The SAVE Trial: Has the Importance of CPAP for Preventing Cardiovascular Events been Discounted?
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A paper by McEvoy et al. recently appeared in the New England Journal of Medicine concerning the role of continuous positive airway pressure (CPAP) in the prevention of cardiovascular events in patients with obstructive sleep apnea (OSA) . The primary composite end point of the study was death from cardiovascular causes, myocardial infarction, stroke, or hospitalization for unstable angina, heart failure, or transient ischemic attack. The results of this paper, apparently showing that CPAP had no protective effect against various forms of cardiovascular disease (CVD), came as a surprise to us in light of the accumulated evidence linking OSA with CVD. The currently available data from randomized controlled trials (RCTs) have shown that CPAP has beneficial effects on factors associated with CVD such as blood pressure, increased sympathetic activity, endothelial function, and insulin sensitivity [2, 3]. In addition, several observational studies have shown that CPAP use reduces the...
KeywordsObstructive Sleep Apnea Continuous Positive Airway Pressure Obstructive Sleep Apnea Patient Severe Obstructive Sleep Apnea Oxygen Desaturation Index
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