Advertisement

AuNRs/mesoporous silica/hydroxyapatite nanovehicles with thermally responsive polymeric cap for remotely controlled drug delivery

  • He Ma
  • Jun ShiEmail author
  • Xiaoyi Zhu
  • Zheng Zhang
  • Jingguo Li
  • Shaokui CaoEmail author
Original Research

Abstract

In this study, Au nanorods (AuNRs)/mesoporous silica (SiO2)/hydroxyapatite (HAP) nanovehicles with thermally responsive polymeric cap for remotely controlled drug delivery were prepared. The degradability of the hybrid nanovehicles could be greatly enhanced by introducing pH-responsive HAP into mesoporous SiO2 shell, which would result in the corrosion of HAP from the hybrid matrix in acid media. Thermal-/pH-sensitive poly(N-isopropylacrylamide-co-acrylic acid) (PNA, P(NIPAM-co-AAc)) was employed as the smart polymeric cap to control the drug delivery of hybrid nanoparticles. The in vitro drug delivery results showed that the hybrid nanoparticles displayed excellent drug loading efficiency and distinct near-infrared (NIR)–, thermal-, and pH-responsive drug delivery properties. The results of cell viability also demonstrated that the prepared P(NIPAM-co-AAc)-capped AuNRs/SiO2/HAP nanoparticles exhibited the outstanding biocompatibility. The present study provides a facile way to prepare multi-responsive nanovehicles with excellent biocompatibility and degradability by combining intelligent polymer with hybrid inorganic skeleton, which is greatly promising for remotely controllable drug release.

Graphical abstract

Keywords

Gold nanorods Hydroxyapatite P(NIPAM-co-AAc) Smart drug delivery NIR-responsiveness 

Notes

Funding information

This work was financially supported by the Henan Provincial Natural Science Foundation of China (Project 162300410257) and the National Natural Science Foundation of China (Project 20874090).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Supplementary material

42114_2019_82_MOESM1_ESM.docx (988 kb)
ESM 1 (DOCX 987 kb)

