Journal of Flow Chemistry

, Volume 9, Issue 1, pp 35–42 | Cite as

Multi-step continuous flow synthesis of fluconazole

  • Judy Szeto
  • Vi-Anh Vu
  • Jeremiah P. Malerich
  • Nathan CollinsEmail author
Full Paper


The development of a flow chemistry approach to the anti-fungal fluconazole is described. A continuous, two-reactor, three-step synthesis of fluconazole from 2-chloro-2′,4′-difluoroacetophenone was achieved with no intermediate purification. The synthesis has been successfully demonstrated on a Vapourtec commercial flow chemistry system.

Graphical abstract


Fluconazole Corey-Chaykovsky epoxidation 1,2,4-triazole Friedel-crafts acylation Vapourtec 



This research was developed with funding from the Defense Advanced Research Projects Agency (DARPA, W911NF-16-C-0051). The views, opinions, and/or findings expressed are those of the author(s) and should not be interpreted as representing the official views or policies of the Department of Defense or the U.S. Government.


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Copyright information

© Akadémiai Kiadó 2018

Authors and Affiliations

  • Judy Szeto
    • 1
  • Vi-Anh Vu
    • 1
  • Jeremiah P. Malerich
    • 1
  • Nathan Collins
    • 1
    Email author
  1. 1.Biosciences DivisionSRI InternationalMenlo ParkUSA

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