Strategies for accurate response assessment of radiochromic film using flatbed scanner for beam quality assurance

  • Xu-Dong Zhang
  • Yuan-Hao Liu
  • Xiao-Bin TangEmail author
  • Ming-Chen Hsiao
  • Wei-Lin Chen
  • Chang-Ran Geng
  • Wen-Cheng Shao
  • Chun-Hui Gong
  • Silva Bortolussi
  • Di-Yun Shu


Radiochromic film is a useful tool for beam quality assurance, but accurate response assessment of the film is still a problem. In this study, the response uncertainties of HDV2 film were investigated using a flatbed scanner from both the scanning settings and interscan variability. Scanning settings are fixed conditions for scanning, including scanning resolution and focus setting. In this study, multipeak distributions of pixel values were found under some dots-per-inch values, which should be avoided, and the optimal setting of 2000 dpi without this problem was selected. By changing the focus setting, the relative standard deviation of pixel values was reduced by 36–50%. The influence of the interscan variability induced by three factors was investigated, including the outside illumination intensity, film homogeneity, and operating temperature. Scanning the film before and after irradiation at the same position was recommended. Moreover, the suitable operating temperature range for the scanner was found to be 15–24 °C, which results in stable film responses. Regarding the studied factors, correction methods and strategies were proposed, and the accurate response assessment of HDV2 film was realized. Finally, a standard operating procedure for response assessment of films was introduced. It can help other researchers study more scanners, films, and particle types.


Radiochromic film Response assessment Scanning setting Interscan variability Standard operating procedure 

Supplementary material

41365_2019_685_MOESM1_ESM.docx (605 kb)
Supplementary material 1 (DOCX 605 kb)


