Sleep and Vigilance

, Volume 1, Issue 1, pp 47–48 | Cite as

The SAVE Trial: Has the Importance of CPAP for Preventing Cardiovascular Events been Discounted?

  • Ahmed S. BahammamEmail author
  • Seithikurippu R. Pandi-PerumalEmail author
  • David Warren Spence
  • Adam Moscovitch
  • David L. Streiner

A paper by McEvoy et al. recently appeared in the New England Journal of Medicine concerning the role of continuous positive airway pressure (CPAP) in the prevention of cardiovascular events in patients with obstructive sleep apnea (OSA) [1]. The primary composite end point of the study was death from cardiovascular causes, myocardial infarction, stroke, or hospitalization for unstable angina, heart failure, or transient ischemic attack. The results of this paper, apparently showing that CPAP had no protective effect against various forms of cardiovascular disease (CVD), came as a surprise to us in light of the accumulated evidence linking OSA with CVD. The currently available data from randomized controlled trials (RCTs) have shown that CPAP has beneficial effects on factors associated with CVD such as blood pressure, increased sympathetic activity, endothelial function, and insulin sensitivity [2, 3]. In addition, several observational studies have shown that CPAP use reduces the...


Obstructive Sleep Apnea Continuous Positive Airway Pressure Obstructive Sleep Apnea Patient Severe Obstructive Sleep Apnea Oxygen Desaturation Index 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media Singapore 2017

Authors and Affiliations

  1. 1.Department of Medicine, College of Medicine, The University Sleep Disorders CenterKing Saud UniversityRiyadhSaudi Arabia
  2. 2.Somnogen Canada Inc.TorontoCanada
  3. 3.TorontoCanada
  4. 4.Sleep and Fatigue InstituteThe University of CalgaryCalgaryCanada
  5. 5.Department of Psychiatry and Behavioral NeurosciencesMcMaster UniversityHamiltonCanada
  6. 6.Department of PsychiatryUniversity of TorontoTorontoCanada

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