Association between allopurinol use and Parkinson’s disease in older adults
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Little evidence is available about the association between allopurinol use and Parkinson’s disease. The present study aimed to explore the association between allopurinol use and Parkinson’s disease in older adults in Taiwan.
We conducted a population-based case–control study using the database of the Taiwan National Health Insurance Program. In total, 4399 subjects aged ≥ 65 years with newly diagnosed Parkinson’s disease between 2000 and 2013 were included as the cases. Additionally, 4399 subjects aged ≥ 65 years without Parkinson’s disease were randomly selected as the controls. Both cases and controls were matched for age and comorbidities. Ever use of allopurinol was defined as subjects who had at least a prescription for allopurinol before the index date, whereas never use of allopurinol was defined as those who never had a prescription for allopurinol before the index date. We used the logistic regression model to calculate the odds ratio (OR) and 95% confidence interval (CI) for the association between allopurinol use and Parkinson’s disease.
The OR of Parkinson’s disease was 0.93 for subjects with ever use of allopurinol (95% CI 0.82, 1.04), compared with never use.
No association can be detected between allopurinol use and Parkinson’s disease in older adults in Taiwan.
KeywordsAllopurinol Case–control study Older adults Parkinson’s disease Taiwan National Health Insurance Program
This study was supported in part by the Ministry of Health and Welfare, Taiwan (MOHW107-TDU-B-212-123004), China Medical University Hospital, Academia Sinica Stroke Biosignature Project (BM10701010021), MOST Clinical Trial Consortium for Stroke (MOST 106-2321-B-039-005-), Tseng-Lien Lin Foundation, Taichung, Taiwan, and Katsuzo and Kiyo Aoshima Memorial Funds, Japan. These funding agencies did not influence the study design, data collection and analysis, decision to publish, or preparation of the manuscript.
S-WL: contributed to the conception of the article, initiated the draft of the article, and revised the article. C-LL: conducted the data analysis and revised the article. K-FL: participated in the data interpretation and revised the article.
Compliance with ethical standards
Conflict of interest
The authors disclose no conflicts of interest.
The study was approved by the Research Ethics Committee of China Medical University and Hospital in Taiwan (CMUH-104-REC2-115).
Patient informed consent was not required. Insurance reimbursement claims data used in the study were available for public access. Patient identification numbers had been scrambled to ensure confidentiality.
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