, Volume 18, Issue 1, pp 55–63 | Cite as

Hypoparathyroidism: is it that easy to treat?

  • Evangelia Triantafyllou
  • Maria P. Yavropoulou
  • Athanasios D. Anastasilakis
  • Polyzois MakrasEmail author
Review Article


Hypoparathyroidism is a relatively rare endocrine disease characterised by either null or inappropriately low secretion of parathyroid hormone (PTH) for serum calcium levels. The other main laboratory findings include hypocalcaemia, inappropriately normal or high urine calcium excretion and hyperphosphataemia with low urine phosphate excretion. The management of hypoparathyroidism should be tailored to each individual case, which makes it a demanding undertaking in everyday clinical practice. In this review, we sought to focus on the diagnostic approach of hypoparathyroidism and the therapeutic challenges of the disease from a clinical perspective. Conventional treatment with vitamin D analogues and calcium salts is no longer the only available treatment, since replacement treatment with PTH(1-84) has recently been approved for the disease. However, the optimal treatment schedule is yet to be defined.


Hypoparathyroidism Calcium PTH1-34 PTH1-84 


Compliance with ethical standards

Conflict of interest

All authors have nothing to declare regarding this paper.


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Copyright information

© Hellenic Endocrine Society 2018

Authors and Affiliations

  • Evangelia Triantafyllou
    • 1
  • Maria P. Yavropoulou
    • 1
  • Athanasios D. Anastasilakis
    • 2
  • Polyzois Makras
    • 3
    Email author
  1. 1.Division of Endocrinology and Metabolism, 1st Department of Internal Medicine, AHEPA University HospitalAristotle University of ThessalonikiThessalonikiGreece
  2. 2.Department of Endocrinology424 General Military HospitalThessalonikiGreece
  3. 3.Department of Endocrinology and Diabetes251 Hellenic Air Force & VA General HospitalAthensGreece

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