Anthropogenic Aerosol Influences on Mixed-Phase Clouds
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Aerosol effects on mixed-phase clouds (MPCs) are more complex than in warm clouds because aerosol particles can act both as cloud condensation nuclei and as ice nucleating particles and more microphysical pathways exist. Stratiform MPCs are most prevalent in the Arctic where cloud top cooling enables heterogeneous ice formation and in orographic terrain where large updrafts prevail. Recently, aerosol effects on stratiform MPCs have also been considered in global climate models. The estimated effective aerosol radiative forcing due to aerosol-cloud and aerosol-radiation interactions (ERFaci + ari) at the top-of-the-atmosphere (TOA) in stratiform warm and MPCs, which is an update of the estimate given in the fifth assessment report (AR5) of the Intergovernmental Panel of Climate Change, is −1.2 W m−2 with a 5–95 % range between −0.8 and −2.0 W m−2. Since AR5, only one new estimate of ERFaci+ari including aerosol effects on both stratiform and convective clouds of −1.4 W m−2 has been published. In all cases, ERFaci+ari is dominated by changes in the shortwave TOA radiation with changes in the longwave TOA radiation amounting to 0.15 W m−2.
KeywordsAnthropogenic aerosols Aerosol radiative forcing Mixed-phase clouds Global climate models
Emissions of anthropogenic aerosols and their precursor gases have substantially increased since pre-industrial times. Some anthropogenic aerosols, such as sulfates, nitrates, and some organic aerosols, are hygroscopic or hydrophilic. They are good cloud condensation nuclei (CCN) and with that influence the microphysical properties of warm clouds, denoting clouds consisting purely of liquid water. An increase in CCN leads to more cloud droplets. If the same amount of water vapor condenses on more cloud droplets, the cloud droplets cannot grow as large and will be smaller. The total cross-sectional area of the polluted (anthropogenically influenced) cloud thus is higher and reflects more solar radiation back to space. This effect is known as the Twomey effect  or radiative forcing due to aerosol-cloud interactions (RFaci, ).
In addition, rapid adjustments occur that further modify the radiative budget at TOA through changes within the atmosphere or at the surface. These adjustments operate on timescales that are much shorter than the timescale of global warming and are distinguished from feedbacks which operate through changes in climate variables as a response to a change in surface temperature. In a cloud that consists of smaller cloud droplets, the droplets are less likely to collide and coalesce, which retards precipitation formation . If such a delay increases the cloud’s lifetime or causes faster evaporation of the small droplets is still unclear . Other fast adjustments include changes in the phase of the cloud or changes in its coverage. These adjustments are included in the effective radiative forcing due to aerosol-cloud interactions (ERFaci, being the sum of RFaci and fast adjustments). The majority of the estimates of ERFaci from global climate models (GCMs) is more negative than RFaci alone . In the global annual mean ERFaci + ari that includes also the radiative forcing due to aerosol-radiation interactions (ari) was estimated to be −0.9 W m−2 in IPCC AR5  with an uncertainty range of −0.1 to 1.9 W m−2. Since then, a number of new estimates has been published using state-of-the-art GCMs, all of which arrive at a more negative ERFaci + ari [13, 23, 24, 31, 44, 61, 83, 86, 104]. Even the study that is based on satellite observations reports an ERFaci + ari of −0.95 W m−2 , which is at the upper end of the satellite-based estimates in IPCC AR5 .
Stratiform mixed-phase clouds (MPCs) or layers of mixed-phase in nimbostratus clouds can be found at temperatures between 0 and −38∘C and contain both supercooled liquid water and ice. More precisely, Korolev et al. (2003) defined MPCs as clouds in which the ratio of the ice water content to the sum of the liquid water and ice water content was measured to be between 0.1 and 0.9 . Convective clouds with a large vertical extent and cold cloud top temperatures can also have a mixed-phase region. These clouds and possible aerosol effects on them are discussed in the “Aerosol Effects on Deep Convective Clouds” section. The majority of precipitation in mid-latitudes originates in clouds containing ice  but melts to raindrops or drizzle drops on the way to the ground. While precipitation from pure ice clouds (e.g., high cirrus clouds) rarely reaches the ground, the precipitation-forming clouds are mainly MPCs (stratiform and convective) in which ice crystals quickly grow to precipitation-sized particles and leave the cloud. Because of the larger sizes of ice crystals and their smaller index of refraction as compared to cloud droplets, even for the same water content ice clouds are optically thinner than liquid water clouds. Taking into account that precipitation reduces the water content of glaciated clouds, they are optically much thinner and reflect much less shortwave radiation back to space than liquid water clouds. This effect is partly compensated by a reduced emission in the longwave. In short, knowledge about the size distribution of cloud droplets and ice crystals in MPCs is important both for the hydrological cycle and the radiation budget.