References

  1. 1.
    Zhang ZJ, Wang J, Nie X, Wen T, Ji YL, Wu XC, Zhao YL, Chen CY (2014) Near infrared laser-induced targeted cancer therapy using thermoresponsive polymer encapsulated gold nanorods. J Am Chem Soc 136:7317–7326CrossRefGoogle Scholar
  2. 2.
    Mura S, Nicolas J, Couvreur P (2013) Stimuli-responsive nanocarriers for drug delivery. Nat Mater 12:991–1003CrossRefGoogle Scholar
  3. 3.
    Meng ZQ, Wei F, Wang RH, Xia MG, Chen ZG, Wang HP, Zhu MF (2016) NIR-laser-switched in vivo smart nanocapsules for synergic photothermal and chemotherapy of tumors. Adv Mater 28(2):245–253CrossRefGoogle Scholar
  4. 4.
    Celli JP, Spring BQ, Rizvi I, Evans CL, Samkoe KS, Verma S, Pogue BW, Hasan T (2010) Imaging and photodynamic therapy: mechanisms, monitoring and optimization. Chem Rev 110:2795–2838CrossRefGoogle Scholar
  5. 5.
    Lovell JF, Liu TW, Chen J, Zheng G (2010) Activatable photosensitizers for imaging and therapy. Chem Rev 110:2839–2857CrossRefGoogle Scholar
  6. 6.
    Park BK, Lee S, Kang E, Kim K, Choi K, Kwon IC (2009) New generation of multifunctional nanoparticles for cancer imaging and therapy. Adv Funct Mater 19:1553–1566CrossRefGoogle Scholar
  7. 7.
    Brigger I, Dubernet C, Couvreur P (2012) Nanoparticles in cancer therapy and diagnosis. Adv Drug Deliv Rev 64:24–36CrossRefGoogle Scholar
  8. 8.
    Chu ZQ, Yin C, Zhang SL, Lin G, Li Q (2013) Surface plasmon enhanced drug efficacy using core-shell Au@SiO2 nanoparticles carrier. Nanoscale 5:3406–3411CrossRefGoogle Scholar
  9. 9.
    Zhang ZJ, Wang LM, Wang J, Jiang XM, Li XH, Hu ZJ, Ji YL, Wu XC, Chen CY (2012) Mesoporous silica-coated gold nanorods as a light-mediated multifunctional theranostic platform for cancer treatment. Adv Mater 24:1418–1423CrossRefGoogle Scholar
  10. 10.
    Fang L, Wang WQ, Liu Y, Xie ZG, Chen L (2017) Janus nanostructures formed by mesoporous silica coating Au nanorods for near-infrared chemo-photothermal therapy. J Mater Chem B 5:8833–8838CrossRefGoogle Scholar
  11. 11.
    Zhang Z, Shi J, Song ZX, Zhu XY, Zhu YP, Cao SK (2018) A synergistically enhanced photothermal transition effect from mesoporous silica nanoparticles with gold nanorods wrapped in reduced graphene oxide. J Mater Sci 53:1810–1823CrossRefGoogle Scholar
  12. 12.
    Lu J, Liong M, Li ZX, Zink JI, Tamanoi F (2010) Biocompatibility, biodistribution, and drug-delivery efficiency of mesoporous silica nanoparticles for cancer therapy in animals. Small 6:1794–1805CrossRefGoogle Scholar
  13. 13.
    Huang XL, Li LL, Liu TL, Hao NJ, Liu HY, Chen D, Tang FQ (2011) The shape effect of mesoporous silica nanoparticles on biodistribution, clearance, and biocompatibility in vivo. ACS Nano 5:5390–5399CrossRefGoogle Scholar
  14. 14.
    Croissant J, Cattoën X, Man MW, Gallud A, Raehm L, Trens P, Maynadier M, Durand JO (2014) Biodegradable ethylene-bis (propyl)disulfide-based periodic mesoporous organosilica nanorods and nanospheres for efficient in-vitro drug delivery. Adv Mater 26:6174–6180CrossRefGoogle Scholar
  15. 15.
    Shen S, Tang HY, Zhang XT, Ren JF, Pang ZQ, Wang DG, Gao HL, Qian Y, Jiang XG, Yang WL (2013) Targeting mesoporous silica-encapsulated gold nanorods for chemo-photothermal therapy with near-infrared radiation. Biomaterials 34:3150–3158CrossRefGoogle Scholar
  16. 16.
    Meng H, Liong M, Xia T, Li ZX, Ji ZX, Zink JI, Nel AE (2010) Engineered design of mesoporous silica nanoparticles to deliver doxorubicin and P-glyprotein siRNA to overcome drug resistance in a cancer cell line. ACS Nano 4:4539–4550CrossRefGoogle Scholar
