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Innovative Child-Resistant Packaging for Pharmaceutical Solid Dosage Forms

  • Lalji BaldaniyaEmail author
  • Vaibhav Shah
  • Malav Maniar
  • Mukesh Gohel
  • Vaishali Thakkar
  • Tejal Gandhi
Research Article
  • 8 Downloads

Abstract

The major oral solid medicines are sold in blister and strips packaging, which are packaged in a carton box. Children, who manage to open such boxes, while unsupervised, are in great danger of being poisoned by swallowing the contents. A CRP usually requires a special trick to open it. The aim was to design and validate the performance of innovative CRP system with unique features. Materials used were the plastic grade, click lock system, and blister pack. The test conducted on test panels of 100 healthy children between 42 and 51 months were asked to open a pack. Each panel divided into 3 groups, viz. 30 children of 42–44 months, 40 children 45–48 months, and 30 children 49–51 months. The panel of 100 healthy adults divided into 3 groups, viz. 25 adults 18–40 years, 25 adults 40–59 years, and 50 adults 60–70 years. Results shown only 6% of children succeeded to open CRP, while 94% failed to open CRP within 5 min. In the case of adults, 96% succeeded to open CRP without imposing any difficulties. There was a successful development of a prototype of CRP, which can used for the packaging of pharmaceutical products. CRP deprived children to have access of medicated packaging system, which resulted in devoid of any poisonous effect to the children.

Keywords

Child-resistant packaging (CRP) Strip packaging Re-closable packaging 

Notes

Acknowledgements

Authors are very much thankful to Anand Pharmacy College for technical assistance and extending facility for successful execution of this project. Thankful to Student Start-up and Innovation Policy for sponsoring the research work. In addition, thank all the volunteers who participated and facilitated the survey part of this study.

Supplementary material

41783_2019_72_MOESM1_ESM.docx (272 kb)
Supplementary material 1 (DOCX 272 kb)
41783_2019_72_MOESM2_ESM.pdf (473 kb)
Supplementary material 2 (PDF 473 kb)
41783_2019_72_MOESM3_ESM.pdf (455 kb)
Supplementary material 3 (PDF 455 kb)

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Copyright information

© Indian Institute of Packaging 2019

Authors and Affiliations

  1. 1.Department of Pharmaceutics, Faculty of PharmacyMarwadi UniversityRajkotIndia
  2. 2.Department of PharmaceuticsAnand Pharmacy CollegeAnandIndia

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