In this article, I will first discuss the microphysical processes in MPCs (“Aerosol Effects on Stratiform and Shallow Convective MPCs”), then discuss anthropogenic aerosol effects on stratiform MPCs (“Aerosol Effects on Stratiform and Shallow Convective MPCs”), orographic MPCs (“Aerosol Effects on Orographic MPCs”), and on deep convective clouds (“Aerosol Effects on Deep Convective Clouds”) before discussing global estimates of ERFaci + ari in the “Aerosol Radiative Forcing Due to Aerosol-Cloud and Aerosol-Radiation Interactions” section and finishing with conclusions.
Microphysical Processes and Aerosol Effects in MPCs
MPCs are thermodynamically unstable because the saturation vapor pressure over ice is smaller than over supercooled liquid water. If the environmental vapor pressure lies between the saturation vapor pressure of supercooled water and ice, then the ice crystals grow at the expense of the evaporating water droplets. This process is called the Wegener-Bergeron-Findeisen (WBF) process [4, 21, 100]. The result of this process can be observed in so-called hole punch clouds [30, 71] (Fig. 1), where in the wake of an aircraft penetrating the supercooled liquid cloud, locally the temperature decreases sufficiently for ice formation. Due to the WBF process, ice crystals have grown large enough to sediment out of the cloud.
The effect of anthropogenic aerosols on MPCs is much more uncertain than on warm clouds because more microphysical processes exist and also changes in the liquid phase can influence MPCs. For instance, a delay of the warm rain process due to more and smaller cloud droplets as discussed above keeps more condensate in the cloud so that more latent heat can be released upon freezing. This effect is partly compensated by the additional weight of the condensed water that reduces the buoyancy inside the cloud. The net increase in buoyancy in polluted as compared to clean clouds has been made responsible for the invigoration of deep convective clouds  and been referred to as the thermodynamic indirect effect —see the “Aerosol Effects on Deep Convective Clouds” section.
In addition to changes in the number concentration and size of cloud droplets, changes in MPCs can be triggered by a change in the number concentration of anthropogenic aerosols can act as ice nucleating particles (INP). INP differ from CCN in that they need to have active sites that can stabilize ice germ formation. The identity of what constitutes an active site is still unknown and area of active research . Many previous studies have suggested that INP need to be solid or crystalline and typically have diameters larger than 0.1 μm [62, 75], examples of which are mineral dusts [34, 72], biological particles such as bacteria, fungal spores, and pollen , but can also be biogenic particles from the ocean surface, oxidized biogenic forest emissions, or macromolecules from plant and ocean matter [76, 77, 102].
So far, it is neither known if carbonaceous aerosols are good INP nor if anthropogenic activity has increased the INP concentration. If soot aerosols, agricultural dusts, industrial metal particles, ashes, and/or biomass burning particles were good INP, then INP would have increased through anthropogenic activity causing an increase in the ice crystal number concentration (ICNC) assuming the macroscopic conditions causing cloud formation remain unchanged. Due to the WBF process, an increase in ICNC leads to a faster glaciation of supercooled liquid clouds and MPCs, an increase in precipitation, a decrease in cloud cover, and a reduction in reflected shortwave (SW) radiation . This so-called glaciation effect buffers some of the initial perturbations in warm clouds through a decrease in the coverage and water content of the overlying clouds in the mixed-phase temperature range between 0 and −38∘C. In addition, ice crystals and snow flakes from these clouds accrete with cloud hydrometeors (cloud droplets and ice crystals) in lower-lying clouds and reduce also their water content. Suggestions for such a buffering were found in preliminary studies with the Norwegian Earth System Model (NorESM)  and can be explained theoretically .
