Science China Materials

, Volume 61, Issue 11, pp 1454–1461 | Cite as

Multiplexing technology for in vitro diagnosis of pathogens: the key contribution of phosphorus dendrimers

  • Jean Pierre Majoral
  • Jean Marie François
  • Richard Fabre
  • Alice Senescau
  • Serge Mignani
  • Anne-Marie Caminade


After the microbiology based on Pasteur’s method and polymerase chain reaction (PCR), the diagnosis company named Dendris has proposed a third-generation of diagnosis enabling the search of a broad range of pathogens with strong sensitivity and specificity. This extraordinary profile was possible thanks to the use of phosphorus dendrimers for which various techniques of deposition on a given support were investigated and described and analyzed in this report.


phosphorus dendrimers diagnosis DNA arrays multiplexing technology 



This work was supported by the National Research Agency (Agence Nationale pour la Recherche), “BIOTECHNOLOGIES” program (ANR 2010 BIOT 004 06: Project INNODIAG to JMF) and by Region Midi Pyrénées (06001324 & 07006292) to RF and JMF and by CNRS (JPM, AMC).


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Copyright information

© Science China Press and Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Jean Pierre Majoral
    • 1
    • 2
    • 3
  • Jean Marie François
    • 3
    • 4
  • Richard Fabre
    • 3
  • Alice Senescau
    • 3
  • Serge Mignani
    • 5
  • Anne-Marie Caminade
    • 1
    • 2
  1. 1.Laboratoire de Chimie de Coordination du CNRSToulouse Cedex 4France
  2. 2.LCC-CNRS Université de Toulouse, CNRSToulouseFrance
  3. 3.DendrisLabègeFrance
  4. 4.LISBP, UMR CNRS 5504 INRA 792Toulouse Cedex 04France
  5. 5.Laboratoire de Chimie et de Biochimie Pharmacologiques et ToxicolgiqueUniversité Paris Descartes PRES Sorbonne Paris Cité, CNRS-UMR 860ParisFrance

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