Allergo Journal International

, Volume 23, Issue 3, pp 96–112 | Cite as

Guideline for acute therapy and management of anaphylaxis

S2 Guideline of the German Society for Allergology and Clinical Immunology (DGAKI), the Association of German Allergologists (AeDA), the Society of Pediatric Allergy and Environmental Medicine (GPA), the German Academy of Allergology and Environmental Medicine (DAAU), the German Professional Association of Pediatricians (BVKJ), the Austrian Society for Allergology and Immunology (ÖGAI), the Swiss Society for Allergy and Immunology (SGAI), the German Society of Anaesthesiology and Intensive Care Medicine (DGAI), the German Society of Pharmacology (DGP), the German Society for Psychosomatic Medicine (DGPM), the German Working Group of Anaphylaxis Training and Education (AGATE) and the patient organization German Allergy and Asthma Association (DAAB)
  • Johannes RingEmail author
  • Kirsten Beyer
  • Tilo Biedermann
  • Andreas Bircher
  • Dorothea Duda
  • Jörg Fischer
  • Frank Friedrichs
  • Thomas Fuchs
  • Uwe Gieler
  • Thilo Jakob
  • Ludger Klimek
  • Lars Lange
  • Hans F. Merk
  • Bodo Niggemann
  • Oliver Pfaar
  • Bernhard Przybilla
  • Franziska Ruëff
  • Ernst Rietschel
  • Sabine Schnadt
  • Roland Seifert
  • Helmut Sitter
  • Eva-Maria Varga
  • Margitta Worm
  • Knut Brockow


Anaphylaxis is an acute systemic reaction with symptoms of an immediate-type allergic reaction which can involve the whole organism and is potentially life-threatening [1, 2, 3].

The definition of anaphylaxis is not globally uniform. At present different classification systems are used. In German-speaking countries, the classification used here has generally been applied until now.

Anaphylactic reactions are the most severe and potentially life-threatening dramatic conditions seen in allergy. Acute treatment is based on international guidelines and recommendations in textbooks. In 1994, a position paper of the German Society for Allergology and Clinical Immunology (DGAKI), was published in the Allergo Journal as the result of an interdisciplinary consensus conference [4]. This was subsequently updated and published as a guideline in 2007 [5].

On resolution of the board of directors of the DGAKI of 2009, the anaphylaxis working group was asked to update the guideline. The...


Anaphylactic Reaction Omalizumab Mastocytosis Laryngeal Tube Acute Urticaria 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



Angiotensin-converting enzyme


Fraction of inspired oxygen


Hydroxyethyl starch


odium chloride


Nonsteroidal anti inflammatory drugs


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Copyright information

© Urban & Vogel 2014

Authors and Affiliations

  • Johannes Ring
    • 1
    Email author
  • Kirsten Beyer
    • 2
  • Tilo Biedermann
    • 3
  • Andreas Bircher
    • 4
  • Dorothea Duda
    • 5
  • Jörg Fischer
    • 3
  • Frank Friedrichs
    • 6
  • Thomas Fuchs
    • 7
  • Uwe Gieler
    • 8
  • Thilo Jakob
    • 9
  • Ludger Klimek
    • 10
  • Lars Lange
    • 11
  • Hans F. Merk
    • 12
  • Bodo Niggemann
    • 13
  • Oliver Pfaar
    • 10
  • Bernhard Przybilla
    • 14
  • Franziska Ruëff
    • 14
  • Ernst Rietschel
    • 15
  • Sabine Schnadt
    • 16
  • Roland Seifert
    • 17
  • Helmut Sitter
    • 18
  • Eva-Maria Varga
    • 19
  • Margitta Worm
    • 20
  • Knut Brockow
    • 1
  1. 1.Dept. Dermatology and Allergology Biederstein, Christine Kuehne-Center Allergy Research and Education (CK-CARE)Technical University MunichMunichGermany
  2. 2.Department of Pediatrics, Division of Pneumonology and ImmunologyCharité University Medical CentreBerlinGermany
  3. 3.University Department of DermatologyTübingenGermany
  4. 4.Department of DermatologyUniversity Hospital of BaselBaselSwitzerland
  5. 5.Department of Anesthesiology and Critical Care MedicineUniversity MainzMainzGermany
  6. 6.Pediatric practice LaurensbergAachenGermany
  7. 7.Department of DermatologyUniversity Hospital GöttingenGöttingenGermany
  8. 8.Dept. of Psychosomatic Medicine and PsychotherapyUniversity of GießenGießenGermany
  9. 9.Department of Dermatology of the University Medical CenterFreiburgGermany
  10. 10.Center for Rhinology and Allergology Wiesbaden, ENT Dept. University of MannheimMannheimGermany
  11. 11.St.-Marien-Hospital BonnBonnGermany
  12. 12.Department of DermatologyUniversity AachenAachenGermany
  13. 13.DRK Kliniken Berlin WestendBerlinGermany
  14. 14.Department of Dermatology and AllergologyHospital of the Ludwig Maximilians UniversityMunichDeutschland
  15. 15.Department of PediatricsUniversity Hospital CologneCologneGermany
  16. 16.German Allergy and Asthma AssociationMönchengladbachGermany
  17. 17.Institute of Pharmacology, Hannover Medical SchoolHannoverGermany
  18. 18.Institute for Surgical Research, Philipps University of MarburgBerlinGermany
  19. 19.Department of PediatricsMedical University of GrazGrazAustria
  20. 20.Department of Dermatology Venereology and Allergology, Allergie-Centrum-CharitéCharité University Medical CentreBerlinGermany

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