Slice-wise reconstruction for low-dose cone-beam CT using a deep residual convolutional neural network

  • Hong-Kai Yang
  • Kai-Chao Liang
  • Ke-Jun Kang
  • Yu-Xiang XingEmail author


Because of the growing concern over the radiation dose delivered to patients, X-ray cone-beam CT (CBCT) imaging of low dose is of great interest. It is difficult for traditional reconstruction methods such as Feldkamp to reduce noise and keep resolution at low doses. A typical method to solve this problem is using optimization-based methods with careful modeling of physics and additional constraints. However, it is computationally expensive and very time-consuming to reach an optimal solution. Recently, some pioneering work applying deep neural networks had some success in characterizing and removing artifacts from a low-dose data set. In this study, we incorporate imaging physics for a cone-beam CT into a residual convolutional neural network and propose a new end-to-end deep learning-based method for slice-wise reconstruction. By transferring 3D projection to a 2D problem with a noise reduction property, we can not only obtain reconstructions of high image quality, but also lower the computational complexity. The proposed network is composed of three serially connected sub-networks: a cone-to-fan transformation sub-network, a 2D analytical inversion sub-network, and an image refinement sub-network. This provides a comprehensive solution for end-to-end reconstruction for CBCT. The advantages of our method are that the network can simplify a 3D reconstruction problem to a 2D slice-wise reconstruction problem and can complete reconstruction in an end-to-end manner with the system matrix integrated into the network design. Furthermore, reconstruction can be less computationally expensive and easily parallelizable compared with iterative reconstruction methods.


Cone-beam CT Slice-wise Residual U-net Low dose Image denoising 


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Copyright information

© China Science Publishing & Media Ltd. (Science Press), Shanghai Institute of Applied Physics, the Chinese Academy of Sciences, Chinese Nuclear Society and Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Hong-Kai Yang
    • 1
    • 2
  • Kai-Chao Liang
    • 1
  • Ke-Jun Kang
    • 1
    • 2
  • Yu-Xiang Xing
    • 1
    • 2
    Email author
  1. 1.Department of Engineering PhysicsTsinghua UniversityBeijingChina
  2. 2.Key Laboratory of Particle and Radiation Imaging, Ministry of EducationTsinghua UniversityBeijingChina

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