  17. 17.
    Singh N, Karambelkar A, Gu L, Lin K, Miller JS, Chen CS, Sailor MJ, Bhatia SN (2011) Bioresponsive mesoporous silica nanoparticles for triggered drug release. J Am Chem Soc 133:19582–19585CrossRefGoogle Scholar
  18. 18.
    Park JH, Gu L, Maltzahn G, Ruoslahti E, Bhatia SN, Sailor MJ (2009) Biodegradable luminescent porous silicon nanoparticles for in vivo applications. Nat Mater 8:331–336CrossRefGoogle Scholar
  19. 19.
    Gorelikov I, Matsuura N (2008) Single-step coating of mesoporous silica on cetyltrimethyl ammonium bromide-capped nanoparticles. Nano Lett 8:369–373CrossRefGoogle Scholar
  20. 20.
    Wei J, Shi J, Wu Q, Yang L, Cao SK (2015) Hollow hydroxyapatite/polyelectrolyte hybrid microparticles with controllable size, wall thickness and drug delivery properties. J Mater Chem B 3:8162–8169CrossRefGoogle Scholar
  21. 21.
    Hao XH, Hu XX, Zhang CM, Chen SZ, Li ZH, Yang XJ, Liu HF, Jia G, Liu DD, Ge K, Liang XJ, Zhang JC (2015) Hybrid mesoporous silica-based drug carrier nanostructures with improved degradability by hydroxyapatite. ACS Nano 9:9614–9625CrossRefGoogle Scholar
  22. 22.
    Song ZX, Yang L, Shi J, Ma T, Zhang Z, Ma H, Cao SK (2018) Hydroxyapatite/mesoporous silica coated gold nanorods with improved degradability as a multi-responsive drug delivery platform. Mater Sci Eng C 83:90–98CrossRefGoogle Scholar
  23. 23.
    Baek S, Singh RK, Kim TH, Seo JW, Shin US, Chrzanowski W, Kim HW (2016) Triple hit with drug carriers: pH- and temperature-responsive theranostics for multimodal chemo- and photothermal therapy and diagnostic applications. ACS Appl Mater Interfaces 8:8967–8979CrossRefGoogle Scholar
  24. 24.
    Chen X, Soeriyadi AH, Lu X, Sagnella SM, Kavallaris M, Gooding JJ (2014) Dual bioresponsive mesoporous silica nanocarrier as an “AND” logic gate for targeted drug delivery cancer cells. Adv Funct Mater 24:6999–7006CrossRefGoogle Scholar
  25. 25.
    Song ZX, Shi J, Zhang Z, Qi ZE, Han SR, Cao SK (2018) Mesoporous silica-coated gold nanorods with thermally responsive polymeric cap for near infrared-activated drug delivery. J Mater Sci 53:7165–7179CrossRefGoogle Scholar
  26. 26.
    Zhu CL, Lu CH, Song XY, Yang HH, Wang XR (2011) Bioresponsive controlled release using mesoporous silica nanoparticles capped with aptamer-based molecular gate. J Am Chem Soc 133:1278–1281CrossRefGoogle Scholar
  27. 27.
    Sobot D, Mura S, Yesylevskyy SO, Dalbin L, Cayre F, Bort G, Mougin J, Desmaële D, Lepetre-Mouelhi S, Pieters G, Andreiuk B, Klymchenko AS, Paul JL, Ramseyer C, Couvreur P (2017) Conjugation of squalene to gemcitabine as unique approach exploiting endogenous lipoproteins for drug delivery. Nat Commun 8:1–9CrossRefGoogle Scholar
  28. 28.
    Murugadoss A, Khan A, Chattopadhyay A (2010) Stabilizer specific interaction of gold nanoparticles with a thermosensitive polymer hydrogel. J Nano Res 12:1331–1348CrossRefGoogle Scholar
  29. 29.
    Wu WT, Zhou T, Berliner A, Banerjee P, Zhou SQ (2010) Smart core-shell hybrid nanogels with Ag nanoparticle core for cancer cell imaging and gel shell for pH-regulated drug delivery. Chem Mater 22:1966–1976CrossRefGoogle Scholar
  30. 30.
    Gorelikov I, Field LM, Kumacheva E (2004) Hybrid microgels photoresponsive in the near-infrared spectral range. J Am Chem Soc 126:15938–15939CrossRefGoogle Scholar
  31. 31.
    Shi J, Liu XP, Sun XM, Cao SK (2011) Hybrid alginate beads with thermal-responsive gates for smart drug delivery. Polym Adv Technol 22:1539–1546CrossRefGoogle Scholar
