Research center of biomanufacturing in Xi’an Jiaotong University
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Supported by National Natural Science Foundation (NSFC) of China, XJTU took the lead in the development of biofabrication. The first customized mandibular substitute surgery in the world was carried out by XJTU in 2001. In the research of customized bone substitutes, the problem of personalized precise adaptation was solved, and an in situ design methodology was proposed for customized craniomaxillofacial substitutes to promote bone in-growth. XJTU developed an integrated technology of bionic design and manufacturing technology for craniomaxillofacial substitutes. Based on this technology, specialized 3D printing equipment has been developed and commercialized, thousands of clinical cases have been carried out, and good physiological functions of patients have been restored. The research achievement on ‘Design and Manufacturing Technology of Customized Craniomaxillofacial Implants’ has won the second prize of State Award for Technological Invention in 2014 and the golden prize of the first ‘Good Design in China’ in 2015.
XJTU has also carried out the research on 3D printing of polyetheretherketone (PEEK) orthopedic implants and implemented the world’s first clinical trial of 3D-printed PEEK rib and heart plate implants. Focusing on the controllable fabrication of the typical soft and hard tissue of the human body (liver, bone), the microvascular gradient structure of soft and hard tissue fixation interface (ligament/cartilage/bone), systematic research work was carried out at three levels: the theoretical basis of bionic design, the additive manufacturing method of macro-/microstructure and the mechanisms of microstructure promoting tissue regeneration. Moreover, the 4D printing technology has been developed for the biofabricate of degradable tracheal stent and breast scaffold implant and the first international clinical trial was implemented, which stimulated the development of biofabricating technology of biodegradable engineering tissue and organ develops from benchwork to clinical applications. The academic achievements were quoted and positively evaluated by many international scholars. Finally, XJTU has achieved the very first CFDA registration certificate of customized implant in China, which is a milestone in the industrialization of 3D bioprinting technology in China.
Design and 3D printing technology of customized PEEK orthopedic implant
Software developed for customized orthopedic implants (OrthoDesign)
3D printing technology for repairing articular cartilage defects
Biofabrication and clinical application of biodegradable customize implant
Multi-nozzle 3D cell-printing technology
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