Objective Evaluation of Cervical Dystonia Using an Inertial Sensor-Based System
- 5 Downloads
Cervical dystonia (CD) is a chronic neurological movement disorder that causes involuntary neck muscle contractions, leading to abnormal movements or posture of the head. However, objective evaluation of severity of CD is lacking in the clinical practice. This study aimed to provide an objective evaluation of the severity of CD based on three-dimensional (3D) kinematics of the neck using wearable inertial sensors. Each inertial sensor was attached to the anterior chest and head of eight patients with idiopathic CD. The involuntary movements of neck were quantified by the rotation angle (RA) and magnitude of angular velocity (MAV) through axis-angle representation expressing 3D rotation. The characteristic posture of each patient was visualized. Four kinematic parameters, the mean and peak values of RA and MAV (Meanangle, Peakangle, Meanvel, and Peakvel) were calculated and correlation between each parameter values and the Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS) scores from all patients was analyzed to assess clinical validity. The test–retest reliability of the parameters was examined as well. Correlation coefficients of the Meanangle and Peakangle with TWSTRS were 0.28 and 0.69, respectively, whereas those of the Meanvel and Peakvel were 0.84 and 0.84, respectively. The MAV parameters showed a higher correlation with clinical severity than RA parameters. The intraclass correlation coefficients of the four parameters between the test–retest were more than 0.9. We conclude that objective evaluation of severity of CD based on kinematic parameters is clinically valid and has test–retest reliability.
KeywordsCervical dystonia Inertial sensor Objective evaluation Euler angle Axis-angle Kinematics
This research was supported by the Bio & Medical Technology Development Program of the National Research Foundation funded by the Korean government (MEST) (NRF-2016M3A9F1941984).
Compliance with Ethical Standards
Conflict of interest
The authors declare that they have no conflict of interest.
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
Informed consent was obtained from all individual participants included in the study.
- 2.Costa, J., Espírito-Santo, C., Borges, A. A., Ferreira, J., Coelho, M. M., Moore, P., et al. (2005). Botulinum toxin type A therapy for cervical dystonia. The Cochrane Databases Systemic Review, 25(1), CD003633.Google Scholar
- 8.Carpaneto, J., Micera, S., Galardi, G., Micheli, A., Carboncini, M. C., Rossi, B., et al. (2004). A protocol for the assessment of 3D movements of the head in persons with cervical dystonia. Clinical Biomechanics, 19(7), 659–663. https://doi.org/10.1016/j.clinbiomech.2004.04.003.CrossRefGoogle Scholar
- 13.Song, Y. S., Yang, K. Y., Youn, K., Yoon, C., Yeom, J., Hwang, H., et al. (2016). Validation of attitude and heading reference system and microsoft kinect for continuous measurement of cervical range of motion compared to the optical motion capture system. Annals of rehabilitation medicine, 40(4), 568–574.CrossRefGoogle Scholar
- 15.Gregori, B., Agostino, R., Bologna, M., Dinapoli, L., Colosimo, C., Accornero, N., et al. (2008). Fast voluntary neck movements in patients with cervical dystonia: a kinematic study before and after therapy with botulinum toxin type A. Clinical Neurophysiology, 119(2), 273–280. https://doi.org/10.1016/j.clinph.2007.10.007.CrossRefGoogle Scholar