Progression and Metastasis 78: 151–155, 1988. UCLA Symposium on Molecular and Cellular Biology, GL Nicolson and IJ Fidler (eds), Alan R Liss Inc. N.Y.

    Google Scholar 

  115. Nathan CF, Brukner LH, Silverstein SC, Cohn ZA: Extracellular cytolysis by activated macrophages and granulocytes I. Pharmacological triggering of effector cells and the release of hydrogen peroxide. J Exp Med 149: 84–99, 1979

    Google Scholar 

  116. Cerutti PA: Prooxidant states and tumor promotion. Science 227: 375–381, 1985

    Google Scholar 

  117. Isaacs JT, Wake N, Coffey DS, Sandberg AA: Genetic instability coupled to clonal selection as a mechanism for tumor progression in the Dunning R-3327 rat prostate adenocarcinoma system. Cancer Res 42: 2353–2361, 1982

    Google Scholar 

  118. Elmore E, Kakunaga T, Barrett JC: Comparison of spontaneous mutation rates of normal and chemically transformed human skin fibroblasts. Cancer Res 43: 1650–1655, 1983

    Google Scholar 

  119. Frost F, Kerbel RS: On a possible epigenetic mechanism(s) of tumor cell heterogeneity: The role of DNA methylation. Cancer Metastasis Rev 2: 375–378, 1983

    Google Scholar 

  120. Holliday R: A new theory of carcinogenesis. Br J Cancer 40: 513–522, 1979

    Google Scholar 

  121. Heppner GH: Tumor heterogeneity. Cancer Res 44: 2259–2265, 1984

    Google Scholar 

  122. Nichols WW: Viral interactions with the mammalian genome relevant to neoplasia. In: German J (ed), Chromosome Mutation and Neoplasia. Alan R Liss, Inc., New York, 1983, pp 317–332

    Google Scholar 

  123. Fisher MS, Cifone MA: Enhanced metastatic potential of murine fibrosarcoma treated in vitro with ultraviolet radiation. Cancer Res 41: 3018–3023, 1981

    Google Scholar 

  124. Frost P, Kerbel RS, Hunt B, Man S, Pathak S: Selection of metastatic variants with identifiable karyotypic changes from a monmetastatic murine tumor after treatment with 2-deoxy-5-azacytidine or hydroxurea: Implications for the mechanisms of tumor progression. Cancer Res 47: 2690–2695, 1987

    Google Scholar 

  125. Magnus EM: Folate activity in serum and red cells of patients with cancer. Cancer Res 27: 490–497, 1967

    Google Scholar 

  126. Somayaji BN, Nelson RS, McGregor RF: Small intestinal function in malignant neoplasia. Cancer 29: 1215–1222, 1972

    Google Scholar 

  127. Branda RF, McCormack JJ, Perlmutter CA, Mathews LA, Robison SH: Effects of folate deficiency on the metastatic potential of murine melanoma cells. Cancer Res 48: 4529–4534, 1988

    Google Scholar 

  128. Menzies RC, Crossen PE, Fitzgerald PH, Gunz RW: Cytogenetic and cytochemical studies on marrow cells in B12 and folate deficiency. Blood 28: 581–594, 1966

    Google Scholar 

  129. Heath CW: Cytogenctic observations in vitamin B12 and folate deficiency. Blood 27: 800–815, 1966

    Google Scholar 

  130. Sutherland GR, Hecht F: Fragile sites on human chromosomes. Oxford Monographs on Medical Genetics No. 13, Oxford University Press, New York, 1985

    Google Scholar 

  131. Le Beau MM: Chromosomal fragile sites and cancer specific rearrangements. Blood 67: 849–858, 1986

    Google Scholar 

  132. Yunis JJ: Chromosomal rearrangements, genes, and fragile sites in cancer: Clinical and biological implications. In: DeVita V, Hellman S, Rosenberg S (eds) Important Advances in Oncology. J.B. Lippincott, Philadelphia, 1986, pp 93–128

    Google Scholar 

  133. Yunis JJ, Hoffman WR: Fragile sites as a mechanism in carcinogenesis. Cancer Bull 41: 283–292, 1989

    Google Scholar 

  134. Paget S: The distribution of secondary growths in cancer of the breast. The Lancet 1: 571–573, 1889

    Google Scholar 

  135. Hart IR: ‘Seed and soil’ revisited: Mechanisms of site-specific metastasis. Cancer Metastasis Rev 1: 5–16, 1982

    Google Scholar 

  136. Hovak E, Darling DL, Tarin D: Analysis of organ-specific effects on metastatic tumor formation by studies in vitro. J Natl Cancer Inst 76: 913–922, 1986

    Google Scholar 

  137. Naito S, von Eschenbach AC, Giavazzi R, Fidler IJ: Growth and metastasis of tumor cells isolated from a human renal cell carcinoma implanted into different organs of nude mice. Cancer Res 46: 4109–4115, 1986

    Google Scholar 

  138. Naito S, Giavazzi R, Fidler IJ: Correlation between the in vitro interaction of tumor cells with an organ environment and metastatic behavior in vivo. Invasion and Metastasis 7: 16–29, 1987

    Google Scholar 

  139. Nicolson GL, Dulski K: Organ-specificity of metastatic tumor colonization is related to organ-selective growth properties of malignant cells. Int J Cancer 38: 289–294, 1986

    Google Scholar 

  140. Price JE, Daniels LM, Campbell DE, Giavazzi R: Organ distribution of experimental metastasis of a human colorectal carcinoma injected in nude mice. Clin Expl Metastasis 7: 55–68, 1989

    Google Scholar 

  141. Cavanaugh PG, Nicolson GL: Purification and some properties of a lung-derived growth factor that differentially stimulates the growth of tumor cells metastatic to the lung. Cancer Res 49: 3928–3933, 1989

    Google Scholar 

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  1. Department of Cell Biology, The University of Texas M.D. Anderson Cancer Center, 77030, Houston, Texas, USA

    Sen Pathak

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Pathak, S. Cytogenetic abnormalities in cancer: with special emphasis on tumor heterogeneity. Cancer Metast Rev 8, 299–318 (1990). https://doi.org/10.1007/BF00052606

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