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Journal of Flow Chemistry

, Volume 8, Issue 3–4, pp 129–138 | Cite as

Continuous preparation for rifampicin

  • Xin Li
  • Zhuang Liu
  • Hao Qi
  • Zheng Fang
  • Siyu Huang
  • Shanshan Miao
  • Kai Guo
Full Paper
  • 47 Downloads

Abstract

To reduce the cost and improve the efficiency for rifampicin preparation, a continuous flow synthesis of rifampicin starting from rifamycin S and tert-butylamine was studied in a microreactor. Two reaction steps and one purification step were coupled in a microreactor, and rifampicin was obtained with 67% overall yield. This method used 25% less 1-amino-4-methyl piperazine and got 16% higher overall yield without changing solvent and purification process between steps. This method has a good potential for further industrial application.

Keywords

Continuous flow synthesis Coupling of reaction and separation Rifampicin preparation 

Notes

Acknowledgements

Authors acknowledges the funding from The jiangsu synergetic innovation center for advanced bio-manufacture (XTE1852), The National Key Research and Development Program of China (2016YFB0301501), National Natural Science Foundation of China (21522604), National Natural Science Foundation of China (U1463201), The National Natural Science Foundation of China (21776130), The jiangsu synergetic innovation center for advanced bio-manufacture (XTE1821), The jiangsu synergetic innovation center for advanced bio-manufacture (XTE1802).

Supplementary material

41981_2018_17_MOESM1_ESM.docx (314 kb)
ESM 1 (DOCX 313 kb)

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Copyright information

© Akadémiai Kiadó 2018

Authors and Affiliations

  1. 1.College of Biotechnology and Pharmaceutical EngineeringNanjing Tech UniversityNanjingChina
  2. 2.State Key Laboratory of Materials-Oriented Chemical EngineeringNanjing Tech UniversityNanjingChina

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