Design and Efficient Synthesis of Novel Biological Benzylidenemalononitrile Derivatives Containing Ethylene Ether Spacers
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Knoevenagel condensation reaction of ethylene glycol-based aromatic aldehyde with malononitrile leads to the corresponding benzylidenemalononitrile derivatives which contain high yields of ethylene ether spacers. The product structures were derived from their IR, 1H-NMR, and 13C-NMR spectroscopy. Some of these compounds have been found to possess antibacterial activity.
KeywordsKnoevenagel condensation Benzylidenemalononitrile Ethylene ether spacer Antibacterial activity
The authors express appreciation to the Islamic Azad University (Kerman Branch), for supporting this investigation.
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