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Preoperative Treatment Planning Method for Magnetically Induced Hyperthermia Using Thermoseeds

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Abstract

This paper proposes a preoperative planning method for magnetically induced hyperthermia (MIH) using ferromagnetic thermoseeds based on clinical computed tomography images. Combined with external alternating magnetic field excitation, the heating model of millimeter-sized cylindrical thermoseeds and the three-dimensional (3D) tissue bio-heat conduction model are established. The Arrhenius model is employed to evaluate the thermal injury degree of tumors and surrounding normal tissues. Based on these methods, MIH treatment planning system software is developed, where the 3D real-time model of patient anatomy is reconstructed with graphics processing unit-accelerated visualization techniques, organs and tumors are segmented, and thermoseeds are conformal-implanted to establish the temperature field distribution and the necrosis zone. This paper can provide guidance on establishment of a rational MIH preoperative planning to prediction and control of the effective therapeutic region.

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Acknowledgments

This work was supported by the Beijing Municipal Science and Technology Commission (Grant Z11110006-7311053) and the National Science and Technology Support Program of China (Grant 2012BAI15B04).

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Authors and Affiliations

  1. Key Laboratory of Particle Technology and Radiation Imaging of Ministry of Education, Institute of Medical Physics and Engineering, Department of Engineering Physics, Tsinghua University, Beijing, 100084, China

    Heng Wang, Jianan Wu, Xianwen Zhang, Zihan Zhuo & Jintian Tang

  2. School of Electrical Engineering, Hebei University of Technology, Tianjin, 300401, China

    Ye Liu & Xi Zheng

  3. Tsinghua University, Room 205, Gongwu Building, Haidian District, Beijing, 100084, China

    Jintian Tang

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  1. Heng Wang
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  2. Jianan Wu
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  3. Xianwen Zhang
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  4. Ye Liu
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  5. Xi Zheng
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  6. Zihan Zhuo
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  7. Jintian Tang
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Correspondence to Jintian Tang.

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Wang, H., Wu, J., Zhang, X. et al. Preoperative Treatment Planning Method for Magnetically Induced Hyperthermia Using Thermoseeds. J. Med. Biol. Eng. 36, 726–732 (2016). https://doi.org/10.1007/s40846-016-0171-7

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  • DOI: https://doi.org/10.1007/s40846-016-0171-7

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