, Volume 18, Issue 1, pp 65–70 | Cite as

Asymptomatic and normocalcemic hyperparathyroidism, the silent attack: a combo-endocrinology overview

  • Dimitrios A. Anastasilakis
  • Polyzois Makras
  • Stergios A. Polyzos
  • Athanasios D. AnastasilakisEmail author
  • Part of the COMBO ENDO TEAM: 2017
Review Article


Asymptomatic primary hyperparathyroidism (PHPT) and the new variant of PHPT, normocalcemic PHPT, are considered by many physicians as mild, innocuous forms of disease, requiring nothing more than monitoring. Although this may be true in some cases in which the disease does not progress or cause complications, deterioration with more or less severe manifestations may occur. In the present review, we discuss the existing evidence of both the classic (skeletal and renal) and non-classic (cardiovascular, gastrointestinal, and psychiatric) features that have been attributed to asymptomatic and normocalcemic PHPT and the treatment effect on them.


Asymptomatic Bone Hyperparathyroidism Normocalcemic Renal 


Compliance with ethical standards

The authors declare that they have no conflict of interest.


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Copyright information

© Hellenic Endocrine Society 2018

Authors and Affiliations

  1. 1.Medical SchoolAristotle University of ThessalonikiThessalonikiGreece
  2. 2.Department of Endocrinology & Diabetes251 Hellenic Air Force & VA General HospitalAthensGreece
  3. 3.First Department of Pharmacology, Medical SchoolAristotle University of ThessalonikiThessalonikiGreece
  4. 4.Department of Endocrinology & Metabolism424 General Military HospitalN. Efkarpia, ThessalonikiGreece

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