European Geriatric Medicine

, Volume 10, Issue 6, pp 905–911 | Cite as

Plasma inflammatory factors in older people predict acute kidney injury: a case–control study

  • Li Han
  • Rong-rong Ren
  • Kai-Lan Wan
  • Ling YangEmail author
  • Jian-qiang KangEmail author
Research Paper

Key summary points


To investigate whether inflammatory factors are predictors of acute kidney injury (AKI) in older people in the intensive care unit (ICU).


Plasma inflammatory contents of IL-6 and IL-8 can predict AKI in older people. Management of inflammatory factors should take into consideration the age of AKI patients.


Plasma inflammatory factors in older people predict acute kidney injury.



To investigate whether inflammatory factors are predictors of acute kidney injury (AKI) in older people in the intensive care unit (ICU).


We performed a case–control study that included 98 older people (≥ 65 years) who were admitted to ICU from 2013 to 2017. The contents of plasma pro-inflammatory factors [interleukin (IL)-1b, IL-6, IL-8, tumor necrosis factor-a (TNF-α)] and the anti-inflammatory factor IL-10 were determined at the first day of admission. Patients were assessed based on the Kidney Disease Improving Global Outcomes (KDIGO) criteria and were divided into AKI and non-AKI (control) groups (n = 49 for each). T test was applied for differences comparisons in the levels of inflammatory factors between the two groups. Logistic regression was used to identify independent predictors of AKI.


AKI patients had significantly elevated plasma contents of IL-6, IL-8 and IL-10, relative to the control group. A strong correlation was observed between IL-6 and IL-8 with AKI (OR 36.4 and 18.2, respectively). For each increase in the natural log unit in the levels of IL-6 and IL-8, the risk of developing AKI augmented by 36.4% and 18.2%, respectively. Moreover, the higher the tertile value of IL-6 and IL-8, the higher the risk of developing AKI. The area under the receiver operating characteristic curve for IL-6 and IL-8 was, respectively, 87% and 83% for predicting AKI.


Plasma inflammatory contents of IL-6 and IL-8 can predict AKI in older people. Management of inflammatory factors should take into consideration the age of AKI patients.


Inflammatory factors Acute kidney injury Older people Intensive care unit 



The current study was funded by the National Natural Science Foundation of China (No. 81200017), the Foundation of Traditional Chinese and Western Medicine of General Hospitals in Shanghai (No. ZHYY-ZXYJHZX-2-201701) and the Foundation of Subject of Shanghai science and technology committee (18441905200).

Compliance with ethical standards

Conflict of interest

The authors declare no conflicts of interest.

Ethical approval

The study was approved by Shanghai Jiaotong University Xinhua Hospital Ethics Committee (XHEC2011-002) and in accordance with the Declaration of Helsinki.

Informed consent

This was an observational study and all laboratory indices observed were commonly measured for all patients during the stay, the need for written informed consent was waived by the ethical review board.


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Copyright information

© European Geriatric Medicine Society 2019

Authors and Affiliations

  1. 1.Department of Gerontology, Xinhua HospitalShanghai Jiaotong UniversityShanghaiChina
  2. 2.Department of Anesthesiology and Surgical Intensive Care Unit, Xinhua HospitalShanghai Jiaotong UniversityShanghaiChina
  3. 3.School of Data ScienceFudan UniversityShanghaiChina

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