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The Effect of Platanus orientalis L. Distillate on Mouse Model of Allergic Rhinitis

  • Soheila Alyasin
  • Behjat ManeshianEmail author
  • Nader Tanideh
  • Ramin Miri
  • Masoud Hosseynzadeh
  • Reza Amin
  • Narjes Ebrahimi
Research Paper
Part of the following topical collections:
  1. Biology

Abstract

Platanus orientalis L. has been used in traditional Persian medicine to treat allergic rhinitis. In this study, the therapeutic effects of P. orientalis L. distillate on allergic rhinitis mouse model were assessed. Furthermore, chemical components of P. orientalis L. were analyzed, using gas chromatography–mass spectrometry. Allergic rhinitis was induced in ninety mice using ovalbumin, and they were divided into six groups (group 1: negative control, experienced no treatment; group 2: positive control, received loratadine; groups 3, 4 and 5: received different amounts of P. orientalis L. distillate, orally and group 6: received intranasal P. orientalis L. distillate). Clinical signs, serum level of interleukin 4 and eosinophil counts of nasal mucosa were determined. α-eudesmol and β-eudesmol were found as the major components of the distillate. Clinical signs improved significantly in the groups that had received P. orientalis L. distillate in comparison with the control group. Also, pathological findings were in favor of decrement in the nasal mucosal eosinophil counts. The serum level of interleukin 4 was not in the detectable ranges in any of the groups. Improving effects of P. orientalis L. distillate were observed in allergic rhinitis mouse models.

Keywords

Allergic rhinitis Chemical constituents Mouse model Platanus orientalis L. 

Abbreviations

AR

Allergic rhinitis

HPF

High-power field

OVA

Ovalbumin

P. orientalis L.

Platanus orientalis L.

TPM

Traditional Persian Medicine

Notes

Acknowledgements

This study was supported by Shiraz University of Medical Sciences. We are thankful to Mr. Omid Koohi-Hosseynabadi for his contribution in this study. The authors wish to thank Mr. H. Argasi at the Research Consultation Center (RCC) of Shiraz University of Medical Sciences for his invaluable assistance in editing this manuscript.

Author contributions

Soheila Alyasin and Reza Amin designed the study, Behjat Maneshian carried out the experiment and prepared the manuscript, Nader Tanideh was contributed in animal study, Ramin Miri was contributed in plant distillate preparation and constituent analysis, Masoud Hosseynzadeh was contributed in the histological assessments, and Narjes Ebrahimi was contributed in data analysis and manuscript preparation. All authors were involved in manuscript drafting, and have read and approved the manuscript.

