Advertisement

SMART Biosensor for Early Diagnostic Detection of Metal Ion Release in Orthopedic Patients: Initial Outcome

  • Mathew T. Mathew
  • Thymur Chaudhary
  • Michael Jacobs
  • Divya Bijukumar
  • Markus A. Wimmer
  • Nadim Hallab
  • Joshua Jacobs
  • Shalini Prasad
Article
  • 14 Downloads
Part of the following topical collections:
  1. Advances in Biosensors

Abstract

Metal ion release from the orthopedic implants is a great concern for the clinicians and patients. Currently, the inductive coupled plasma-mass spectroscopy (ICP-MS) technique is used to detect and estimate the metal ions in the blood or synovial fluid, which is expensive and needs technical assistance. Hence, the aim of the current work is to develop a biosensor based on the electrochemistry to measure the metal release to the body fluids (blood or synovial fluid) from the implants. This will work very similar to a glucometer (by function), as a patient-driven technique, if it is optimized for the blood samples, and for clinical purpose, in case of the synovial fluid estimation. As a proof of concept effort, the present study has two objectives: (1) To study the effectiveness of using a micro-chip biosensor as a diagnostic technique for the early detection of the released metal particles in the synovial fluid solution (study 1), and (2) to investigate the corrosion kinetics of CoCrMo alloy in the presence of metal particles in synovial fluid solution (study 2). A series of tests were done with biosensor prototype with increasing concentration of metal release (particles and ions), which is generated from a hip simulator (study 1). The impedance variation (delta Z) shows a very close correlation with increased amount of metal release (particles and ions) level (study 2). Although the study has several limitations, the initial findings indicate that a biosensor could be developed as a diagnostic tool to detect the metal release (particles and ions) levels.

Keywords

Impedance Biosensor Metal ion/debris Hip implants 

Notes

Acknowledgements

The authors would like to thank NIH (R03 AR064005), NSF (FDN 1160951), Prof. Kunze, Hamburg, Germany (ICP-MS metal ion estimation) and Dean’s Fellowship (RUSH). Special thanks to Dr. Michel Laurent (Rush Orthopedics) for the valuable suggestion to improve this project and other collaborators of this project Prof. K. Shull (Northwestern University), Dr. Danieli Rodrigues (UTD, Dallas) and Dr. Asimina Kiourti (OSU, Columbus).

