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Leukemia, lymphoma, and multiple myeloma following selected medical conditions

Cancer Causes & Control volume 3, pages 449–456 (1992)Cite this article

The role of selected prior medical conditions in the etiology of hematopoietic malignancies was examined in a case-control study of members of two regional branches of the Kaiser Permanente Medical Care Program (USA). Past history of chronic infectious, autoimmune, allergic, and musculoskeletal disorders was abstracted from medical records for leukemia (n = 299), non-Hodgkin's lymphoma (NHL, n = 100), and multiple myeloma (n = 175) cases and matched controls (n = 787). Little difference was found between cases and controls for most of the chronic conditions evaluated, including sinusitis, carbuncles, urinary tract infections, pelvic infections, herpes zoster, asthma, rheumatoid arthritis, psoriasis, bursitis, and gout. Only three statistically significant elevated risks were found, i.e., with combined disc disease myeloma among patients with prior eczema and disk and other musculoskeletal conditions, and NHL following tuberculosis. Only two of these associations showed consistent patterns by sex and geographic region (myeloma with eczema and with musculoskeletal conditions). While prior history of eczema and musculoskeletal conditions may slightly increase risk of myeloma, this study provided little if any support for an association of chronic infectious, autoimmune, allergic, and musculoskeletal conditions with subsequent occurrence of the leukemias or NHL. Additionally, these data did not support a role for chronic antigenic stimulation, as defined in previous epidemiologic studies, in the etiology of hematopoietic malignancies.

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Authors
  1. Michele Morin Doody
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  2. Martha S. Linet
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  3. Andrew G. Glass
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  4. Gary D. Friedman
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  5. Linda M. Pottern
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  6. John D. Boice Jr
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  7. Joseph F. Fraumeni Jr
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Additional information

Ms Doody and Drs Linet, Pottern, Boice, and Fraumeni are with the Epidemiology and Biostatistics Program, National Cancer Institute. Dr Glass is with the Kaiser Permanente Medical Care Program, Northwest Region, Portland, Oregon, USA. Dr Friedman is with the Kaiser Permanente Medical Care Program, Northern California Region, Oakland, California, USA. Address correspondence to Ms Doody, Radiation Epidemiology Branch, National Cancer Institute, Executive Plaza North, Room 408, Bethesda, MD 20892, USA. This research was supported in part by National Cancer Institute contracts NO1-CP-01047, NO1-CP-01054, NO1-CP-11009, NO1-CP-11037, NO1-CP-31035, and NO1-CP-61006.

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Doody, M.M., Linet, M.S., Glass, A.G. et al. Leukemia, lymphoma, and multiple myeloma following selected medical conditions. Cancer Causes Control 3, 449–456 (1992). https://doi.org/10.1007/BF00051358

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  • DOI: https://doi.org/10.1007/BF00051358

Key words

  • Allergy
  • autoimmune diseases
  • epidemiology
  • health maintenance organizations
  • infectious diseases
  • leukemia
  • lymphoma
  • multiple myeloma
  • musculoskeletal diseases
  • USA