International comparisons show that populations having a high consumption of fish experience low incidence of breast cancer. We compared death rates from breast cancer among socioeconomic groups in a prospective study of 533,276 Norwegian women aged 35–54 years who were followed from 1970 through 1985. Compared with the reference group (wives of unskilled workers) the fishermen's wives had a decreased risk of breast cancer with a relative risk (RR) of 0.67 (95% confidence interval [CI]=0.47−0.94) adjusted for age and the number of children. Among fishermen's wives who were parous, adjustment for age at first birth gave an RR of 0.62 (CI=0.43–0.91). This study supports the hypothesis that certain aspects of diet, i. e., fish consumption, may be associated with lower breast-cancer mortality.
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References
Armstrong B, Doll R. Environmental factors and cancer incidence and mortality in different countries with special reference to dietary practices. Int J Cancer 1975; 15: 617–31.
Gray GE, Pike MC, Henderson BE. Breast-cancer incidence and mortality rates in different countries in relation to known risk factors and dietary practices. Br J Cancer 1979; 39: 1–7.
Committee on Diet, Nutrition and Cancer, Assembly of Life Sciences, National Research Council. Diet, Nutrition and Cancer. Washington, DC: National Academy Press, 1983.
Howe GR, Hirohata T, Hislop TG, et al. Dietary factors and risk of breast cancer: combined analysis of 12 casecontrol studies. JNCI 1990; 82: 561–9.
Willett WC, Stampfer MJ, Colditz GA, Rosner BA, Hennekens CH, Speizer FE. Dietary fat and the risk of breast cancer. N Engl J Med 1987; 316: 22–8.
Jones DY, Schatzkin A, Green SB, et al. Dietary fat and breast cancer in the National Health and Nutrition Examination Survey. I. Epidemiologic follow-up study. JNCI 1987; 79: 465–71.
Vatten LJ, Solvoll K, Løken EB. Frequency of meat and fish intake and risk of breast cancer in a prospective study of 14,500 Norwegian women. Int J Cancer 1990; 46: 12–5.
Richardson S, Gerber M, Cenèe S. The role of fat, animal protein and some vitamin consumption in breast cancer: a case-control study in southern France. Int J Cancer 1991; 48: 1–9.
Ingram DM, Nottage E, Roberts T. The role of diet in the development of breast cancer: a case-control study of patients with breast cancer, benign epithelial hyperplasia and fibrocystic diease of the breast. Int J Cancer 1991; 64: 187–91.
Gerber M, Richardson S, de Paulet PC, Pujol H, de Paulet AC. Relationship between vitamin E and polyunsaturated fatty acids in breast cancer. Cancer 1989; 64: 2347–53.
Karmali RA. n-3 Fatty acids and cancer. J Intern Med 1989; 225 (suppl. I): 197–200.
Kaizer L, Boyd NF, Kriukov V, Tritchler D. Fish consumption and breast cancer risk: an ecological study. Nutr Cancer 1989; 12: 61–8.
Wan J M-F, Istfan NW, Chu CC, Blackburn GL, Bistrian BR. Comparative effects of omega-3 and omega-6 polyunsaturated fatty acids on protein metabolism in rats bearing the mammary adenocarcinoma. Metabolism 1991; 40: 577–84.
Kromann N, Green A. Epidemiological studies in the Upernavik district, Greenland. Incidence of some chronic diseases 1950–1974. Acta Med Scand 1980; 208: 401–6.
Glomset JA. Fish, fatty acids, and human disease. N Engl J Med 1985; 312: 1253–4.
Carroll KK. Biological effects of fish oils in relation to chronic diseases. Lipids 1986; 21: 731–2.
Bang HO, Dyerberg J, Hjørne N. The composition of food consumed by Greenland Eskimos. Acta Med Scand 1976; 200: 69–73.
Bjerregaard P, Dyerberg J. Mortality from ischaemic heart disease and cerebrovascular disease in Greenland. Int J Epidemiol 1988; 17: 514–9.
Nielsen NH, Hansen JPH. Breast cancer incidence in Greenland—selected epidemiological, clinical and histological features. J Cancer Res Clin Oncol 1980; 98: 287–99.
Jurkowski JJ, Cawe WJ Jr. Dietary effects of menhaden oil on the growth and membrane lipid composition of rat mammary tumors. JNCI 1985; 74: 145–50.
Karmali RA, Marsh J, Fushs C. Effect of omega-3 fatty acids on growth of a rat mammary tumor. JNCI 1984: 73: 457–61.
Stampfer MJ, Willett WC, Colditz GA, Speizer FE. Intake of cholesterol, fish and specific types of fat in relation to risk of breast cancer. In: Lands WEM, ed. Proceedings of the AOCS Short Course on Polyunsaturated Fatty Acids and Eicosanoids; 1987 May 14–17; Biloxi. Champaign, IL: American Oil Chemists' Society, 1987: 248–52.
Central Bureau of Statistics of Norway. Forbruk av Fisk 1984 (Fish Consumption in Norway 1984). Oslo: Central Bureau of Statistics, 1986.
