, Volume 18, Issue 1, pp 99–102 | Cite as

Adiponectin and vitamin D-binding protein concentrations are independently associated in apparently healthy women but not men: a validation cohort

  • Spyridon N. KarrasEmail author
  • Stergios Α. Polyzos
  • Xanthippi Tsekmekidou
  • Spyridon Gerou
  • Elpida Gavana
  • Vasileios Papageorgiou
  • Kalliopi Kotsa
Original Article


Vitamin D-binding protein (VDBP) is one of the key factors regulating vitamin D homeostasis [1, 2]. Adiponectin is secreted mainly from visceral adipose tissue and affects energy homeostasis [3]. A possible interaction between vitamin D and adiponectin [4], especially in profound hypovitaminosis D, has been reported. Adipokine profile at birth has been associated with fat mass in late childhood [5].

We recently reported an independent positive association between VDBP and adiponectin in both mothers and neonates at birth [6]. This independent association raised a hypothesis regarding a potential role of VDBP as a regulator of biological activity of adiponectin. However, as VDBP concentrations are known to increase in pregnancy [1], our observation could be limited only to pregnancy.

The aim of this study was to validate the association between adiponectin and VDBP levels in apparently healthy men and women.

Patients and methods

Study population

This was a cross-sectional...


Adiponectin Vitamin D Vitamin D-binding protein 


Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

Aristotle University Ethical committee approval obtained.


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Copyright information

© Hellenic Endocrine Society 2018

Authors and Affiliations

  • Spyridon N. Karras
    • 1
    Email author
  • Stergios Α. Polyzos
    • 2
  • Xanthippi Tsekmekidou
    • 1
  • Spyridon Gerou
    • 3
  • Elpida Gavana
    • 3
  • Vasileios Papageorgiou
    • 4
  • Kalliopi Kotsa
    • 1
  1. 1.Division of Endocrinology and Metabolism, First Department of Internal Medicine, Medical SchoolAristotle University of Thessaloniki, AHEPA HospitalThessalonikiGreece
  2. 2.First Department of Pharmacology, Medical SchoolAristotle University of ThessalonikiThessalonikiGreece
  3. 3.Laboratories “Analysis”ThessalonikiGreece
  4. 4.Laboratories PapageorgiouNea MoudaniaGreece

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