Cell Phone EMF Affects Rat Pulmonary Tc-MIBI Uptake and Oxidative Stress
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99mTc-MIBI is a radiopharmaceutical which has trend to accumulate in the heart, but its absorption in pulmonary system may alter heart accumulation and so affect the heart imaging. We aimed to assess the effects of cell phone EMF on lung accumulation of 99mTc-MIBI and oxidative stress. Male albino Wistar rats were randomly divided into 12 groups: four for 99mTc and 99mTc-MIBI control, four for 99mTc 900 and 1800 MHz, four for 99mTc-MIBI 900 and 1800 MHz. After injection of radiopharmaceutical in rats’ tail vein, the animals were housed in standard cages for expose to 900 or 1800 MHz in time of 15 or 30 min. Activity of 99mTc and 99mTc-MIBI in the lungs was being assayed using a dose calibrator. Concentration of malondialdehyde (MDA) and catalase (CAT) was measured in serum. After 15 and 30 min EMF radiation, in both groups of 900 and 1800 MHz, lung specific activity was increased the same as control group; meanwhile, in 15 min 900 MHz group, there was a significant increase in lung-to-heart specific activity ratio compared to other groups. Data showed a permanent increase in 900 MHz group CAT activity. MDA level had not any significant changes. The use of cell phone EMF during the preparation and imaging process could increase absorption of radiopharmaceutical by the pulmonary system and may affect lung-to-heart specific activity ratio, so affect to correct diagnosis by the physician.
Keywords99mTc-MIBI Electromagnetic field Oxidative stress Malondialdehyde Catalase Pulmonary system
This work was supported by Grant from Semnan University of Medical Sciences (688) and Iran National Science Foundation (INSF, 93013715). We would like to thank the Research Center of Physiology of Semnan University of Medical Sciences for cooperation and make available facilities to this work.
Compliance with Ethical Standards
Conflict of interest
The authors declared no conflicts of interest.
- Azab EA, Ebrahim SA (2017) Exposure to electromagnetic fields induces oxidative stress and pathophysiological changes in the cardiovascular system. J Appl Biotechnol Bioeng 4:00096Google Scholar
- De Mattos DMM, Dire GF, Lima RC, Almeida ACC, Bellucio D, Azevedo CSS et al (2009) The consequences of the effects of the chemotherapeutic drug (vincristine) in organs and the influence on the bioavailability of two radio-biocomplexes used for bone evaluations in balb/c female mice. Afr J Biotechnol 8(23):6724–6730Google Scholar
- Giubbini R, Campini R, Milan E, Zoccarato G, Orlandi C, Rossini P et al (1995) Evaluation of technetium-99m-sestamibi lung uptake: correlation with left ventricular function. J Nucl Med 36(1):58–63Google Scholar
- Hosseini E, Nafisi S, Zare S (2011) The effects of electromagnetic fields on plasma levels of corticosterone, free-T3, free-T4 malonyldialdehyde in white male rabbit with normal diet and hyperchlostrol diet. Vet Res Forum 2(4):222–225Google Scholar
- Ikinci A, Mercantepe T, Unal D, Erol HS, Sahin A, Aslan A et al (2016) Morphological and antioxidant impairments in the spinal cord of male offspring rats following exposure to a continuous 900 MHz electromagnetic field during early and mid-adolescence. J Chem Neuroanat 75:99–104CrossRefGoogle Scholar
- Jadidi M, Esmaili MH, Hejazi P, Ghorbani R (2017) Changes in rat’s cardiovascular 99mTc-MIBI build-up after cell phone irradiation. Transylv Rev 15(16):4127–4134Google Scholar
- Kouchaki E, Motaghedifard M, Banafshe HR (2016) Effect of mobile phone radiation on pentylenetetrazole-induced seizure threshold in mice. Iran J Basic Med Sci 19:800–803Google Scholar
- Kyparos D, Arsos G, Georga S, Petridou A, Kyparos A, Papageorgiou E et al (2006) Assessment of brown adipose tissue activity in rats by 99mTc-sestamibi uptake. Physiol Res 55(6):653–659Google Scholar
- Mohamed FA, Ahmed AA, El-Kafoury BMA, Lasheen N (2009) Study of the cardiovascular effects of exposure to electromagnetic field. Life Sci J 8(1):260–275Google Scholar
- Moussa SA (2009) Oxidative stress in rats exposed to microwave radiation. Romanian J Biophys 19(2):149–158Google Scholar
- Qiu L, Chen C, Ding G, Zhou Y, Zhang M (2011) The effects of electromagnetic pulse on the protein levels of tight junction associated proteins in the cerebral cortex, hippocampus, heart, lung, and testis of rats. Biomed Environ Sci 24:438–444Google Scholar
- Zhang DY, Xu ZP, Chiang H, Lu DQ, Zeng QL (2006) Effects of GSM 1800 MHz radiofrequency electromagnetic fields on DNA damage in Chinese hamster lung cells. Chin J Dis Control Prev 40:149–152 (in Chinese) Google Scholar