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Applicable features of electroencephalogram for ADHD diagnosis

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Abstract

Purpose

Attention-deficit/hyperactivity disorder (ADHD) is a neuro-developmental and psychiatric disorder, which affects 11% of children around the world. Several linear and nonlinear biomarkers from electroencephalogram (EEG) signals have been proposed for diagnosis of ADHD to date. However, the determination of which type of analysis gives us the best feature and biomarker to diagnose ADHD is still controversial. In this study, we aimed to evaluate and compare several categories of features, extracted from EEG signals, for diagnosis of ADHD.

Methods

Thirty 7–12-year-old children fulfilling the DSM5 criteria for ADHD and thirty healthy children underwent a noninvasive EEG evaluation at resting-state. After preprocessing, five categories of features including morphological, time, frequency, time-frequency, and nonlinear features were extracted from EEGs. The efficacy of each feature category in ADHD diagnosis was determined using statistical analysis, receiver operating characteristic (ROC) curves, and evidential K-nearest neighbor (EKNN) classifier.

Results

Statistical analyses showed that 13.15, 13.68, 14.47, 14.03, and 34.73% of extracted features were significant (p < 0.05) in morphological, time, frequency, time-frequency, and nonlinear domains, respectively. The largest AUC values for the five morphological, time, frequency, time-frequency, and nonlinear feature categories, were 0.870, 0.796, 0.824, 0.806, and 0.899, respectively. We obtained the accuracies of 77.43% using morphological features, 74.09% using time features, 80.44% using frequency features, 78.50% using time-frequency features, and 86.40% using nonlinear features.

Conclusion

Our results showed that EEG nonlinear analysis is a good quantitative tool to detect the abnormalities of the electrical activity of the brain in ADHD. This result was expected due to the complexity of the brain and the nonlinear nature of the EEG signal. Therefore, better outcomes may be expected in early diagnosis of diseases, especially psychiatric disorders, by increasing the use of nonlinear methods.

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Acknowledgments

The authors wish to acknowledge and appreciate the editorial changes made to the manuscript by Fatemeh Daftari (Department of English, Tehran University).

Funding

We acknowledge the financial support of Tehran University of Medical Sciences through a grant from Psychiatry and Psychology Research Center [grant number 40510].

Author information

Correspondence to Ali Khaleghi.

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The authors declare that they have no conflict of interest.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Khaleghi, A., Birgani, P.M., Fooladi, M.F. et al. Applicable features of electroencephalogram for ADHD diagnosis. Res. Biomed. Eng. 36, 1–11 (2020). https://doi.org/10.1007/s42600-019-00036-9

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Keywords

  • Attention-deficit/hyperactivity disorder (ADHD)
  • Electrical activity of the brain
  • Electroencephalogram (EEG)
  • Linear analysis
  • Nonlinear analysis