If, however, the main effect of anthropogenic activity were a coating of INPs with acids (sulfuric acid, nitric acid), this would reduce their ice nucleating ability and result in fewer ice crystals that grow to larger sizes and sediment more readily without converting the whole MPC into an ice cloud . Alternatively, ice may only form at colder temperatures. In any case, this so-called deactivation effect causes an increase in the amount of supercooled liquid water and operates in the same direction as ERFaci for warm clouds. The deactivation effect seems to dominate over the glaciation indirect effect in some GCMs [33, 91].
Aerosol Effects on Stratiform and Shallow Convective MPCs
Stratiform MPCs are prevalent in the Arctic [67, 89] and in orographic terrain [28, 50, 57]. In situ observations and surface remote sensing suggest that clouds in the mixed-phase temperature range in mid-latitudes tend to consist almost entirely of ice or of liquid water [10, 11, 48]. This agrees with satellite observations over the Southern Ocean and North Pacific, which have shown that the most common cloud types are clouds with supercooled droplets at their tops [6, 65]. Glaciated cloud tops at temperatures warmer than −20∘C are rare. A large portion of cloud tops remains ambiguous from the MODIS satellite, which means they could be MPCs or have signals from multiple cloud layers . On a global scale, the fraction of supercooled water in MPCs at various temperatures from the ECHAM6 and different versions of the CAM GCM has been compared to CALIOP satellite estimates. None of the models captured the observed variation in the supercooled fraction with temperature correctly but either simulated too small or too high values at all temperatures . This is partly related to differences in INP concentrations and partly to differences in the involved parameterized microphysical processes.
Increasing the supercooled liquid water in shallow convective clouds substantially reduced the bias in the absorbed shortwave radiation in the present-day climate over the Southern Ocean in the CAM5 GCM . An error in the fraction of supercooled liquid water in stratiform MPCs in the present-day climate also has consequences for projections of global mean temperature at the time of CO 2 doubling . If ice in MPCs is overestimated in the present-day climate, a larger portion of that will be found in the liquid phase in a warmer climate. This overestimates the negative cloud phase feedback that partly offsets global warming. If the bias of the amount of ice in MPCs is reduced, the cloud phase feedback will be smaller and the temperature at the time of CO 2 doubling will be higher .
On a regional scale, low-level MPCs were studied extensively in the Arctic, where they occur frequently and are persistent [67, 78, 89, 103]. MPCs may be stabilized due to anthropogenic activity due to the deactivation effect  such that the sulfate-induced inhibition of freezing leads to fewer and larger ice crystals both in MPCs and pure ice clouds . Aerosol effects on Arctic MPCs have received lots of attention because MPCs play a central role in Arctic climate change and sea ice loss . The effect of anthropogenic aerosols on Arctic MPCs is not limited to the reflection of shortwave radiation, but also affects the longwave radiation by increasing the longwave emissivity [2, 22, 59].
Also cloud-resolving model simulations of Arctic clouds showed smaller albedo increases in MPCs than in warm clouds . Observations during the Indirect and Semi-Direct Aerosol Campaign (ISDAC) campaign in April 2008 were used to test various aerosol indirect effects in MPCs by correlating different cloud properties to the total accumulation mode aerosol concentration above and below cloud . There were indications that in some instances, mixing of aerosol particles into the cloud from above caused a glaciation indirect effect. Other cases suggested that secondary ice crystal production becomes less efficient because the number of cloud droplets large enough to cause splintering decreases with increasing aerosol load. The riming indirect effect (see below) did not seem to play a major role .
Little research has so far been conducted on possible aerosol effects on MPCs in the storm tracks of both hemispheres. Of the few studies that exist in the North Pacific, where these effects should be strongest due to the high anthropogenic emissions in East Asia, the results remain inconclusive as to whether or not anthropogenic aerosols noticeably increase precipitation from extratropical cyclones [39, 99, 105].
Aerosol Effects on Orographic MPCs
Orographic clouds and precipitation can be particularly prone to strong aerosol-cloud-precipitation interactions [38, 70, 80, 106] because the time for precipitation development is limited to the ascending branch of mountain flow. At the same time, the time for precipitation formation is constrained by the strong dynamical forcing of the orography.
Observations taken on top of Jungfraujoch in the Swiss Alps show persistent MPCs in those cases in which the updraft velocities are high enough to exceed saturation with respect to liquid water. This allows simultaneous growth of supercooled liquid droplets and ice crystals . However, as the ICNC exceeds the concentration of INP by orders of magnitude, no influence of anthropogenic aerosols on the persistence of MPCs could be deduced.
