Developments of 3D polycaprolactone/beta-tricalcium phosphate/collagen scaffolds for hard tissue engineering
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3D bioprinting provides an innovative strategy to fabricate a new composite scaffold material consisted in a porous and rough structure with using polycaprolactone (PCL), beta-tricalcium phosphate (β-TCP), and collagen as a building block for tissue engineering. We investigated the optimization of the scaffold properties based on the β-TCP concentration using 3D bioprinting method. Computer-aided drawing was applied in order to digitally design the scaffolds while instead of solid filaments, materials were prepared as a blend solution and controlled evaporation of the solvent during the bioprinting was enabled the proper solidification of the scaffolds, and they were successfully produced with well-defined porous structure. This work demonstrated the feasibility of complex PCL/β-TCP/collagen scaffolds as an alternative in the 3D bioprinting engineering to the fabrication of porous scaffolds for tissue engineering.
KeywordsBiomaterials Biomedical engineering Additive manufacturing Hard tissue scaffolds
This study has been founded by BAPKO, Marmara University, grant no. FEN-C-YLP-090217-0066.
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Conflict of interest
The authors declare that they have no conflict of interest.
- 11.Lee, V.K., Dias, A., Ozturk, M.S., Chen, K., Tricomi, B., Corr, D.T., Intes, X., Dai, G.: 3D Bioprinting and 3D Imaging for Stem Cell Engineering, pp. 33–66. Springer International Publishing (2015)Google Scholar
- 14.Rosales-Leal, J.I., Rodríguez-Valverde, M.A., Mazzaglia, G., Ramón-Torregrosa, P.J., Rodriguez, L.D., Martinez, O.G., Vallecillo-Capilla, M., Ruiz, C., Cabrerizo-Vílchez, M.A.: Effects of roughness, wettability and morphology of engineered titanium surfaces on osteoblast-like cell adhesion. Colloids Surf. A Physicochem. Eng. Asp. 365(1–3), 222–229 (2010)CrossRefGoogle Scholar
- 17.Khan, S.N., Warkhedkar, R.M., Shyam, A.K.: Human bone strength evaluation through different mechanical tests. IJCET. 2, 2347–5161 (2014)Google Scholar
- 19.Aydogdu, M.O., Chou, J., Altun, E., Ekren, N., Cakmak, S., Eroglu, M., Osman, A.A., Kutlu, O., Oner, E.T., Avsar, G., Oktar, F.N., Yilmaz, I., Gunduz, O.: Int. J. Polym. Mater. Polym. Biomater. (2018). https://doi.org/10.1080/00914037.2018.1443930