The Effect of Platanus orientalis L. Distillate on Mouse Model of Allergic Rhinitis

  • Soheila Alyasin
  • Behjat ManeshianEmail author
  • Nader Tanideh
  • Ramin Miri
  • Masoud Hosseynzadeh
  • Reza Amin
  • Narjes Ebrahimi
Research Paper
Part of the following topical collections:
  1. Biology


Platanus orientalis L. has been used in traditional Persian medicine to treat allergic rhinitis. In this study, the therapeutic effects of P. orientalis L. distillate on allergic rhinitis mouse model were assessed. Furthermore, chemical components of P. orientalis L. were analyzed, using gas chromatography–mass spectrometry. Allergic rhinitis was induced in ninety mice using ovalbumin, and they were divided into six groups (group 1: negative control, experienced no treatment; group 2: positive control, received loratadine; groups 3, 4 and 5: received different amounts of P. orientalis L. distillate, orally and group 6: received intranasal P. orientalis L. distillate). Clinical signs, serum level of interleukin 4 and eosinophil counts of nasal mucosa were determined. α-eudesmol and β-eudesmol were found as the major components of the distillate. Clinical signs improved significantly in the groups that had received P. orientalis L. distillate in comparison with the control group. Also, pathological findings were in favor of decrement in the nasal mucosal eosinophil counts. The serum level of interleukin 4 was not in the detectable ranges in any of the groups. Improving effects of P. orientalis L. distillate were observed in allergic rhinitis mouse models.


Allergic rhinitis Chemical constituents Mouse model Platanus orientalis L. 



Allergic rhinitis


High-power field



P. orientalis L.

Platanus orientalis L.


Traditional Persian Medicine



This study was supported by Shiraz University of Medical Sciences. We are thankful to Mr. Omid Koohi-Hosseynabadi for his contribution in this study. The authors wish to thank Mr. H. Argasi at the Research Consultation Center (RCC) of Shiraz University of Medical Sciences for his invaluable assistance in editing this manuscript.

Author contributions

Soheila Alyasin and Reza Amin designed the study, Behjat Maneshian carried out the experiment and prepared the manuscript, Nader Tanideh was contributed in animal study, Ramin Miri was contributed in plant distillate preparation and constituent analysis, Masoud Hosseynzadeh was contributed in the histological assessments, and Narjes Ebrahimi was contributed in data analysis and manuscript preparation. All authors were involved in manuscript drafting, and have read and approved the manuscript.


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Copyright information

© Shiraz University 2020

Authors and Affiliations

  • Soheila Alyasin
    • 1
    • 2
  • Behjat Maneshian
    • 3
    Email author
  • Nader Tanideh
    • 4
  • Ramin Miri
    • 5
  • Masoud Hosseynzadeh
    • 6
  • Reza Amin
    • 1
    • 2
  • Narjes Ebrahimi
    • 1
  1. 1.Allergy Research CenterShiraz University of Medical SciencesShirazIran
  2. 2.Department of Pediatrics, Division of Allergy and Clinical Immunology, Namazi HospitalShiraz University of Medical ScienceShirazIran
  3. 3.Department of PediatricsShiraz University of Medical SciencesShirazIran
  4. 4.Stem Cells Technology Research Center, Shiraz University of Medical SciencesShirazIran
  5. 5.Medical and Natural Products Chemistry Research Center, School of PharmacyShiraz University of Medical SciencesShirazIran
  6. 6.Department of PathologyShiraz University of Medical SciencesShirazIran

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