References

  1. 1.
    Cook RB et al (2013) Pseudotumour formation due to tribocorrosion at the taper interface of large diameter metal on polymer modular total hip replacements. J Arthroplasty 28:1430–1436CrossRefGoogle Scholar
  2. 2.
    Sansone V, Pagani D, Melato M (2013) The effects on bone cells of metal ions released from orthopaedic implants. A review. Clin Cases Miner Bone Metab 10:34–40Google Scholar
  3. 3.
    Hallab NJ (2009) A review of the biologic effects of spine implant debris: fact from fiction. SAS J 3:143–160CrossRefGoogle Scholar
  4. 4.
    Mathew MT, Jacobs JJ, Wimmer MA (2012) Wear-corrosion synergism in a CoCrMo hip bearing alloy is influenced by proteins. Clin Orthop 470:3109–3117CrossRefGoogle Scholar
  5. 5.
    Yan Y et al (2010) M-16 a new tool to assess corrosion and metal ion release in artificial hip joints. J Biomech 43, (Supplement 1):S58CrossRefGoogle Scholar
  6. 6.
    Mistry JB et al (2016) Trunnionosis in total hip arthroplasty: a review. J Orthop Traumatol 17:1–6CrossRefGoogle Scholar
  7. 7.
    Gilbert JL, Buckley CA, Jacobs JJ (1993) In vivo corrosion of modular hip prosthesis components in mixed and similar metal combinations. The effect of crevice, stress, motion, and alloy coupling. J Biomed Mater Res 27:1533–1544CrossRefGoogle Scholar
  8. 8.
    Hallab NJ, Messina C, Skipor A, Jacobs JJ (2004) Differences in the fretting corrosion of metal-metal and ceramic-metal modular junctions of total hip replacements. J Orthop Res 22:250–259CrossRefGoogle Scholar
  9. 9.
    Bosker BH et al (2015) Pseudotumor formation and serum ions after large head metal-on-metal stemmed total hip replacement. Risk factors, time course and revisions in 706 hips. Arch Orthop Trauma Surg 135:417–425CrossRefGoogle Scholar
  10. 10.
    Davies AP (2005) An unusual lymphocytic perivascular infiltration in tissues around contemporary metal-on-metal joint replacements. J Bone Joint Surg 87:18CrossRefGoogle Scholar
  11. 11.
    Huber M, Reinisch G, Trettenhahn G, Zweymüller K, Lintner F (2009) Presence of corrosion products and hypersensitivity-associated reactions in periprosthetic tissue after aseptic loosening of total hip replacements with metal bearing surfaces. Acta Biomater 5:172–180CrossRefGoogle Scholar
  12. 12.
    Robinson PG, Wilkinson AJ, Meek RMD (2014) Metal ion levels and revision rates in metal-on-metal hip resurfacing arthroplasty: a comparative study. Hip Int J Clin Exp Res Hip Pathol Ther 24:123–128Google Scholar
  13. 13.
    Hart A et al (2014) Surveillance of patients with metal-on-metal hip resurfacing and total hip prostheses: a prospective cohort study to investigate the relationship between blood metal ion levels and implant failure. J Bone Joint Surg 96:1091–1099CrossRefGoogle Scholar
  14. 14.
    Posada OM, Tate RJ, Grant MH (2015) Toxicity of cobalt–chromium nanoparticles released from a resurfacing hip implant and cobalt ions on primary human lymphocytes in vitro. J Appl Toxicol 35:614–622CrossRefGoogle Scholar
  15. 15.
    Hosman AH et al (2012) The influence of Co–Cr and UHMWPE particles on infection persistence: an in vivo study in mice. J Orthop Res 30:341–347CrossRefGoogle Scholar
  16. 16.
    Wagner P et al (2012) Metal-on-metal joint bearings and hematopoetic malignancy. Acta Orthop 83:553–558CrossRefGoogle Scholar
  17. 17.
    Ba M, Ng LM, S. & Jj S (2016) Progressive cardiomyopathy in a patient with elevated cobalt ion levels and bilateral metal-on-metal hip arthroplasties. Am J Orthop Belle Mead NJ 45:E132–E135Google Scholar
  18. 18.
    Amstutz HC et al (2013) Do ion concentrations after metal-on-metal hip resurfacing increase over time? A prospective study. J Arthroplasty 28:695–700CrossRefGoogle Scholar
  19. 19.
    Kunze J, Wimmer MA, Reich M, Koelling S, Jacobs JJ. (2005) The effects of residual carbon on the determination of chromium in blood and tissue sample using Quadrupole ICP-MS. At Spectrosc 26, 8–13Google Scholar
  20. 20.
    Bansod B, Kumar T, Thakur R, Rana S, Singh I (2017) A review on various electrochemical techniques for heavy metal ions detection with different sensing platforms. Biosens Bioelectron 94:443–455CrossRefGoogle Scholar
  21. 21.
    Pichetsurnthorn P, Vattipalli K, Prasad S (2012) Nanoporous impedemetric biosensor for detection of trace atrazine from water samples. Biosens Bioelectron 32:155–162CrossRefGoogle Scholar
  22. 22.
    Comeaux R, Novotny P (2009) Biosensors: properties, materials and applications. Nova Sci PublGoogle Scholar
  23. 23.
    Shanmugam NR, Muthukumar S, Prasad S (2016) Ultrasensitive and low-volume point-of-care diagnostics on flexible strips—a study with cardiac troponin biomarkers. Sci Rep 6Google Scholar
  24. 24.
    Panneer Selvam A, Muthukumar S, Kamakoti V, Prasad S (2016) A wearable biochemical sensor for monitoring alcohol consumption lifestyle through Ethyl glucuronide (EtG) detection in human sweat. Sci Rep 6Google Scholar
  25. 25.
    Munje RD, Muthukumar S, Selvam AP, Prasad S (2015) Flexible nanoporous tunable electrical double layer biosensors for sweat diagnostics. Sci Rep 5:srep14586CrossRefGoogle Scholar
  26. 26.
    Munje RD, Muthukumar S, Jagannath B, Prasad S (2017) A new paradigm in sweat based wearable diagnostics biosensors using Room Temperature Ionic Liquids (RTILs). Sci Rep 7:1950CrossRefGoogle Scholar
  27. 27.
    Atrey A et al (2017) 601 metal-on-metal total hip replacements with 36 mm heads a 5 minimum year follow up: levels of ARMD remain low despite a comprehensive screening program. J Orthop 14:108–114CrossRefGoogle Scholar
  28. 28.
    Cooper HJ (2016) Diagnosis and treatment of adverse local tissue reactions at the head-neck junction. J Arthroplasty.  https://doi.org/10.1016/j.arth.2016.02.082 CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2018

Authors and Affiliations

  1. 1.Department of OrthopedicsRush University Medical CenterChicagoUSA
  2. 2.Department of Biomedical ScienceUIC School of MedicineRockfordUSA
  3. 3.Department of BioengineeringUniversity of Texas, DallasDallasUSA

Personalised recommendations