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Journal of Medical and Biological Engineering

, Volume 37, Issue 6, pp 936–943 | Cite as

Optomagnetic Imaging Spectroscopy Application in Cervical Dysplasia and Cancer Detection: Comparation of Stained and Unstained Papanicolaou Smears

  • Branislava Jeftic
  • Milena Papic-Obradovic
  • Jelena Muncan
  • Lidija Matija
  • Djuro Koruga
Original Article

Abstract

Cervical cancer is the fourth most common cancer worldwide. The fact that cervical cancer takes many years to develop indicates that mortality rates can be significantly decreased with early detection. This is why screening tests for early cervical cancer detection are so important, especially in developing countries where screening programs are not available to the same extent as in developed countries. About 84% of all cervical cancer cases in 2012 occurred in less developed countries mainly due to the lack of effective screening programs. Even if the necessary infrastructure in one country exists, the cost of screening test is usually too high. Finally, the accuracy of screening test needs to be satisfying in order to detect all the abnormal cases and treat them effectively. Papanicolaou test is still the most effective screening test for cervical cancer detection so far. However, the accuracy of Papanicolaou test is closely related to the expertise of the cytopathologist and therefore the accuracy varies producing relatively low sensitivity of Papanicolaou test (50–85%). HPV DNA test is approved as primary screening test, but so far it gives better results when it is used in conjunction with cytology. We present a method and device for detection of cervical cancer based on optomagnetic imaging spectroscopy (OMIS) and compare the results for cancer detection using stained and fresh unstained cervical cell samples. Compared to stained samples, unstained fresh sample classification by OMIS into healthy/cancerous group with Naïve Bayes classifier gave higher accuracy (96% compared to 85,18%).

Keywords

Cervical cancer Screening Imaging spectroscopy Automated detection Device 

Notes

Acknowledgements

This research has been funded by the Ministry of Education, Science and Technological Development of the Republic of Serbia, through Project III 41006.

Compliance with Ethical Standards

Ethical Approval

Experiments were approved by the institutional Ethics Committee and carried out after patient approval.

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Copyright information

© Taiwanese Society of Biomedical Engineering 2017

Authors and Affiliations

  1. 1.Faculty of Mechanical Engineering, Department of Biomedical EngineeringUniversity of BelgradeBelgradeSerbia
  2. 2.Clinic of Gynaecology and Obstetrics – Narodni FrontBelgradeSerbia

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