Acidophil stem cell pituitary adenoma: a case report and literature review
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In this article, we describe a very rare case of pituitary acidophilic stem cell adenoma, accompanied by a literature review. We present the case of 33-year-old woman with a history of amenorrhea, galactorrhea, elevated prolactin levels, and pituitary tumor. Despite suppression of prolactin levels with cabergoline, the pituitary tumor continued to increase in size and the patient developed clinical symptoms and biochemistry consistent with the diagnosis of acromegaly due to acidophilic stem cell adenoma, an extremely rare subtype of mixed growth hormone/prolactin adenoma, which behaves more aggressively and has a lower surgical cure rate compared to the pure GH-secreting adenoma. The patient had in vitro fertilization 2 years after the successful pituitary surgery and delivered healthy twins. To our knowledge, this is the only case report which describes acromegaly developing during cabergoline treatment. This case also highlights the importance of having a correct histopathological diagnosis to determine the behavior of the tumor and decide on further management.
KeywordsAcidophilic Pituitary adenoma Acromegaly Pituitary stem cell adenoma
In vitro fertilization
Insulin growth factor 1
Oral glucose tolerance test
Magnetic resonance imaging
Follicular stimulating hormone
Serum hormone-binding globulin
Adrenocorticotrophic stimulating hormone
Acute medical admission unit
Both Anupriya Annapurni and Manjusha Rathi contributed to the planning of the manuscript, the review of the literature, and the writing and review of the original and final manuscript.
Compliance with ethical standards
Conflict of interest
The authors declare that they have no potential conflicts of interest.
Statement of informed consent
Informed consent has been obtained from the patient for publication of the case report and accompanying images.
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