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Does Polyp-Originated Growing have Prognostic Significance for Stage 1 Endometrioid-Type Endometrial Cancer?

  • İrem Alyazıcı KüçükyıldızEmail author
  • Emre Günakan
  • Hüseyin Akıllı
  • Asuman Nihan Haberal
  • Esra Kuşcu
  • Ali Haberal
  • Ali Ayhan
Original Article
  • 2 Downloads

Abstract

Purpose

Endometrioid-type endometrial cancer is usually diagnosed in the early stages and has a good prognosis. Patients with stage 1 disease have survival rates over 95%. Tumor factors affect survival in these patients, but polyp-originated growing has not been sufficiently discussed in the literature. This study aimed to determine the effect of polyp-originated growing in stage 1 endometrioid-type endometrial cancer and to provide a review of the literature.

Methods

This study includes 318 stage 1 endometrioid-type endometrial cancer patients. The patients were divided into two groups based on the tumor origin. Group I included patients with polyp-originated growing tumors, and Group II included patients with endometrial surface-originated growing tumors.

Results

Groups I and II included 39 and 279 patients, respectively. The general properties of the patients were similar; there were no significant differences. The univariate survival analyses showed that overall survival for Groups I and II was 65.5 and 83.6 months, respectively; this difference was statistically significant (p = 0.002). The multivariate analysis of age, maximum tumor diameter, tumor origin, lymphovascular space involvement, myometrial invasion depth and tumor grade showed that polyp-originated growing was independently and significantly associated with overall survival (HR 4.05; 95% CI 1.2–13.5; p = 0.023).

Conclusion

Polyp-originated growing may be a prognostic factor for early stage endometrioid-type endometrial cancer. The prognostic effect of polyp-originated growing is not well known, and further investigation is necessary.

Keywords

Endometrial polyp Endometrioid-type endometrial cancer Endometrial cancer Overall survival 

Notes

Acknowledgements

This study was not financially supported.

Authors’ Contribution

İAK helped in data collection, analysis or interpretation and manuscript writing; EK contributed to the literature search; EG helped in analysis or interpretation; ANH collected the data; AH and AA contributed to project development; and HA helped in the literature Search.

Compliance with Ethical Standards

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Association of Gynecologic Oncologists of India 2019

Authors and Affiliations

  1. 1.Department of Obstetrics and Gynecology, Cumhuriyet University School of Medicine, MerkezCumhuriyet ÜniversitesiSivasTurkey
  2. 2.Department of Obstetrics and Gynecology, Keçiören Training and Research HospitalUniversity of Medical SciencesAnkaraTurkey
  3. 3.Department of Obstetrics and GynecologyBaskent University School of MedicineAnkaraTurkey
  4. 4.Department of PathologyBaskent University School of MedicineAnkaraTurkey

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