European cohorts of older HIV adults: POPPY, AGEhIV, GEPPO, COBRA and FUNCFRAIL

  • Jovana Milic
  • Magdalena Russwurm
  • Ana Cerezales Calvino
  • Fátima Brañas
  • Matilde Sánchez-Conde
  • Giovanni GuaraldiEmail author
Special Article

Key summary points


The aim of this paper is to describe ongoing aging HIV cohorts that include older (> 50 years) or geriatric (> 65 years) people living with HIV and present the key results obtained in those studies.


Existing aging HIV cohorts are pointing out unmet medical needs of OALWH. However, there are no studies designed to detect best ART strategies in this population and various outcomes that go beyond the viro-immunological success, such as frailty, geriatric syndromes, physical function, disability, quality of life and healthy aging are still not routinely part of aging cohorts.


The already present demographic transition affecting PLWH are not paralleled by significant changes in the clinical management. In order to better describe aging trajectories in this population, it is essential to collect and measure immunological biomarkers. Results from aging HIV observational studies can also inspire randomized clinical trials.



The recent and rapid demographic changes affecting people living with HIV (PLWH) produced a subset of older adults demanding a prompt response both in clinical practice and research setting. The scientific community had to properly design studies that include older adults living with HIV (OALWH), aged > 50 years, or geriatric PLWH, aged > 65 years to explore the interaction between aging and HIV itself, antiretroviral therapy (ART) and non-infectious co-morbidities (NICM). Choosing between these two types of cohorts may represent a trap, but also a possibility to measure different outcomes and obtain different evidence. The aim of this paper is to describe ongoing aging HIV cohorts that include older or geriatric PLWH and present the key results obtained in those studies.


So far, in Europe, there are ongoing cohorts that comprise OALWH or geriatric PLWH: AGEhIV, POPPY, GEPPO, FUNCFRAIL and COBRA. We will summarize crucial findings from each study published up to now, which will be categorized as results related to HIV and ART, NICM and geriatric syndromes.


Existing aging HIV cohorts are pointing out unmet medical needs of OALWH but are still not representative of the entire European HIV aging epidemic. Moreover, there are no studies designed to detect best ART strategies in this population and various outcomes that go beyond the viro-immunological success are still not routinely part of aging cohorts.


Results from aging cohorts with outcomes that go beyond the undetectability will pave the way to health care providers to encounter unmet needs of OALWH.


Observational HIV study Aging Older adults Geriatric people living with HIV 



There was no dedicated funding for this study.

Compliance with ethical standards

Conflict of interest

GG is an investigator in GEPPO cohort and a collaborator in COBRA cohort. FB and MSC are investigators in FUNCFRAIL cohort. All other authors report no conflicts of interest.

Ethical approval

This article does not contain any studies with human participants performed by any of the authors.

Informed consent

For this type of study formal consent is not required.


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Copyright information

© European Geriatric Medicine Society 2019

Authors and Affiliations

  • Jovana Milic
    • 1
    • 2
  • Magdalena Russwurm
    • 3
  • Ana Cerezales Calvino
    • 4
  • Fátima Brañas
    • 5
  • Matilde Sánchez-Conde
    • 6
  • Giovanni Guaraldi
    • 1
    Email author
  1. 1.Modena HIV Metabolic Clinic, Infectious Diseases Unit, School of MedicineUniversity of Modena and Reggio EmiliaModenaItaly
  2. 2.Clinical and Experimental Medicine PhD ProgramUniversity of Modena and Reggio EmiliaModenaItaly
  3. 3.Medical University of ViennaViennaAustria
  4. 4.University Hospital of A Coruña (CHUAC)La CorunaSpain
  5. 5.Geriatrics DepartmentHospital Universitario Infanta LeonorMadridSpain
  6. 6.Infectious Diseases DepartmentHospital Universitario Ramón y Cajal, IRYCISMadridSpain

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