Data from a population-based study of newly diagnosed cases of prostate cancer (n=362) and age-matched controls (n=685) conducted in Utah (United States) between 1983 and 1986 were used to determine if cigarette smoking, alcohol, coffee, tea, caffeine, and theobromine were associated with prostate cancer risk. These factors were examined since their use differs in the Utah population, which is comprised predominantly of members of the Church of Jesus Christ of Latter-day Saints (LDS or Mormon), from most other populations. Pack-years of cigarettes smoked, alcohol intake, and consumption of alcohol, coffee, tea, and caffeine were not associated with prostate cancer risk. Compared with men with very low levels of theobromine intake, older men consuming 11 to 20 and over 20 mg of theobromine per day were at increased risk of prostate cancer (odds ratio [OR] for all tumors = 2.06, 95 percent confidence interval [CI]=1.33–3.20, and OR=1.47, CI=0.99–2.19, respectively; OR for aggressive tumors = 1.90, CI=0.90–3.97, and OR=1.74, CI=0.91–3.32, respectively). We present biological mechanisms for a possible association between prostate cancer and theobromine. This finding needs further exploration in studies with a wider range of theobromine exposures and more men with aggressive tumors.
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West DW, Slattery ML, Robison LM, French TK, Mahoney AW. Adult dietary intake and prostate cancer risk in Utah: A case-control study with special reference to aggressive tumors. Cancer Causes Control 1991; 2: 85–94.
Mills PK, Beeson WL, Phillips RL, Fraser GE. Cohort study of diet, lifestyle, and prostate cancer in Adventist men. Cancer 1989; 64: 598–604.
Kolonel LN, Yoshizaua CN, Hankin JH. Diet and prostatic cancer: a case-control study in Hawaii. Am J Epidemiol 1988; 127: 999–1012.
McWhorter B, ed. Cancer in Utah. Salt Lake City, UT: Utah Cancer Registry, 1992.
Slattery ML, West DW, Robison LM et al. Tobacco, alcohol, coffee, and caffeine as risk factors for colon cancer in a low-risk population. Epidemiology 1990; 1: 141–5.
Slattery ML, Schumacher MC, West DW, Robison LM. Smoking and bladder cancer: the modifying effect of cigarettes on other factors. Cancer 1988; 61: 194–200.
Hartge P, Brinton LA, Rosenthal JF, Cahill JI, Hoover RN, Waksberg J. Random digit dialing in selecting a population-based control group. Am J Epidemiol 1984; 120: 825–33.
Waksberg J. Sampling methods for random digit dialing. J Am Stat Assoc 1978; 73: 40–6.
Slattery ML, Schumacher MC, West DW, Robison LM, French TK. Food consumption trends between adolescent and adult years and subsequent risk of prostate cancer. Am J Clin Nutr 1990; 52: 752–7.
Dhom G. Epidemiologic aspects of latent and clinically manifest carcinoma of the prostate. J Cancer Res Clin Oncol 1983; 106: 210–8.
Greenwald P. Prostate. In: Schottenfeld D, Fraumeni JFJr, eds. Cancer Epidemiology and Prevention. Philadelphia, PA: WB Saunders Co., 1982; 938–46.
Rothman K. Modern Epidemiology. Boston, MA: Little, Brown and Company, 1986; Chapters 11 and 12.
Hsing AW, McLaughlin JK, Schuman LM, et al. Diet, tobacco use, and fatal prostate cancer: results from the Lutheran Brotherhood Cohort Study. Cancer Res 1990; 50: 6836–40.
Walker ARP, Walker BF, Tsotetsi NG, Sebitso C, Siwedi D, Walker AJ. Case-control study of prostate cancer in Black patients in Soweto, South Africa. Br J Cancer 1992; 65: 438–41.
Ross RK, Shimizu H, Pagnini-Hill A, et al. Case-control studies of prostate cancer in blacks and whites in Southern California. JNCI 1987; 78: 869–74.
Kinlen LJ, Willows AN, Goldblatt P, Yudkin J. Tea consumption and cancer. Br J Cancer 1988; 58: 397–401.
Heilbrun LK, Nomura A, Stemmermann GN. Black tea consumption and cancer risk: A prospective study. Br J Cancer 1986; 54: 677–83.
Honda GD, Bernstein L, Ross RK, Greenland S, Gerkins V, Henderson BE. Vasectomy, cigarette smoking, and age at first sexual intercourse as risk factors for prostate cancer in middle-aged men. Br J Cancer 1988; 57: 326–31.
Ames BN. Dietary carcinogens and anticarcinogens. Science 1983; 221: 1256–64.
Gans JH. Dietary influences on theobromine-induced toxicity in rats. Toxicol Appl Pharmacol 1982; 63: 312–20.
Renner HW. Sister chromatid exchanges induced by methylxanthines contained in coffee, tea, and cocoa. Experientia 1982; 38: 600.
Bishop DT, Meikel AW, Slattery ML, et al. The effect of nutritional factors on sex hormone levels in male twins. Genetic Epidemiol 1988; 5: 43–59.
Dr Slattery is with the University of Utah School of Medicine, Salt Lake City, UT, USA. Dr West is with the Northerm California Cacer Center, Alameda, CA, USA. Address correspondence to Dr Slattery, Department of Family and Preventive Medicine, University of Utah School of Medicine, 50 North Medical Drive, Salt Lake City, UT 84132, USA. This study was supported in part by grant number CA 34804 from the US National Cancer Institute.
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Slattery, M.L., West, D.W. Smoking, alcohol, coffee, tea, caffeine, and theobromine: risk of prostate cancer in Utah (United States). Cancer Causes Control 4, 559–563 (1993). https://doi.org/10.1007/BF00052432
- prostate cancer
- United States