Decreasing snowfall rates with increasing anthropogenic aerosol loads have been observed in the Rocky Mountains through correlations of the snowfall rate with sulfate concentrations  and by comparing two case studies with a similar liquid water content . The authors suggested that this anticorrelation is caused by a reduction in the collision efficiency of snowflakes with smaller cloud droplets, which reduced the riming rate, and referred to it as a riming indirect effect. As riming leads to efficient precipitation formation in MPCs, a retardation of riming prolongs the development of precipitation and can cause some precipitation to spill over to the leeward side of the mountain [84, 106]. In a comparison of different numerical models, neither a decrease in riming was a robust result nor did an increase in aerosols necessarily lead to a reduction in precipitation . Given the large scatter in the data , the model findings do not necessarily contradict the measurements. This is because the effect of anthropogenic aerosols on cloud microphysics and orographic precipitation not only depends on the temperature of the MPCs and the concentrations of CCN and INP, but also on the synoptic situation and cloud dynamics and how these processes are described and interact with each other in numerical models [18, 20, 60, 69, 70].
In GCM simulations, the riming indirect effect was found to be of minor importance . Instead, the increased cloud optical depth due to pollution aerosols reduced the solar radiation and hence the temperature at the Earth surface and within the atmosphere. This in turn led to more ice in the atmosphere and hence more snowfall.
Aerosol Effects on Deep Convective Clouds
Freezing releases latent heat aloft and invigorates these cloud systems , but also in the lower levels of the cloud more latent heat is released by enhanced condensational growth [88, 93]. This is partly counteracted by the reduced buoyancy due to increased water loading. Ice crystals forming in upper levels grow into precipitation-sized particles that fall against the updraft. At temperatures above 0∘C, they melt and consume latent heat. For the same amount of surface precipitation, the polluted cloud has a larger upward heat transport because more precipitation originates via the ice phase. The larger heat transport results in an invigoration of the convective clouds with overall more precipitation, despite the slower conversion of cloud droplets to raindrops. The more numerous but smaller ice crystals in polluted clouds that sediment slower were found to increase the cloud cover of the stratiform anvil in the mature and dissipating stages of deep convective clouds . This may lead to an increased reflection of shortwave radiation as shown in Fig. 3.
Model simulations using a cloud system-resolving model show that either a weakened or an enhanced response of the surface precipitation rate of an idealized supercell storm to polluted conditions (realized by increasing the cloud droplet number concentration from 50 to 750 cm−3) can be found . If the polluted supercell storm produces more or less surface precipitation depends on how the cold pool strength changes in response to pollution, which in turn depends on how the cloud microphysical and thermodynamic processes are modified in different simulation set-ups. The cold pool strength is larger in those simulations that produce a larger convective mass flux and more surface precipitation. Differences in the response of deep convection to aerosol perturbations simulated by increasing the cloud droplet number concentration from 100 to 2500 cm−3 using two different state-of-the art cloud microphysical schemes within the WRF high-resolution model point to the importance of the treatment of snow and graupel (being one-moment in one scheme and two-moment in the other). The opposite responses in liquid water and ice mass of the polluted deep convective cloud compared to the clean cloud using these schemes show deficiencies in our understanding of convective processes and our ability to parameterize them well .
Aerosol Radiative Forcing Due to Aerosol-Cloud and Aerosol-Radiation Interactions
In IPCC AR5, GCM estimates of ERFaci + ari have been stratified into those that only include aerosol effects on warm stratiform clouds and those that went beyond that. In the category that included also aerosol effects on MPCs, the estimates ranged between −0.3 and −2 W m−2 . Part of this range can be explained by differences in the importance of the glaciation vs. the deactivation effect (see section Microphysical Processes and Aerosol Effects in MPCs) in different GCM simulations. Six studies considering aerosol effects on MPCs have been published since IPCC AR5, with best estimates of ERFaci + ari between −0.9 and −2.5 W m−2, i.e., covering a similar range but with more negative values than prior to AR5. Thus, the overall range of ERFaci + ari has increased.
A study conducted with CAM3 + coupled to the IMPACT aerosol module obtained an even more negative ERFaci + ari of −2.8 W m−2 (compared to −2.5 W m−2) in case that marine organics do not serve as INP . Such a reduction of ERFaci + ari caused by additional INP is consistent with the glaciation indirect effect discussed above.
