Updates in Healthcare Maintenance and Monitoring of Children with Inflammatory Bowel Disease in the Era of Biologic Therapies

  • Trusha PatelEmail author
  • Andrew B. Grossman
Pediatric Gastroenterology (SA Saeed and K Sandberg, Section Editors)
Part of the following topical collections:
  1. Topical Collection on Pediatric Gastroenterology


Purpose of Review

As the therapeutic armamentarium for the management of pediatric inflammatory bowel disease (IBD) expands, it is increasingly challenging for pediatric gastroenterologists and pediatric primary care providers to stay abreast of the available therapies and the associated side effects, required monitoring, and specific health maintenance needs for these patients. Here, we review the currently available therapies and general treatment strategies for the management of pediatric IBD, along with clinical considerations in the context of general pediatric care.

Recent Findings

The number of therapies for the management of IBD has grown rapidly in recent years. While pediatric providers have become adept with the use of anti-tumor necrosis factor-alpha therapies, and large safety registries have helped us understand the risks of these biologic agents, there is much left to learn about the pediatric use of newer therapies, such as vedolizumab, ustekinumab, and tofacitinib.


Biologic therapies and other targeted anti-inflammatory therapies are increasingly used in children with IBD. Pediatric primary care providers and pediatric gastroenterologists must be aware of the risks, benefits, and additional implications of these therapies. Vaccination strategies, recognition and management of routine or opportunistic infections, assessment of rashes, and cancer screening represent areas of particular importance in these children.


Inflammatory bowel disease (IBD) Infliximab Adalimumab Ustekinumab Vedolizumab Tofacitinib 


Compliance with Ethical Standards

Conflict of Interest

The authors declare no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

References and Recommended Reading

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Authors and Affiliations

  1. 1.Division of Gastroenterology, Hepatology and NutritionChildren’s Hospital of PhiladelphiaPhiladelphiaUSA
  2. 2.Perelman School of MedicineUniversity of PennsylvaniaPhiladelphiaUSA

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