Role of Intraoperative Frozen Section in the Diagnosis of Ovarian Tumors: Experience at Gujarat Cancer and Research Institute
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The surgical management of ovarian tumors depends on their correct categorization as benign, borderline or malignant. Ovarian neoplasms are an important cause of morbidity and mortality in women.
This study was undertaken to evaluate the accuracy of intraoperative frozen section in the diagnosis of various categories of ovarian neoplasms.
Intraoperative frozen section diagnosis was retrospectively evaluated in 292 patients with suspected ovarian neoplasms who underwent surgery as primary line of therapy at our institution. This was compared with the final histopathology diagnosis on paraffin sections.
In 292 patients frozen section report had a sensitivity of 100%, 65% and 96.67% for benign, borderline and malignant tumors, respectively. The corresponding specificities were 94.28%, 99.26%, and 99.42%, respectively. The overall accuracy of frozen section diagnosis was 96.2%. The majority of cases of disagreement were in the mucinous and borderline tumors.
Intraoperative frozen section has high accuracy in the diagnosis of suspected ovarian neoplasms. It is a valuable tool to guide the surgical management of these patients and should be routinely used in all major oncology centers.
KeywordsFrozen section Intraoperative Ovarian tumor Borderline tumor Surgical staging
Compliance with Ethical Standards
Conflict of interest
The authors declare that they have no conflict of interest.
This article does not contain any studies with human participants performed by any of the authors.
Informed consent was obtained from the individual participants included in the study.
- 8.Ivanov S, Ivanov S, Khadzhiolov N. ovarian tumors—accuracy of frozen section diagnosis. Akush Ginekol (Sofiia). 2005;44(1):11–3.Google Scholar
- 11.Slavutin L, Rotterdam H. Frozen section diagnosis of serous epithelial tumors of the ovary. Am J Diagn Obstet Gynecol. 1979;1:89–92.Google Scholar
- 15.Ratnavelu ND, Brown AP, Mallett S, Scholten RJ, Patel A, Founta C, Galaal K, Cross P, Naik R. Intraoperative frozen section analysis for the diagnosis of early stage ovarian cancer in suspicious pelvic masses. Cochrane Database Syst Rev. 2016;3:CD010360. https://doi.org/10.1002/14651858.cd010360.pub2.CrossRefPubMedGoogle Scholar