In simulations with the ECHAM6 GCM coupled to the HAM2 aerosol scheme that include aerosol effects on stratiform warm and MPCs, the sensitivity of ERFaci + ari to aerosol processing, i.e., how important it is to account for the number of aerosol particles that are incorporated into cloud droplets and ice crystals during activation, nucleation, scavenging, and collisions, was investigated . Aerosol processing reduced ERFaci + ari by 0.1 to 0.4 W m−2 to −1.1 respectively −0.9 W m−2 depending on the stability function used in the turbulence scheme. Using ECHAM5-HAM2, it was shown that treating subgrid scale variability by introducing stochastic subcolumns in the calculations of cloud droplet activation and autoconversion (collision-coalescence of cloud droplets to form raindrops) reduced ERFaci + ari by 0.3 W m−2 to −1.3 W m−2 .
List of ERFaci + ari estimates [W m−2] shown in Fig. 5 divided into best estimate (best), range, changes in the SW and LW TOA radiation budget, and the category in which the estimate falls (with MPCs or with convective clouds (conv.)), if they were used in AR5 (yes/no) or are post-AR5 (post) estimates and the respective reference
Lohmann 2004 
−0.97 to −1.24
Jacobson 2006 
Lohmann & Diehl 2006 
−1.02 to −2.08
Storelvmo et al. 2008 
−0.07 to −0.27
Hoose et al. 2008 
−1.80 to −2.08
Lohmann & Hoose 2009 
−0.62 to −1.12
Hoose et al. 2010 
−1.55 to −1.89
Lohmann & Ferrachat 2010 
−0.87 to −1.12
Salzmann et al. 2010 
Storelvmo et al. 2010 
Yun & Penner 2013 
−2.52 to −2.82
Neubauer et al. 2014 
−0.90 to −2.30
Gettelman 2015 
−0.70 to −1.61
Gettelman et al. 2015 
−0.82 to −1.23
Sant et al. 2015 
−1.30 to −1.60
Tonttila et al. 2015 
−1.28 to −1.59
Menon & Rotstayn 2006 
Menon & Rotstayn 2006 
Menon & DelGenio 2007 
Lohmann 2008 
Unger et al. 2009 
Koch et al. 2009 
Wang et al. 2011 
Gettelman et al. 2015 
Because of the long timesteps in GCMs, most microphysics scheme only treat cloud water and ice as prognostic variables and diagnose the amount of precipitation every timestep. Recently, some climate modeling groups started to treat precipitation prognostically [24, 74, 86]. Because fast falling raindrops can violate the Courant-Friedrichs-Lewy criteria, GCMs with prognostic precipitation use sub-time stepping at least for sedimentation. The effect of sub-stepping cloud micro- and macrophysics (cloud fraction and condensation/deposition) on ERFaci + ari was investigated with CAM5.3 . It was found that ERFaci + ari is more sensitive to sub-stepping cloud macrophysics than cloud microphysics and that prognostic precipitation lowers ERFaci + ari by 2–33 % as compared to diagnostic precipitation. On the contrary, prognostic precipitation in ECHAM5-HAM increases ERFaci+ari by 0.3 W m−2, despite a 25 % reduction in the increase in liquid water path in response to anthropogenic aerosols . However, the difference in ERFaci + ari between prognostic and diagnostic precipitation in ECHAM5-HAM is within the interannual variability.
An analysis of the CMIP5 models showed that the decrease in the TOA SW radiation is much higher in those two models that consider aerosol effects on MPCs (−1.9 W m−2) than in the four models that only consider aerosol effects on warm clouds (−1.2 W m−2) . However, the CMIP5 models often use simpler aerosol schemes in order to save CPU time than the atmosphere-only GCMs discussed above. ERFaci+ari from the atmosphere-only GCMs shown in Fig. 5 simulate an average decrease in the TOA SW radiation of only −1.4 W m−2 possible due to their more sophisticated aerosol schemes. In the two CMIP5 models that consider aerosol effects on MPCs, the longwave (LW) radiation is reduced by 0.7 W m−2 , which again is much larger than the averaged change in outgoing LW radiation of 0.15 W m−2 from the atmosphere-only GCMs shown in Fig. 5. Note, however, that changes in the LW radiation range from −0.3 to + 0.5 W m−2, i.e., the clouds become either more or less transparent to LW radiation in response to anthropogenic aerosols or experience a decrease or increase in cloud height, respectively.