  1. 1.
    B. Arjomandy, N. Sahoo, X. Ding et al., Use of a two-dimensional ionization chamber array for proton therapy beam quality assurance. Med. Phys. 35, 3889–3894 (2008). CrossRefGoogle Scholar
  2. 2.
    R. Chu, D. Lewis, K. O’Hara et al., GafchromicTM dosimetry media: a new high dose, thin film routine dosimeter and dose mapping tool. Int. J. Radiat. Appl. Instrum. Part C Radiat. Phys. Chem. 35, 767–773 (1990). CrossRefGoogle Scholar
  3. 3.
    W.L. McLaughlin, Y.-D. Chen, C.G. Soares et al., Sensitometry of the response of a new radiochromic film dosimeter to gamma radiation and electron beams. Nucl. Instrum. Meth. A 302, 165–176 (1991). CrossRefGoogle Scholar
  4. 4.
    C.G. Soares, Radiochromic film dosimetry. Radiat. Meas. 41, S100–S116 (2006). CrossRefGoogle Scholar
  5. 5.
    A. Rink, I.A. Vitkin, D.A. Jaffray, Energy dependence (75kVp to 18MV) of radiochromic films assessed using a real-time optical dosimeter. Med. Phys. 34, 458–463 (2007). CrossRefGoogle Scholar
  6. 6.
    Y. Yuri, K. Narumi, A. Chiba et al., Study on the coloration response of a radiochromic film to MeV cluster ion beams. Nucl. Instrum. Methods A. 872, 126–130 (2017). CrossRefGoogle Scholar
  7. 7.
    Y. Yuri, K. Narumi, T. Yuyama, Characterization of a Gafchromic film for the two-dimensional profile measurement of low-energy heavy-ion beams. Nucl. Instrum. Methods A 828, 15–21 (2016). CrossRefGoogle Scholar
  8. 8.
    D. Lewis, S. Devic, Correcting scan-to-scan response variability for a radiochromic film-based reference dosimetry system. Med. Phys. 42, 5692–5701 (2015). CrossRefGoogle Scholar
  9. 9.
    T. Yao, L.H. Luthjens, A. Gasparini et al., A study of four radiochromic films currently used for (2D) radiation dosimetry. Radiat. Phys. Chem. 133, 37–44 (2017). CrossRefGoogle Scholar
  10. 10.
    S. Devic, Y.Z. Wang, N. Tomic et al., Sensitivity of linear CCD array based film scanners used for film dosimetry. Med. Phys. 33, 3993–3996 (2006). CrossRefGoogle Scholar
  11. 11.
    B.C. Ferreira, M.D.C. Lopes, M. Capel, Evaluation of an Epson flatbed scanner to read Gafchromic EBT films for radiation dosimetry. Phys. Med. Biol. 54, 1073–1085 (2009). CrossRefGoogle Scholar
  12. 12.
    J. Desroches, H. Bouchard, F. Lacroix, Potential errors in optical density measurements due to scanning side in EBT and EBT2 Gafchromic film dosimetry. Med. Phys. 37, 1565 (2010). CrossRefGoogle Scholar
  13. 13.
    D. Lewis, M.F. Chan, Correcting lateral response artifacts from flatbed scanners for radiochromic film dosimetry. Med. Phys. 42, 416–429 (2015). CrossRefGoogle Scholar
  14. 14.
    D. Lewis, A. Micke, X. Yu et al., An efficient protocol for radiochromic film dosimetry combining calibration and measurement in a single scan. Med. Phys. 39, 6339–6350 (2012). CrossRefGoogle Scholar
  15. 15.
    S. Devic, N. Tomic, D. Lewis, Reference radiochromic film dosimetry: review of technical aspects. Phys. Med. 32, 541–556 (2016). CrossRefGoogle Scholar
  16. 16.
    A. Aydarous, M. El Ghazaly Characterization of HD-V2 Gafchromic Film for Measurement of Spatial Dose Distribution from Alpha Particle of 5.5 MeV. World Academy of Science, Engineering and Technology, International Journal of Mathematical, Computational, Physical, Electrical and Computer Engineering. 7:1174-1176 (2013).
  17. 17.
    M.-C. Hsiao, Y.-H. Liu, W.-L. Chen et al., Neutron response of GafChromic® EBT2 film. Phys. Med. Biol. 58, 1391 (2013). CrossRefGoogle Scholar
  18. 18.
    A. Aydarous, A. Badawi, S. Abdallah, The effects of electrons and photons irradiation on the optical and thermophysical properties of Gafchromic HD-V2 films. Results Phys. 6, 952–956 (2016). CrossRefGoogle Scholar
  19. 19.
    S. Bartzsch, J. Lott, K. Welsch et al., Micrometer-resolved film dosimetry using a microscope in microbeam radiation therapy. Med. Phys. 42, 4069–4079 (2015). CrossRefGoogle Scholar
  20. 20.
    K.E. Spears, S.L.Webb. Optical image scanner with variable focus. 2005Google Scholar
  21. 21.
    S. Reinhardt, M. Hillbrand, J. Wilkens et al., Comparison of gafchromic EBT2 and EBT3 films for clinical photon and proton beams. Med. Phys. 39, 5257–5262 (2012). CrossRefGoogle Scholar
  22. 22.
    Y. Liu. Film dosimeter and method of determining radiation dose using thereof. 2016Google Scholar
  23. 23.
    S. Hang, X. Tang, D. Shu et al., Monte Carlo study of the beam shaping assembly optimization for providing high epithermal neutron flux for BNCT based on D-T neutron generator. J. Radioanal. Nucl. Chem. 310, 1289–1298 (2016). CrossRefGoogle Scholar
  24. 24.
    C.-H. Gong, X.-B. Tang, D.-Y. Shu et al., Optimization of the compton camera for measuring prompt gamma rays in boron neutron capture therapy. Appl. Radiat. Isotopes 124, 62–67 (2017). CrossRefGoogle Scholar
  25. 25.
    H. Yu, X. Tang, D. Shu et al., Influence of neutron sources and 10B concentration on boron neutron capture therapy for shallow and deeper non-small cell lung cancer. Health Phys. 112, 258–265 (2017). CrossRefGoogle Scholar

Copyright information

© China Science Publishing & Media Ltd. (Science Press), Shanghai Institute of Applied Physics, the Chinese Academy of Sciences, Chinese Nuclear Society and Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Xu-Dong Zhang
    • 1
  • Yuan-Hao Liu
    • 1
    • 2
  • Xiao-Bin Tang
    • 1
    Email author
  • Ming-Chen Hsiao
    • 2
  • Wei-Lin Chen
    • 2
  • Chang-Ran Geng
    • 1
  • Wen-Cheng Shao
    • 1
  • Chun-Hui Gong
    • 1
    • 3
  • Silva Bortolussi
    • 3
  • Di-Yun Shu
    • 1
  1. 1.Department of Nuclear Science and TechnologyNanjing University of Aeronautics and AstronauticsNanjingChina
  2. 2.Neuboron Medtech Ltd.NanjingChina
  3. 3.Unit of PaviaNational Institute of Nuclear Physics INFNPaviaItaly

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