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Topics in Current Chemistry

, 376:40 | Cite as

Cyanoacetohydrazides in Synthesis of Heterocyclic Compounds

  • Hajar Hosseini
  • Mohammad BayatEmail author
Review
  • 262 Downloads

Abstract

Use of cyanoacetohydrazides as precursors in reactions leading to construction of heterocycles is reviewed. In addition to some common heterocyclic compounds, synthesis of other uncommon heterocycles such as thiadiazole, oxadiazole, fused heterocycles, and some seven- and eight-membered heterocycles such as benzodiazepine, oxazepine, and benzoxocine starting with cyanoacetohydrazides and their derivatives is also reported. The main aim of this review is to show the application of cyanoacetohydrazides in heterocyclic synthesis via different types of reaction, including cyclocondensation and cyclization. The results are arranged in terms of the type of heterocycle formed, from five-, six-, seven-, to eight-membered and fused rings. This review aims to cover literature up to 2018, showing the distribution of publications involving use of cyanoacetohydrazides for preparation of heterocycles.

Graphical Abstract

Keywords

Cyanoacetohydrazides Cyanoacetic acid hydrazide Heterocycles Cyclization 

Notes

Compliance with Ethical Standards

Conflict of Interest

The authors declare no competing financial interests.

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Authors and Affiliations

  1. 1.Department of Chemistry, Faculty of ScienceImam Khomeini International UniversityQazvinIran

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