Until now, the horizontal resolution in GCMs is too coarse to resolve deep convective clouds and hence, they need to be parameterized. Because of that, global estimates of aerosol effects on stratiform and convective clouds are rather uncertain and range between −0.4 and −3.4 W m−2 with an average of −1.7 W m−2 (green diamonds in Fig. 5), which is −0.5 W m−2 more negative than aerosol effects on stratiform warm and MPCs.
Of the eight estimates that include aerosol effects on stratiform and convective clouds, only four provided a breakdown into the changes in SW and LW TOA radiation. These four studies include the three estimates that were used in AR5 plus one new study . Their averaged ERFaci+ari of −1.3 W m−2 is rather comparable to the ERFaci+ari of stratiform warm and MPCs. The averaged SW effect from these four studies is −1.5 W m−2, which again is only slightly more negative than the SW effect of aerosols on stratiform warm and MPCs. The averaged LW effect from these studies of 0.15 W m−2 is as large as for aerosol effects on stratiform warm and MPCs.
While in the ECHAM5-HAM GCM evidence for convective invigoration when including aerosol effects on convective clouds was found , this did not significantly change ERFaci+ari as compared to a simulation in which aerosol effects on convective clouds were ignored, i.e., the reflection of SW radiation from anvils of polluted clouds as shown in Fig. 3 is negligible.
In a multi-scale modeling framework, where the relevant cloud-scale circulations are resolved, ERFaci+ari is reduced by 40% from −1.8 W m−2 down to −1.05 W m−2  yielding one of the lowest ERFaci+ari estimates in that category (Fig. 5). In this framework, the liquid water path increases much less in response to anthropogenic aerosols because more buffering mechanisms, such as enhanced evaporation of the smaller polluted cloud droplets, can take place. Because a multi-scale modeling framework is computationally very expensive, other pathways that improve convection in GCMs need to be pursued as well. One promising approach is the spectral convective parameterization representing the statistical effects of a heterogeneous ensemble of cumulus clouds  extended with an explicit cloud model based on a one-dimensional steady-state entraining plume .
Mixed-phase clouds remain one of the least studied cloud types because they are not as easy to access as warm clouds and require instrumentation that distinguishes cloud droplets from ice crystals. However, they are persistent at least in the Arctic and in orographic terrain. If they are incorrectly simulated in the present-day climate in global climate models, that can also affect the global mean warming in a 2 ×CO2 climate because of the negative cloud phase feedback .
Since the publication of the IPCC AR5 report , six new global estimates of ERFaci + ari considering aerosol effects on stratiform warm and MPCs are available from atmosphere-only GCMs, ranging between −0.9 and −2.5 W m−2. With that, the average ERFaci + ari on stratiform warm and MPCs is −1.2 W m−2, where the contribution of the changes in LW radiation is rather minor with + 0.15 W m−2. This is in line with the recent estimate from re-analyzing the CMIP5 GCMs , but is more negative than estimated in IPCC AR5  and as obtained from a simple model .
There are only half as many estimates of aerosol effects on stratiform and convective clouds and they are more variable and uncertain. The average ERFaci + ari from those models that provide a breakdown in SW and LW radiation changes of −1.3 W m−2 is comparable to ERFaci + ari considering aerosol effects on stratiform warm and MPCs. Differences between various ERFaci + ari estimates are caused by different parameterization schemes for cloud microphysics and other processes, different aerosol schemes, different base years for pre-industrial emissions (1750 vs. 1850), and different model resolutions. These uncertainties need to be reduced and the estimates of ERFaci + ari from bottom-up estimates need to be reconciled with observations of the temperature record since pre-industrial times to increase our confidence in the anthropogenic aerosol forcing.
I would like to acknowledge Trude Storelvmo and Zamin Kanji for fruitful discussions, Sylvaine Ferrachat and Fabian Mahrt for help with the figures, and Joel Knain for providing a photograph of a hole punch cloud. The research leading to these results has received partly funding from the European Union’s Seventh Framework Programme (FP7/2007-2013) project BACCHUS under grant agreement no. 603445.
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Conflict of Interests
There is no conflict of interest.
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