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The metabolism and genetic regulation of lipids in the oleaginous yeast Yarrowia lipolytica

  • Didiana Gálvez-López
  • Bianca Chávez-Meléndez
  • Alfredo Vázquez-Ovando
  • Raymundo Rosas-Quijano
Biotechnology and Industrial Microbiology - Review
  • 3 Downloads

Abstract

The biotechnological potential of Yarrowia lipolytica, as a single cell oil-producing microorganism, is presented in this review. Although initially this yeast species was considered as a lipid-degrading, recently, it was reclassified as a lipid-producing microorganism, since it has been reported to be capable of accumulating diverse desirable fatty acids after metabolic pathway engineering. In the first part of the present document, a general revision of the oil metabolic pathways and the capacity of oil production in Y. lipolytica is presented. The single cell oil produced by these metabolic engineering strategies has been designed by optimization, introduction, or suppression of new pathways to increase yield on lipid production. Later on, the genetic regulation systems and the lipid composition generated by this yeast for industrial purposes are discussed. These lipids could be safely used in the chemical food and biofuel industries, due to their high proportion of oleic acid. This document emphasizes in the overviewing at Y. lipolytica as an ideal oil cell factory, and as an excellent model to produce single cell oil.

Keywords

Lipid metabolism Citric acid Lipases Hydrophobic substrates Y. lipolytica 

Notes

Acknowledgements

The authors thanks to the Mexican Instituto Politécnico Nacional, through SIP funding, for its contribution in the knowledge generation about this microorganism. Likewise, we are grateful for the scholarships granted by CONACYT Mexico.

Compliance with ethical standards

Conflict of interest

The authors declare not having a conflict of interests in this article’s publishing.

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Copyright information

© Sociedade Brasileira de Microbiologia 2018

Authors and Affiliations

  • Didiana Gálvez-López
    • 1
  • Bianca Chávez-Meléndez
    • 2
  • Alfredo Vázquez-Ovando
    • 1
  • Raymundo Rosas-Quijano
    • 1
  1. 1.Instituto de BiocienciasUniversidad Autónoma de ChiapasTapachulaMéxico
  2. 2.Unidad Académica MultidisciplinariaUniversidad Autónoma de TamaulipasReynosaMéxico

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