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Journal of Nephrology

, Volume 32, Issue 1, pp 75–81 | Cite as

Effects of fenoldopam on renal blood flow in hypertensive chronic kidney disease

  • Valentina Rovella
  • Michele Ferrannini
  • Manfredi Tesauro
  • Giulia Marrone
  • Andrea Busca
  • Roberto Sorge
  • Simone Manca di Villahermosa
  • Maurizio Casasco
  • Nicola Di DanieleEmail author
  • Annalisa NoceEmail author
Original Article
  • 49 Downloads

Abstract

Background and aim

The synthetic drug fenoldopam mesylate (FM) may have a renoprotective role, and a “renal dose” of 0.1 µg/kg/min intravenous (IV) infusion of FM has been reported as able to increase renal blood flow without affecting systemic blood pressure. But conclusive data are still lacking. We aimed to investigate by color-Doppler ultrasonography the effects of IV administration of FM at this dosage in hypertensive chronic kidney disease (CKD) patients, and verify whether it may induce any systemic hemodynamic alteration.

Methods

In 60 hypertensive CKD patients, we measured by duplex Doppler ultrasonography, at baseline and during infusion of 0.1 µg/kg/min of FM, the systolic and diastolic flow velocity (sampled at the renal hilum, intermediate section and origin of both renal arteries) and the intra-parenchymal renal resistive index (RRI) sampled on interlobular arteries of both kidneys. Patients were divided into four subgroups (I–IV) according to classification of National Kidney Foundation Kidney Disease Outcomes Quality Initiative (NKF-DOQI).

Results

Infusion of 0.1 µg/kg/min FM significantly decreased the RRI (0.73 ± 0.05 vs. 0.65 ± 0.06; p < 0.0001) and increased the systolic and diastolic flow velocities in all renal artery tracts examined. No single episode of systemic hypotension was observed.

Conclusions

Very low-dose FM may significantly increase renal blood flow and exert a renal protective effect in hypertensive CKD patients. Infusion of FM at such low dosage appears also to be quite safe, even in CKD and hypertensive patients.

Keywords

Fenoldopam mesylate Chronic kidney disease Renal resistive index Arterial hypertension Renal blood flow 

Notes

Compliance with ethical standards

Conflict of interest

The authors declare no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. Number EudraCT: 2010-019523-63.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Copyright information

© Italian Society of Nephrology 2018

Authors and Affiliations

  • Valentina Rovella
    • 1
  • Michele Ferrannini
    • 1
  • Manfredi Tesauro
    • 1
  • Giulia Marrone
    • 1
    • 2
  • Andrea Busca
    • 1
  • Roberto Sorge
    • 3
  • Simone Manca di Villahermosa
    • 1
  • Maurizio Casasco
    • 4
  • Nicola Di Daniele
    • 1
    Email author
  • Annalisa Noce
    • 1
    Email author
  1. 1.Division of Hypertension and Nephrology, Department of Systems MedicineUniversity of Rome “Tor Vergata”RomeItaly
  2. 2.PhD School of Applied Medical-Surgical SciencesUniversity of Rome “Tor Vergata”RomeItaly
  3. 3.Laboratory of Biometry, Department of Systems MedicineUniversity of Rome “Tor Vergata”RomeItaly
  4. 4.Federazione Medico Sportiva ItalianaRomeItaly

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