Multiplexing technology for in vitro diagnosis of pathogens: the key contribution of phosphorus dendrimers
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After the microbiology based on Pasteur’s method and polymerase chain reaction (PCR), the diagnosis company named Dendris has proposed a third-generation of diagnosis enabling the search of a broad range of pathogens with strong sensitivity and specificity. This extraordinary profile was possible thanks to the use of phosphorus dendrimers for which various techniques of deposition on a given support were investigated and described and analyzed in this report.
Keywordsphosphorus dendrimers diagnosis DNA arrays multiplexing technology
This work was supported by the National Research Agency (Agence Nationale pour la Recherche), “BIOTECHNOLOGIES” program (ANR 2010 BIOT 004 06: Project INNODIAG to JMF) and by Region Midi Pyrénées (06001324 & 07006292) to RF and JMF and by CNRS (JPM, AMC).
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