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Hormones

, Volume 18, Issue 1, pp 3–5 | Cite as

Replenishment of vitamin D status: theoretical and practical considerations

  • Salvatore MinisolaEmail author
  • Jessica Pepe
  • Pietro Donato
  • Evelina Vigna
  • Marco Occhiuto
  • Federica Ferrone
  • Federica Biamonte
  • Veronica Cecchetti
  • Vittoria Carmela Danese
  • Chiara Sonato
  • Piergianni BIondi
  • Luciano Colangelo
  • Cristiana Cipriani
Expert Opinion

In recent years, there have been a very large number of scientific publications concerning various aspects of vitamin D, ranging from physiologic to therapeutic studies. However, despite the multiple discoveries made in this fast-growing scientific research area, numerous issues still remain unresolved [1, 2]. Examples include, though are not limited to, the definition of hypovitaminosis D (this term is used to cover cases of both insufficiency and deficiency), i.e. 20 vs 30 ng/mL; the relationship between 25(OH)D and parathyroid hormone (PTH) (linear vs non-linear and related point of inflection) [3, 4, 5]; the referent that should be considered (total vs free determination) [6]; and the utility of screening for hypovitaminosis vs universal supplementation [7].

However, one of the most heatedly debated issues is the question of what comprises appropriate treatment. Indeed, irrespective of the threshold adopted, there is uncertainty regarding the specific vitamin and the dose that...

Keywords

Vitamin D Prevention Treatment Toxicity 

Notes

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

References

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Copyright information

© Hellenic Endocrine Society 2018

Authors and Affiliations

  • Salvatore Minisola
    • 1
    Email author
  • Jessica Pepe
    • 1
  • Pietro Donato
    • 1
  • Evelina Vigna
    • 1
  • Marco Occhiuto
    • 1
  • Federica Ferrone
    • 1
  • Federica Biamonte
    • 1
  • Veronica Cecchetti
    • 1
  • Vittoria Carmela Danese
    • 1
  • Chiara Sonato
    • 1
  • Piergianni BIondi
    • 1
  • Luciano Colangelo
    • 1
  • Cristiana Cipriani
    • 1
  1. 1.Department of Internal Medicine and Medical Disciplines“Sapienza”, Rome UniversityRomeItaly

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