The dietary data from case-control studies of breast, prostate, and lung cancer in Hawaii revealed that saturated fat was a risk factor for these malignancies. The dietary intakes from the three studies were used to calculate the attributable risk (AR) due to saturated fat. For all ethnic groups combined, the ARs for the highest quartiles of intake were 14.9 percent for female breast cancer, 13.0 percent for prostate cancer, and 23.1 percent for male lung cancer. Our results suggested that a reduction of saturated fat to the lowest quartiles of intake could result in a 10 to 20 percent decrease in risk for these three cancers in Hawaii. We also examined the ethnic-specific risks associated with saturated fat consumption among the Japanese and the Caucasians in the three studies. The ARs for the highest quartiles of intake were notably higher among the Caucasians than the Japanese, primarily due to the difference in their dietary patterns. Although the calculated AR due to saturated fat was higher among the Caucasians than among the Japanese, all persons in the population would derive considerable benefit by reducing their intake of this nutrient.
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References
Doll R, Peto R. The causes of cancer: quantitative estimates of avoidable risks of cancer in the United States today. JNCI 1981; 66: 1191–308.
Committee on Diet, Nutrition, and Cancer. National Research Council. Diet, Nutrition, and Cancer. Washington, DC: National Academy Press, 1982.
Wynder EL, Gori GB. Contribution of the environment to cancer incidence: an epidemiologic exercise. JNCI 1977; 58: 825–32.
Committee on Diet and Health, Food and Nutrition Board. National Research Council. Diet and Health. Implications for Reducing Chronic Disease Risk. Washington, DC: National Academy Press, 1989.
Public Health Service. US Department of Health and Human Services. The Surgeon General's Report on Nutrition and Health. Washington, DC: US Government Printing Office, 1988.
Howe GR, Hirobata T, Hislop GT, et al. Dietary factors and risk of breast cancer: combined analysis of 12 case-control studies. JNCI 1990; 82: 561–69.
Prentice RL, Sheppard L. Dietary fat and cancer: consistency of the epidemiologic data, and disease prevention that may follow from a practical reduction in fat consumption. Cancer Causes Control 1990; 1: 81–97.
Hirohata T, Nomura AMY, Hankin JH, et al. An epidemiologic study on the association between diet and breast cancer. JNCI 1987; 78: 595–600.
Kolonel LN, Yoshizawa CN, Hankin JH. Diet and prostatic cancer: a case-control study in Hawaii. Am J Epidemiol 1988; 127: 999–1012.
Goodman MT, Kolonel LN, Yoshizawa CN, et al. The effect of dietary cholesterol and fat on the risk of lung cancer in Hawaii. Am J Epidemiol 1988; 128: 1241–55.
Young JL Jr, Percy CL, Asire AJ, eds. Surveillance, epidemiology, end-results: incidence and mortality data 1973–1977. NCI Monogr 1981; 57: 1–1082.
Hankin JH. 23rd Lenna Frances Cooper Memorial Lecture: a diet history method for research, clinical, and community use. J Am Dietet Assoc 1986; 86: 868–75.
Hankin JH, Wilkens LR, Kolonel LN, et al. Validation of a quantitative diet history method in Hawaii. Am J Epidemiol 1991; 133: 616–28.
Hankin JH, Nomura AMY, Lee J, et al. Reproducibility of a diet history questionnaire in a case-control study of breast cancer. Am J Clin Nutr 1983; 37: 981–5.
Hankin JH, Yoshizawa CN, Kolonel LN. Reproducibility of a diet history in older men in Hawaii. Nutr Cancer 1990; 13: 129–40.
US Department of Agriculture. Composition of Foods: Raw, Processed, Prepared. (Data set 8–1–1). Washington, DC: Agricultural Research Service, 1972.
US Department of Agriculture. Composition of Foods: Raw, Processed, Prepared. Handbooks 8–1 to 8–21. Washington, DC: Agricultural Research Service, 1976–1989.
Breslow NE, Day NE. Statistical Methods in Cancer Research. Vol. I. The Analysis of Case-control Studies. Lyon, France: International Agency for Research on Cancer, 1980; IARC Sci. Pub. No. 32.
Carroll MD, Abraham S, Dresser CM. Dietary intake source data: United States 1976–1980. In: Vital and Health Statistics. Series 11-No. 231. Washington, DC: National Center for Health Statistics. Public Health Service, 1983.
Graham S, Haughey B, Marshall J, et al. Diet in the epidemiology of carcinoma of the prostate gland. JNCI 1983; 70: 687–92.
Heshmat MY, Kaul L, Kovi J, et al. Nutrition and prostate cancer: a case-control study. Prostate 1985; 6: 7–17.
West DW, Slattery ML, Robison LM, et al. Adult dietary intake and prostate cancer risk in Utah: a case-control study with special emphasis on aggressive tumors. Cancer Causes Control 1991; 2: 85–94.
Byers TE, Graham S, Haughey BP, et al. Diet and lung cancer risk: findings from the Western New York diet study. Am J Epidemiol 1987; 125: 351–63.
Wynder EL, Hebert JR, Kabat GC. Association of dietary fat and lung cancer. JNCI 1987; 79: 631–7.
Kolonel LN, Hankin JH, Nomura AM, et al. Dietary fat intake and cancer incidence among five ethnic groups in Hawaii. Cancer Res 1981; 41: 3727–8.
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Authors are with the Epidemiology Program, Cancer Research Center of Hawaii, University of Hawaii, 1236 Lauhala Street, Honolulu, HI 96813, USA. Address correspondence to Dr Hankin. This study was supported in part by NIH Grant PO1 CA 33619.
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Hankin, J.H., Zhao, L.P., Wilkens, L.R. et al. Atributable risk of breast, prostate, and lung cancer in Hawaii due to saturated fat. Cancer Causes Control 3, 17–23 (1992). https://doi.org/10.1007/BF00051907
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DOI: https://doi.org/10.1007/BF00051907