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An Ultrasound-Promoted Efficient Synthesis of New 4-Hydroxy-2(1H)-quinolone-Derived Amino Nitrile Pyridines

  • Krishna Alla
  • S. SarveswariEmail author
Research Paper
  • 44 Downloads

Abstract

Ultrasound-promoted efficient synthesis of new compounds 2-amino-6-(1, 2-dihydro-4-hydroxy-2-oxoquinolin-3-yl)-4-arylpyridine-3-carbonitriles (4ap) from 4-hydroxy-3-((E)-3-arylacryloyl) quinolin-2(1H)-ones (3ap) has been described. The effect of solvent and ultrasound irradiation has been described.

Keywords

Ultrasound irradiation Quinolones Antimicrobial agents Quinolone chalcones Amino nitrile pyridines Malanonitrile Ammonium acetate 

Notes

Acknowledgements

We thank Mr. BRS Rao (Managing Director of LGC Promochem Private Limited, Bangalore) for his financial support. We thank VIT-SIF Vellore for providing NMR facility and SAIF-IIT Madras, Chennai for providing HR-MS analytical service.

Supplementary material

40995_2018_567_MOESM1_ESM.doc (15.4 mb)
Supplementary material 1 (DOC 15721 kb)

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Copyright information

© Shiraz University 2018

Authors and Affiliations

  1. 1.Centre for Organic and Medicinal ChemistryVIT UniversityVelloreIndia
  2. 2.LGC Promochem Private LimitedBangaloreIndia

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