A population-based case-control interview study investigated whether reproductive factors are related to the striking female-over-male excess of thyroid cancer among women of reproductive age in Los Angeles County, CA (United States). As a separate component of that study, mothers of 153 cases and 140 controls who were age 40 or younger at diagnosis or reference date were interviewed by telephone to determine the significance of family and maternal risk factors in the subsequent development of thyroid cancer among the daughters. More case than control mothers experienced miscarriage prior to the index pregnancy (odds ratio [OR]=2.0, 95 percent confidence interval [CI]=1.1–3.5). Increased risk was associated with family history of thyroid cancer or other thyroid disease (OR=2.1, CI=1.2–3.6). More control than case mothers smoked during the index pregnancy (OR=0.6, CI=0.4–1.0); however, among mothers who smoked, case mothers smoked more. Case mothers experienced a greater increase in weight from minimum adult weight to weight at index pregnancy (P for trend = 0.01). Reports from mothers also confirmed the risk associated with the daughter's exposure to ionizing radiation from birth through adolescence; ionizing radiation remains the best-established risk factor for thyroid cancer.
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Preston-Martin, S, Bernstein, L, Pike, MC, Maldonado, AA, Henderson, BE. Thyroid cancer among young women related to prior thyroid disease and pregnancy history. Br J Cancer 1987; 55: 191–5.
Breslow, NE, Day, NE, eds. Statistical Methods in Cancer Research: Vol. 1. The Analysis of Case-control Studies. Lyon, France: International Agency for Research on Cancer, 1980; IARC Sci. Pub. No. 32.
Preston-Martin, S, Jin, F, Duda, MJ, Mack, WJ. A casecontrol study of thyroid cancer in women under age 55 in Shanghai (People's Republic of China). Cancer Causes Control 1993; 4: 431–40.
Ron, E, Kleinerman, RA, Boice, JDJr, LiVolsi, VA, Flannery, JT, Fraumeni, JFJr. A population-based case-control study of thyroid cancer. JNCI 1987; 79: 1–12.
Levi, F, Franceschi, S, Gulie, C, Negri, E, La Vecchia, C. Female thyroid cancer: the role of reproductive and hormonal factors in Switzerland. Oncology 1993; 50: 309–15.
Kolonel, LN, Hankin, JH, Wilkens, LR, Fukunaga, FH, Hinds, MW. An epidemiologic study of thyroid cancer in Hawaii. Cancer Causes Control 1990; 1: 223–34.
Winikoff, D, Malinkek, M. The predictive value of thyroid “test profile” in habitual abortion. Br J Obstet Gynecol 1975; 82: 760–6.
Man, EB, Heinemann, M, Johnson, CE, Leary, DC, Peters, JB. The precipitable iodine of serum in normal pregnancies and its relation to abortions. J Clin Invest 1951; 30: 137–50.
Potter, JD. Hypothyroidism and reproductive failure. Surg Gynecol Obstet 1980; 150: 251–5.
Galanti, MR, Lambe, M, Ekbom, A, Sparen, P, Pettersson, B. Parity and risk of thyroid cancer: a nested case-control study of a nationwide Swedish cohort. Cancer Causes Control 1995; 6: 37–44.
Ron, E, Kleinerman, RA, LiVolsi, VA, Fraumeni, JFJr. Familial nonmedullary thyroid cancer. Oncology 1991; 48: 309–11.
Henderson, BE, Ross, RK, Pike, MC, Casagrande, JT. Endogenous hormones as a major factor in human cancer. Cancer Res 1982; 42: 3232–9.
Fisher, DA. Thyroid physiology in the perinatal period and during childhood. In: Ingbar, SH, Braverman, LE, eds. Werner's The Thyroid, 5th Ed. Philadelphia, PA (USA): JB Lippincott, 1986: 1387–95.
McTiernan, AM, Weiss, NS, Daling, JR. Icidence of thyroid cancer in women in relation to previous exposure to radiation therapy and history of thyroid disease. JNCI 1984; 73: 575–81.
Franceschi, S, Fassina, A, Talamini, R, et al. Risk factors for thyroid cancer in Northern Italy. Int J Epidemiol 1989; 18: 578–84.
Morabia, A, Wynder, EL. Epidemiology and natural history of breast cancer. Implications for the body weight-breast cancer controversy. Surg Clin North Am 1990; 70: 739–52.
Goodman, MT, Kolonel, LN, Wilkens, LR. The association of body size, reproductive factors and thyroid cancer. Br J Cancer 1992; 66: 1180–4.
McTiernan, AM, Weiss, NS, Daling, JR. Incidence of thyroid cancer in women in relation to known or suspected risk factors for breast cancer. Cancer Res 1987; 47: 292–5.
James, WP. Epidemiology of obesity. Int J Obesity 1992; 16: S23–6.
McTiernan, AM, Weiss, NS, Daling, JR. Incidence of thyroid cancer in women in relation to reproductive and hormonal factors. Am J Epidemiol 1984; 120: 423–35.
Christensen, SB, Ericsson, UB, Janzon, L, Tibblin, S, Melander, A. Influence of cigarette smoking on goiter formation, thyroglobulin, and thyroid hormone levels in women. J. Clin Endocrin Metab 1984; 58: 615–8.
Ericsson, UB, Lindgaerde, F. Effects of cigarette smoking on thyroid function and the prevalence of goitre, thyrotoxicosis and autoimmune thryoiditis. J Int Med 1991; 229: 67–71.
Prummel, MF, Wiersinga, WM. Smoking and risk of Graves' disease. JAMA 1993; 269: 479–82.
Tellez, M, Cooper, J, Edmonds, C. Graves' ophthalmopathy in relation to cigarette smoking and ethnic origin. Clin Endocrinol 1992; 36: 291–4.
Istvan, JA, Cunningham, TW, Garfinkel, L. Cigarette smoking and body weight in the Cancer Prevention Study I. Int J Epidemiol 1992; 21: 849–53.
Bernstein, L, Pike, MC, Lobo, RA, Depue, RH, Ross, RK, Henderson, BE. Cigarette smoking in pregnancy results in marked decrease in maternal hCG and oestradiol levels. Br J Obstet Gynaecol 1989; 96: 92–6.
Daniel, M, Martin, AD, Faiman, C. Sex hormones and adipose tissue distribution in premenopausal smokers. Int J Obes 1992; 16: 245–54.
Jick, J, Porter, J, Morrison, AS. Relation between smoking and the age of natural menopause. Lancet 1977; 1: 1354–5.
Melander, A, Nordenskjoeld, E, Lundh, B, Thorell, J. Influence of smoking on thyroid activity. Acta Med Scand 1981; 209: 41–3.
Shore, RE, Hildreth, N, Dvoretsky, P, Andresen, E, Moseson, M, Pasternack, B. Thyroid cancer among persons given X-ray treatment in infancy for an enlarged thymus gland. Am J Epidemiol 1993; 137: 1068–80.
Ron, E, Modan, B, Preston, D, Alfandary, E, Stovall, M, Boice, JDJr. Thyroid neoplasia following low-dose radiation in childhood. Radiat Res 1989; 120: 516–31.
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This study was funded by program project CA17054 from the National Cancer Institute.
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Paoff, K., Preston-Martin, S., Mack, W.J. et al. A case-control study of maternal risk factors for thyroid cancer in young women (California, United States). Cancer Causes Control 6, 389–397 (1995). https://doi.org/10.1007/BF00052178
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DOI: https://doi.org/10.1007/BF00052178