Design and Efficient Synthesis of Novel Biological Benzylidenemalononitrile Derivatives Containing Ethylene Ether Spacers

  • Enayatollah SheikhhosseiniEmail author
  • Shahla Soltaninejad
Research Paper


Knoevenagel condensation reaction of ethylene glycol-based aromatic aldehyde with malononitrile leads to the corresponding benzylidenemalononitrile derivatives which contain high yields of ethylene ether spacers. The product structures were derived from their IR, 1H-NMR, and 13C-NMR spectroscopy. Some of these compounds have been found to possess antibacterial activity.


Knoevenagel condensation Benzylidenemalononitrile Ethylene ether spacer Antibacterial activity 



The authors express appreciation to the Islamic Azad University (Kerman Branch), for supporting this investigation.


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Copyright information

© Shiraz University 2017

Authors and Affiliations

  • Enayatollah Sheikhhosseini
    • 1
    Email author
  • Shahla Soltaninejad
    • 2
  1. 1.Department of Chemistry, Kerman BranchIslamic Azad UniversityKermanIran
  2. 2.Department of Biology, Jiroft BranchIslamic Azad UniversityJiroftIran

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