Solvang A, Eggen Øgrim M. Dietary Surveys in Gramvik, Northern Norway. Oslo: Landsforeningen for Kosthold og Helse, 1963; Report No. 4.
Bardølsgaard K, Eggen Øgrim M. Dietary Surveys in Havøysund, Northern Norway. Oslo: Landsforeningen for Kosthold og Helse, 1963; Report No. 5.
Bække U, Laeskogen BM, Eggen Øgrim M. Dietary Surveys in Kåfjord. Oslo: Landsforeningen for Kosthold og Helse, 1968; Report No. 12.
Kelsey JL, Hildreth NG. Breast and Gynecologic Cancer Epidemiology. Boca Raton, FL: CRC Press, 1983.
Lund E. Childbearing in marriage and mortality from breast cancer in Norway. Int J Epidemiol 1990; 19: 527–31.
Vassenden K. Folke-og Boligtellingene 1960, 1970 og 1980 (The Census 1960, 1970 and 1980). Oslo: Central Bureau of Statistics, 1987; Report 87/2.
Central Bureau of Statistics. Standard Classification of Socioeconomic Status (Standarder for Norsk Statistikk). Oslo: Central Bureau of Statistics, 1984.
Lund E. Pilot study for the evaluation of completeness of reporting to the Cancer Registry. In: Incidence of Cancer in Norway 1978. Oslo: Cancer Registry of Norway, 1981: 11–4.
World Health Organization. International Classification of Diseases, Eighth Revision. Geneva: WHO, 1967.
Breslow NE, Day NE. Statistical Methods in Cancer Research. Vol II—The Design and Analysis of Cohort Studies. Lyon, France: International Agency for Research on Cancer, 1987; IARC Sci. Pub. No. 82.
Numerical Algorithms Group Ltd. The Generalized Linear Interactive Modeling (GLIM) System. Oxford, UK: Royal Statistical Society, 1987.
Liberatos P, Link BG, Kelsey JL. The measurement of social class in epidemiology. Epidemiol Rev 1988; 10: 87–121.
Simonsen T, Vårtun Å, Lyngmo V, Nordøy A. Coronary heart disease, serum lipids, platelets and dietary fish in two communities in Northern Norway. Acta Med Scand 1987; 222: 237–45.
Brunborg H. Cobort and Period Fertility for Norway 1845–1985. Oslo: Central Bureau of Statistics, 1988; Report 88/4.
Lund E, Koster Jacobsen B. Education and breast cancer mortality: experience from a large Norwegian cohort study. Cancer Causes Control 1991; 2: 235–8.
Leaf A, Weber PC. Cardiovascular effects of n-3 fatty acids. N Engl J Med 1988; 318: 549–57.
Bønaa KH, Bjerve KS, Nordøy A. Habitual fish consumption, plasma phospholipid fatty acids, and serum lipids: the Tromsø study. Am J Clin Nutr 1992; 55: 1126–34.
Dolecek TA, Grandits G. Dietary polyunsaturated fatty acids and mortality in the Multiple Risk Factor Intervention Trial (MRFIT). Simpoulos AP, Kifer RR, Martin RE, Barlow SM, eds. Health Effects of Omega 3 Polyunsaturated Fatty Acids in Seafoods. World Rev Nutr Diet. Basel: Karger, 1991; 66: 205–16.
Lee TH, Hoover RL, Williams JD, et al. Effect of dietary enrichment with eicosapentaenoic and docosahexaenoic acids on in vitro neutrophil and monocyte leukotriene generation and neutrophil function. N Engl J Med 1985; 312: 1217–24.
Endres S, Ghorbani BS, Kelley VE, et al. The effect of dietary supplementation with n-3 polyunsaturated fatty acids on the synthesis of interleukin-1 and tumor necrosis factor by mononuclear cells. N Engl J Med 1989; 320: 265–71.
Fox PL, DiCorletto PE. Fish oils inhibit endothelial cell production of platelet-derived growth factor-like protein. Science 1988; 241: 453–6.
Galli C, Butrum R. Dietary omega-3 fatty acids and cancer: an overview. In: Simopoulos AP, Kifer RR, Martin RE, Barlow SM, eds. Health Effects of Omega 3 Polyunsaturated Fatty Acids in Seafoods. World Rev Nutr Diet. Basel: Karger, 1991; 66: 446–61.
Burns CP, Wagner BA. Heightened susceptibility of fish oil polyunsaturate-enriched neoplastic cells to ethane generation during lipid peroxidation. J Lipid Res 1991; 32: 79–87.
Jenski LJ, Sturdevant LK, Ehringer WD, Stillwell W. Omega-3 fatty acids increase spontaneous release of cytosolic components from tumor cells. Lipids 1991; 26: 353–8.
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Drs Lund and Bønaa are with the Institute of Community Medicine, University of Tromsø, Tromsø, Norway. Address correspondence to Dr Lund, Institute of Community Medicine, University of Tromsø, N-9037 Tromsø, Norway.
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Lund, E., Bønaa, K.H. Reduced breast cancer mortality among fishermen's wives in Norway. Cancer Causes Control 4, 283–287 (1993). https://doi.org/10.1007/BF00051323
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DOI: https://doi.org/10.1007/BF00051323