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Functional hypothalamic amenorrhea: case presentations and overview of literature

Teaching Case Presentations


Functional hypothalamic amenorrhea is a form of chronic anovulation not due to identifiable organic causes with adverse health consequences. A thorough history is paramount in the identification of women with this disorder as it is usually associated with lifestyle factors such as stress, weight loss, and excessive exercise. In this paper, recently published clinical guidelines are reviewed and a series of cases is presented that highlights diagnostic and therapeutic challenges encountered.


Amenorrhea Anorexia nervosa Excessive exercise Stress Energy deficit Hypercortisolemia 


Compliance with ethical standards

Conflict of interest

The author declares that she has no conflict of interest.


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Copyright information

© Hellenic Endocrine Society 2018

Authors and Affiliations

  1. 1.Department of Internal Medicine-Endocrine DivisionMcGovern Medical SchoolHoustonUSA

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