Advertisement

Large Cell Neuroendocrine Carcinoma of the Uterine Cervix: A Rare Case Report

  • Hemanth Vudayaraju
  • Milap Shah
  • Sowmya Korukonda
Case report

Abstract

Large cell neuroendocrine carcinoma of the uterine cervix is a rare and aggressive malignancy with poor prognosis even in its early stage, despite multimodality treatment strategy. We describe a 37-year-old woman with a large cell neuroendocrine carcinoma admixed with adenocarcinoma of the uterine cervix. These highly aggressive tumors have a prognosis that is much worse than that for stage comparable poorly differentiated squamous cell carcinoma of the cervix. Aggressive initial multimodality treatment with radical hysterectomy, bilateral pelvic lymph node dissection and adjuvant chemotherapy is recommended.

Keywords

Neuroendocrine tumors of cervix Large cell neuroendocrine carcinoma cervix Small cell neuroendocrine carcinoma cervix Adenocarcinoma cervix 

References

  1. 1.
    Albores-Saavedra J, Gersell D, Gilks CB, Henson DE, Lindberg G, Santiago H, et al. Terminology of endocrine tumors of the uterine cervix: results of a workshop sponsored by the College of American Pathologists and the National Cancer Institute. Arch Pathol Lab Med. 1997;121:34–9.PubMedGoogle Scholar
  2. 2.
    Rekhi B, Patil KK, Deodhar AA, Maheshwari R, Kerkar S Gupta, et al. Spectrum of neuroendocrine carcinomas of the uterine cervix, including histopathologic features, terminology, immunohistochemical profile, and clinical outcomes in a series of 50 cases from a single institution in India. Ann Diagn Pathol. 2013;17:1–9.CrossRefPubMedGoogle Scholar
  3. 3.
    Wang K, Wang T, Huang Y, Lai J, Chang T, Yen M. Human papillomavirus type and clinical manifestation in seven cases of large-cell neuroendocrine cervical carcinoma. J Formos Med Assoc. 2009;108(5):428–32.CrossRefPubMedGoogle Scholar
  4. 4.
    Embry JR, Kelly MG, Post MD, Spillman MA. Large cell neuroendocrine carcinoma of the cervix: prognostic factors and survival advantage with platinum chemotherapy. Gynecol Oncol. 2011;120:444–8.CrossRefPubMedGoogle Scholar
  5. 5.
    Bermúdez A, Vighi S, García A, Sardi J. Neuroendocrine cervical carcinoma: a diagnostic and therapeutic challenge. Gynecol Oncol. 2001;82:32–9.CrossRefPubMedGoogle Scholar
  6. 6.
    Noda K, Nishiwaki Y, Kawahara M, Negoro S, Sugiura T, Yokoyama A, et al. Irinotecan plus cisplatin compared with etoposide plus cisplatin for extensive small-cell lung cancer. N Engl J Med. 2002;346:85–91.CrossRefPubMedGoogle Scholar
  7. 7.
    Tanimoto H, Hamasaki A, Akimoto Y, Honda H, Takao Y, Okamoto K, et al. A case of large cell neuroendocrine carcinoma (LCNEC) of the uterine cervix successfully treated by postoperative CPT-11+ CDDP chemotherapy after non-curative surgery. Gan To Kagaku Ryoho. 2012;39:1439–41.PubMedGoogle Scholar
  8. 8.
    Omori Makiko, Hashi Akihiko, Kondo Tetsuo, Tagaya Hikaru, Hirata Shuji. Successful neoadjuvant chemotherapy for large cell neuroendocrine carcinoma of the cervix: a case report. Gynaecol Oncol Case Rep. 2014;8:4–6.CrossRefGoogle Scholar

Copyright information

© Association of Gynecologic Oncologists of India 2016

Authors and Affiliations

  • Hemanth Vudayaraju
    • 1
  • Milap Shah
    • 1
  • Sowmya Korukonda
    • 2
  1. 1.Yashoda Superspeciality HospitalSecunderabad, HyderabadIndia
  2. 2.Department of Surgical OncologyYashoda Superspeciality HospitalSecunderabad, HyderabadIndia

Personalised recommendations