Mild Sleep-Disordered Breathing and Cardiovascular Disease Risk
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Purpose of Review
Sleep-disordered breathing, particularly obstructive sleep apnea (OSA), was identified to impact several health outcomes and physiopathological processes, most notably cardiovascular disease (CVD). However, much less research had addressed the impact of mild OSA as a risk factor for symptomatic CVD. The purpose of this review is to assess the evidence regarding mild OSA and its association with CVD and whether treatment of mild OSA is effective at preventing adverse cardiovascular outcomes.
There is absence of recent large-scale randomized clinical trials that address the impact of mild OSA and its therapy on the risk of CVD. Findings from recent studies are inconsistent and do not support the use of continuous positive airway pressure therapy for the sole purpose of preventing adverse cardiovascular outcomes in patients with mild OSA.
There is limited or uncertain evidence pertaining to the impact of mild OSA and its therapy on CVD. Future research is mandated to further elucidate this critical topic.
KeywordsSleep-disordered breathing Mild obstructive sleep apnea Cardiovascular disease
Dr. Badr is supported by the Department of Veterans Affairs (VA RR&D 1I01RX002116-01) and NHLBI (R01HL130552). Dr. Martin is supported by the VA Greater Los Angeles Healthcare System, Geriatric Research, Education, and Clinical Center (GRECC); National Heart Lung and Blood Institute (Martin K24HL143055) of the National Institutes of Health.
Compliance with Ethical Standards
The content of this work is solely the responsibility of the authors and does not necessarily represent the official views of the Department of Veterans Affairs, National Institutes of Health, or the U.S. Government.
Conflict of Interest
Salam Zeineddine and M. Safwan Badr each declare no conflicts of interest.
Jennifer Martin reports a grant from NIH/NHLBI during the conduct of the study and membership of the Board of Directors of the American Academy of Sleep Medicine.
Human and Animal Rights Informed Consent
This article does not contain any studies with human or animal subjects performed by any of the authors.
Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance
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