Summary
Second-generation agents include new dihydropyridines, such as amlodipine, felodipine, isradipine, nicardipine, nimodipine, nisoldipine, and nitrendipine. Verapamil-like agents include tiapamil, gallopamil, and anipamil. Among the diphenylalkylamines, bepridil is of special interest. New preparations of existing agents include slow-release formulations of nifedipine, verapamil, and diltiazem. From all these agents will be selected those that are longer-acting and provide higher vascular selectivity.
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Opie, L.H. Calcium channel antagonists part V: Second-generation agents. Cardiovasc Drug Ther 2, 191–203 (1988). https://doi.org/10.1007/BF00051234
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DOI: https://doi.org/10.1007/BF00051234