Allergo Journal International

, Volume 24, Issue 2, pp 58–66 | Cite as

Hypersensitivity reactions to modern antiplatelet and anticoagulant drugs

  • Kathrin Scherer Hofmeier
  • Andreas J. Bircher


Anticoagulation and antiplatelet drugs are among the most commonly used medical drugs. In addition to the long-established heparins, hirudins, coumarins and antiplatelet drugs such as acetylsalicylic acid, numerous novel and predominantly synthetic pharmacologic agents have come onto the market in recent years. These new agents act at various sites in coagulation and have significantly broadened treatment options. Whilst immunological hypersensitivity reactions are on the whole rare, they have a considerable impact on patient management when they do occur. The present overview discusses the currently known hypersensitivity reactions to anticoagulant and antiplatelet agents, with particular attention to the newer substance classes including P2Y12 inhibitors, glycoprotein IIb/IIIb receptor antagonists, direct factor Xa inhibitors and direct thrombin inhibitors.


thienopyridine GP IIb/IIIa receptor antagonists factor Xa inhibitor direkt thrombin inhibitors hyper sensitivity 



Arachidonic acid


Adenosine diphosphate


Adverse drug reaction


Aspirin exacerbated respiratory disease


Acute generalized exanthematous pustulosis


Acetylsalicylic acid


Cyclic adenosine monophosphate


Carboxyl group


Cytochrome P450


Drug induced liver injury


Drug rash with eosinophilia and systemic systems


European Medicines Agency


Fragment antigen binding


US Food and Drug Administration




Human antichimeric antibodies


Human anti-murine antibodies


Heparin-induced thrombocytopenia


Human leukocyte antigen


High molecular weight heparin (unfractionated heparin)




Low molecular weight heparin




Nonsteroidal anti-inflammatory drugs






Adenosine receptor


Severe cutaneous adverse reaction


Toxic epidermal necrolysis


Transient ischemic attack


Thromboxane receptor


Thromboxane A2


World Health Organization


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Copyright information

© Urban & Vogel 2015

Authors and Affiliations

  • Kathrin Scherer Hofmeier
    • 1
    • 2
  • Andreas J. Bircher
    • 1
  1. 1.Allergy Unit, Department of DermatologyUniversity HospitalBaselSwitzerland
  2. 2.Allergy Unit Department of DermatologyUniversity Hospital BaselBaselSwitzerland

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