References

  1. Abolhassanzadeh Z, Aflaki E, Yousefi G, Mohagheghzadeh A (2016) Medicinal plants for joint pain in Traditional Persian Medicine. Trends Pharm Sci 2:89–100Google Scholar
  2. Araújo LU, Grabe-Guimarães A, Mosqueira VCF, Carneiro CM, Silva-Barcellos NM (2010) Profile of wound healing process induced by allantoin. Acta Cir Bras 25:460–461CrossRefGoogle Scholar
  3. Asakura K, Kanemasa T, Minagawa K, Kagawa K, Yagami T, Nakajima M, Ninomiya M (2000) α-Eudesmol, a P/Q-type Ca2+ channel blocker, inhibits neurogenic vasodilation and extravasation following electrical stimulation of trigeminal ganglion. Brain Res 873:94–101CrossRefGoogle Scholar
  4. Benninger MS, Ahmad N, Marple BF (2003) The safety of intranasal steroids. Otolaryngol Head Neck Surg 129:739–750CrossRefGoogle Scholar
  5. Bernstein DI, Bernstein CK, Deng C, Murphy KJ, Bernstein IL, Bernstein JA, Shukla R (2002) Evaluation of the clinical efficacy and safety of grapeseed extract in the treatment of fall seasonal allergic rhinitis: a pilot study. Ann Allergy Asthma Immunol 88:272–278CrossRefGoogle Scholar
  6. Campanati A et al (2010) Effect of allium cepa-allantoin-pentaglycan gel on skin hypertrophic scars: clinical and video-capillaroscopic results of an open-label, controlled, nonrandomized clinical trial. Dermatol Surg 36:1439–1444CrossRefGoogle Scholar
  7. Finkelman FD, Morris SC (1999) Development of an assay to measure in vivo cytokine production in the mouse. Int Immunol 11:1811–1818CrossRefGoogle Scholar
  8. Grzincich G, Capra L, Cammarata MG (2004) Effectiveness of intranasal corticosteroids. Acta Bio Med Atenei Parmensis 75:22–25Google Scholar
  9. Haider S, Nazreen S, Alam MM, Hamid H, Alam MS (2012) Anti-inflammatory and anti-nociceptive activities of Platanus orientalis Linn. and its ulcerogenic risk evaluation. J Ethnopharmacol 143:236–240CrossRefGoogle Scholar
  10. Hatami GAAA, Najafi A, Razavi Sh, Afrasiabi K, Afarid M (2003) Prevalence of symptoms and severity of allergic rhinitis, asthma and ectopic eczema in 13-14 years old students in Booshehr. Iran Sout Med J 2:167–175Google Scholar
  11. Hossen MA, Fujii Y, Ogawa M, Takubo M, Tsumuro T, Kamei C (2005) Effect of loratadine on mouse models of atopic dermatitis associated pruritus. Int Immunopharmacol 5:1331–1336CrossRefGoogle Scholar
  12. Lin L, Zheng C, Zhang L, Da C, Zhao K (2011) 2-Aminoethoxydiphenyl borate administration into the nostril alleviates murine allergic rhinitis. Am J Otolaryngol 32:318–328CrossRefGoogle Scholar
  13. Ma Y, Hurst HE, Fernandez-Botran R (1996) Soluble cytokine receptors as carrier proteins: effects of soluble interleukin-4 receptors on the pharmacokinetics of murine interleukin-4. J Pharmacol Exp Ther 279:340–350Google Scholar
  14. Mirheidar H (1996) Herbal learnings, usage of herbs in prevention and treatment of diseases, vol 3. Islamic Culture Press Center, TehranGoogle Scholar
  15. Miri S, Farid R, Akbari H, Amin R (2006) Prevalence of allergic rhinitis and nasal smear eosinophilia in 11-to 15 yr-old children in Shiraz. Pediatr Allergy Immunol 17:519–523CrossRefGoogle Scholar
  16. Mizuki D, Miura T, Sasaki S, Mizuki M, Madarame H, Nakane A (2001) Interference between host resistance to listeria monocytogenes infection and ovalbumin-induced allergic responses in mice. Infect Immun 69:1883–1888CrossRefGoogle Scholar
  17. Mosaddegh M, Naghibi F, Moazzeni H, Pirani A, Esmaeili S (2012) Ethnobotanical survey of herbal remedies traditionally used in Kohghiluyeh va Boyer Ahmad province of Iran. J Ethnopharmacol 141:80–95CrossRefGoogle Scholar
  18. Nasab FK, Khosravi AR (2014) Ethnobotanical study of medicinal plants of Sirjan in Kerman Province, Iran. J Ethnopharmacol 154:190–197CrossRefGoogle Scholar
  19. Nishanbaev S, Khidyrova N, Kuliev Z (2004) Dimeric proanthocyanidins from platanus orientalis bark. Chem Nat Compd 40:93CrossRefGoogle Scholar
  20. Nishanbaev S, Kuliev Z, Khidyrova N, Vdovin A, Abdullaev N, Shakhidoyatov KM, Aripov O (2010) New oligomeric proanthocyanidin glycosides platanoside-A and platanoside-B from Platanus orientalis trunk bark. Chem Nat Compd 46:357–362CrossRefGoogle Scholar
  21. Nishikubo K et al (2003) A single administration of interleukin-4 antagonistic mutant DNA inhibits allergic airway inflammation in a mouse model of asthma. Gene Ther 10:2119–2125CrossRefGoogle Scholar
  22. Okano M (2009) Mechanisms and clinical implications of glucocorticosteroids in the treatment of allergic rhinitis. Clin Exp Immunol 158:164–173CrossRefGoogle Scholar
  23. Sadat-Hosseini M, Farajpour M, Boroomand N, Solaimani-Sardou F (2017) Ethnopharmacological studies of indigenous medicinal plants in the south of Kerman, Iran. J Ethnopharmacol 199:194–204CrossRefGoogle Scholar
  24. Sadeghi Z, Kuhestani K, Abdollahi V, Mahmood A (2014) Ethnopharmacological studies of indigenous medicinal plants of Saravan region, Baluchistan, Iran. J Ethnopharmacol 153:111–118CrossRefGoogle Scholar
  25. Seo M-J et al (2011) The regulatory mechanism of β-eudesmol is through the suppression of caspase-1 activation in mast cell–mediated inflammatory response. Immunopharmacol Immunotoxicol 33:178–185CrossRefGoogle Scholar
  26. Spector SL (1997) Overview of comorbid associations of allergic rhinitis. JAllergy Clin Immunol 99:S773–S780CrossRefGoogle Scholar
  27. Thai QD et al (2016) Phytochemical study and biological evaluation of chemical constituents of Platanus orientalis and Platanus acerifolia buds. Phytochemistry 130:170–181CrossRefGoogle Scholar
  28. Tsuneki H et al (2005) Antiangiogenic activity of β-eudesmol in vitro and in vivo. Eur J Pharmacol 512:105–115CrossRefGoogle Scholar
  29. Wallace DV et al (2008) The diagnosis and management of rhinitis: an updated practice parameter. J Allergy Clin Immunol 122:S1–S84CrossRefGoogle Scholar
  30. Yamamoto K, Kawamura I, Tominaga T, Nomura T, Ito J, Mitsuyama M (2006) Listeriolysin O derived from Listeria monocytogenes inhibits the effector phase of an experimental allergic rhinitis induced by ovalbumin in mice. Clin Exp Immunol 144:475–484CrossRefGoogle Scholar
  31. Yoshimura M, Enomoto T, Dake Y, Okuno Y, Ikeda H, Cheng L, Obata A (2007) An evaluation of the clinical efficacy of tomato extract for perennial allergic rhinitis. Allergol Int 56:225–230CrossRefGoogle Scholar

Copyright information

© Shiraz University 2020

Authors and Affiliations

  • Soheila Alyasin
    • 1
    • 2
  • Behjat Maneshian
    • 3
    Email author
  • Nader Tanideh
    • 4
  • Ramin Miri
    • 5
  • Masoud Hosseynzadeh
    • 6
  • Reza Amin
    • 1
    • 2
  • Narjes Ebrahimi
    • 1
  1. 1.Allergy Research CenterShiraz University of Medical SciencesShirazIran
  2. 2.Department of Pediatrics, Division of Allergy and Clinical Immunology, Namazi HospitalShiraz University of Medical ScienceShirazIran
  3. 3.Department of PediatricsShiraz University of Medical SciencesShirazIran
  4. 4.Stem Cells Technology Research Center, Shiraz University of Medical SciencesShirazIran
  5. 5.Medical and Natural Products Chemistry Research Center, School of PharmacyShiraz University of Medical SciencesShirazIran
  6. 6.Department of PathologyShiraz University of Medical SciencesShirazIran

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