Journal of Nephrology

, Volume 31, Issue 1, pp 1–13 | Cite as

Recommendations for the treatment of hepatitis C virus infection in chronic kidney disease: a position statement by the Spanish association of the liver and the kidney

  • Sami Aoufi-Rabih
  • Rebeca García-AgudoEmail author
  • María-Carlota Londoño
  • María-Dolores Fraga-Fuentes
  • Guillermina Barril-Cuadrado
  • On behalf on the Spanish Association of the Liver and the Kidney (AEHR)
Position Papers and Guidelines


Hepatitis C virus (HCV) infection is one of the main causes of liver cirrhosis worldwide. The long-term impact of HCV infection is highly variable, ranging from minimal histological changes to extensive fibrosis with hepatocellular carcinoma. The development of HCV drugs has increased dramatically in recent years, even in special populations such as chronic kidney disease patients. Classical treatment of chronic hepatitis C was based on the administration of interferon and ribavirin for 24–48 weeks, which was associated with a poor viral response and a high rate of side effects, especially in patients with a lower estimated glomerular filtration rate. The current high availability of the new direct-acting antivirals renders the classification of these agents for this special population necessary. The Spanish Association of the Liver and the Kidney has produced a position statement on the treatment of HCV infection in chronic kidney disease patients since the evidence to guide this treatment is scant and what evidence does exist is weak. The recommendations are based on the results of clinical trials and controlled studies conducted to date, with data published hitherto by the authors of these studies. Since the indications for treatment have been evaluated by other societies or are dependent on internal clinical protocols, the main goal of this position statement is to assist in decision-making when choosing a therapeutic option.


Hepatitis C virus Chronic kidney disease Cirrhosis Direct-acting antiviral 



Beatriz Proy Vega contributed to the investigation of this work.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Research involving human participants or animals

This article does not contain any studies with human participants or animals performed by any of the authors.

Informed consent

For this type of study formal consent is not required.


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Copyright information

© Italian Society of Nephrology 2017

Authors and Affiliations

  • Sami Aoufi-Rabih
    • 1
  • Rebeca García-Agudo
    • 2
    Email author
  • María-Carlota Londoño
    • 3
  • María-Dolores Fraga-Fuentes
    • 4
  • Guillermina Barril-Cuadrado
    • 5
  • On behalf on the Spanish Association of the Liver and the Kidney (AEHR)
  1. 1.Hepatorenal Unit, Department of Gastroenterology and HepatologyHospital General La Mancha-CentroAlcázar de San JuanSpain
  2. 2.Hepatorenal Unit, Department of NephrologyHospital General La Mancha-CentroAlcázar de San JuanSpain
  3. 3.Hepatology UnitHospital ClínicBarcelonaSpain
  4. 4.Department of PharmacyHospital General La Mancha-CentroAlcázar de San JuanSpain
  5. 5.Department of NephrologyHospital Universitario La PrincesaMadridSpain

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