  32. 32.
    Karg M, Lu Y, Carbó-Argibay E, Pastoriza-Santos I, Pe’rez-Juste J, Liz-Marza’n LM, Hellweg T (2009) Multiresponsive hybrid colloids based on gold nanorods and poly (NIPAM-co-allylacetic acid) microgels: tempreature- and pH-tunable plasmon resonance. Langmuir 25:3163–3167CrossRefGoogle Scholar
  33. 33.
    Kawano T, Niidome Y, Mori T, Katayama Y, Niidome T (2009) PNIPAM gel-coated gold nanorods for targeted delivery responding to a near-infrared laser. Bioconjug Chem 20:209–212CrossRefGoogle Scholar
  34. 34.
    Klinger D, Landfester K (2012) Stimuli-responsive microgels for the loading and release of functional compounds: fundamental concepts and applications. Polymer 53:5209–5231CrossRefGoogle Scholar
  35. 35.
    Hu L, Sarker AK, Islam MR (2013) Poly(N-isopropylacrylamide) microgel-based assemblies. J Polym Sci A Polym Chem 51:3004–3020CrossRefGoogle Scholar
  36. 36.
    Kim JH, Lee TR (2004) Thermo- and pH-responsive hydrogel-coated gold nanoparticles. Chem Mater 16:3647–3651CrossRefGoogle Scholar
  37. 37.
    Kudaibergenov S, Koetz J, Nuraje N (2018) Nanostructured hydrophobic polyampholytes: self-assembly, stimuli-sensitivity, and application. Adv Compos Hybrid Mater 1:1–36CrossRefGoogle Scholar
  38. 38.
    Nikoobakht B, El-Sayed MA (2003) Preparation and growth mechanism of gold nanorods (NRs) using seed-mediated growth method. Chem Mater 15:1957–1962CrossRefGoogle Scholar
  39. 39.
    Xu SH, Shi J, Feng DS, Yang L, Cao SK (2014) Hollow hierarchical hydroxyapatite/Au/polyelectrolyte hybrid microparticles for multi-responsive drug delivery. J Mater Chem B 2:6500–6507CrossRefGoogle Scholar
  40. 40.
    Hu M, Chen JY, Li ZY, Au L, Hartland GV, Li XD, Marqueze M, Xia Y (2007) Gold nanostructures: engineering their plasmonic properties for biomedical applications. Chem Soc Rev 38:1084–1094Google Scholar
  41. 41.
    Alkilany AM, Thompson LB, Boulos SP, Sisco PN, Murphy CJ (2012) Gold nanorods: their potential for photothermal therapeutics and drug delivery, tempered by the complexity of their biological interactions. Adv Drug Deliv Rev 64:190–199CrossRefGoogle Scholar
  42. 42.
    Zhang PH, He ZM, Wang C, Chen JN, Zhao JJ, Zhu XN, Li CZ, Min QH, Zhu JJ (2015) In situ amplification of intracellular microRNA with MNAzyme nanodevices for multiplexed imaging, logic operation, and controlled drug release. ACS Nano 9(1):789–798CrossRefGoogle Scholar
  43. 43.
    Sato T, Hirono J, Tonoike M (1994) Tuning specificities to aliphatic odorants in mouse olfactory receptor neurons and their local distribution. J Neurophysiol 72(6):2980–2989CrossRefGoogle Scholar
  44. 44.
    Huang P, Zeng B, Mai Z, Deng JT, Fang YP, Huang WH, Zhang HW, Yuan JY, Wei Y, Zhou WY (2015) Novel drug delivery nanosystems based on out-inside bifunctionalized mesoporous silica yolk-shell magnetic nanostars used as nanocarriers for curcumin. J Mater Chem B 4:46–56CrossRefGoogle Scholar
  45. 45.
    Monem AS, Elbialy N, Mohamed N (2014) Mesoporous silica coated gold nanorods loaded doxorubicin for combined chemo-photothermal therapy. Int J Pharm 470:1–7CrossRefGoogle Scholar
  46. 46.
    Wang LM, Jiang XM, Ji YL, Bai R, Zhao YL, Wu XC, Chen CY (2013) Surface chemistry of gold nanorods: origin of cell membrane damage and cytotoxicity. Nanoscale 5:8384–8391CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.School of Materials Science and EngineeringZhengzhou UniversityZhengzhouChina
  2. 2.People’s Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhouChina

Personalised recommendations