Nano-biogenic Hydroxyapatite Porous Scaffolds for Bone Regeneration
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Each year millions of tons of fish bones and shellfish are caught, which is a serious environmental problem. Although these wastes contain valuable minerals, their use is not widespread. The main objective of the present research is to study the use of the extracted nano-hydroxyapatite (n-HA) that is prepared from such natural resources for in vivo study in rats. In vivo tests and biochemical studies were conducted to observe the changes found in blood. Biological studies indicate that the degradation products of the biogenic nano-HA scaffolds do not cause liver disorder, kidney failure, carcinogenic effect, oxidative effects, or liberation of oxygen radicals that could destroy tissue. Neither any inflammatory effect was found.
Keywordsbiomedical biomaterials nanomaterials fish bone
The authors would like to thank the Science and Technology Development Fund (STDF), the German-Egyptian Research Fund (GERF) Projects programme, Project ID 23036 for financing the present research. The authors admit that there are no competing interests, the study does not involve human subjects and that the Science and Technology Development Fund (STDF) Egypt financed their study.
- Meeder, P.J., Eggers, C.: The history of autogenous bone grafting. Injury 25 (1994)  A2–A3Google Scholar
- Bettin, P., Doz, D.D.: The use of allografts in revision hip alloarthroplasty, in: Allografts in orthopedic practice. A.A. Czitrom, A.E. Gross (Eds.), Williams & Wilkins, Baltimore 83 (1992) 119Google Scholar
- Ahmadzadeh, E., Talebnia, F., Tabatabaei, M., Ahmadzadeh, H., Mostaghaci, B.: Osteoconductive composite graft based on bacterial synthesized hydroxyapatite nanoparticles doped with different ions: From synthesis to in vivo studies. Nanomed. Nanotechnol. Bio. L. Med. 12 (2016) 1387–1395CrossRefGoogle Scholar
- Queen, H.A., Wassif, W.S., Walker, I., Sadler, D.A., Evans, K.: Age-related biomarkers can be modulated by diet in the rat. J. Food and Nutrition Sci. 2 (2011) 884–890Google Scholar