Chitosan-Based Matrices Prepared by Gamma Irradiation for Tissue Regeneration: Structural Properties vs. Preparation Method
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In the last decade, new generations of biopolymer-based materials have attracted attention, aiming its application as scaffolds for tissue engineering. These engineered three-dimensional scaffolds are designed to improve or replace damaged, missing, or otherwise compromised tissues or organs. Despite the number of promising methods that can be used to generate 3D cell-instructive matrices, the innovative nature of the present work relies on the application of ionizing radiation technology to form and modify surfaces and matrices with advantage over more conventional technologies (room temperature reaction, absence of harmful initiators or solvents, high penetration through the bulk materials, etc.), and the possibility of preparation and sterilization in one single step. The current chapter summarizes the work done by the authors in the gamma radiation processing of biocompatible and biodegradable chitosan-based matrices for skin regeneration. Particular attention is given to the correlation between the different preparation conditions and the final polymeric matrices’ properties. We therefore expect to demonstrate that instructive matrices produced and improved by radiation technology bring to the field of skin regenerative medicine a supplemental advantage over more conservative techniques.
KeywordsChitosan Gamma irradiation Porous scaffolds Skin substitute Tissue engineering
C2TN/IST authors gratefully acknowledge the Fundação para a Ciência e Tecnologia support through the UID/Multi/04349/2013 project. The authors also acknowledge the International Atomic Energy Agency under the Research Contract No. 18202 for financial support of this work. The authors would also like to thank the Erasmus student Reda Paitian (University of Vilnius, Lithuania) for her collaboration in the preparation and characterization of chitosan-based matrices.
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